Formulations pour le traitement local de tumeurs solides par hyperthermie à médiation magnétique

Abstract : In this work, we review the advances to obtain pharmaceutical formulations relevant for the recent magnetically mediated modality of hyperthermia treatment of cancer lesions, mainly solid tumors. We introduce in the first part biological rationales with respect to the technical means presently implemented in clinics for hyperthermia treatment, focusing on magnetically mediated modalities. We will then discuss the potential of the pharmaceutical formulation gathered. In the second part, we will consider biomaterials based on ceramics, glasses and cements that are indicated in the hyperthermia treatment of solid bone tumors by magnetically mediated modality, taking pathophysiological particularities in account. In the third part, we will present the formulations for the hyperthermic treatment of solid tumors of soft tissue by magnetically induced modalities, insisting on pharmacological and biochemical modulations. The fourth and last part is dedicated to liposomes formulations, centrally on magneto-liposomes that can be administrated in various tumor in view of magnetically mediated hyperthermia. We cannot detail here the magnetic fluid formulations, consisting in suspension of coated magnetic nanoparticles. The important biological and immunological considerations will be thoroughly considered. This review will emphasize the extremely complex but central interactions in link with hyperthermia that should be considered for clinical application.
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https://tel.archives-ouvertes.fr/tel-00580668
Contributor : Pol-Edern Le Renard <>
Submitted on : Monday, March 28, 2011 - 10:56:59 PM
Last modification on : Monday, April 16, 2018 - 10:41:48 AM
Document(s) archivé(s) le : Wednesday, June 29, 2011 - 3:01:43 AM

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Pol-Edern Le Renard. Formulations pour le traitement local de tumeurs solides par hyperthermie à médiation magnétique. Médicaments. Université de Nancy, 2011. Français. ⟨tel-00580668⟩

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