Skip to Main content Skip to Navigation
Journal articles

Incidence and severity of pertussis hospitalisations in infants aged less than 1 year in 37 hospitals of six EU/EEA countries, results of PERTINENT sentinel pilot surveillance system, December 2015 to December 2018

Lore Merdrignac 1, * Fatima Aït El Belghiti 2 Elisabetta Pandolfi 3 Mireia Jané 4 Jane Murphy 5 Kateřina Fabiánová 6 Manuel García Cenoz 7 Elmira Flem 8 Sophie Guillot 9 Alberto Tozzi 3 Gloria Carmona 4 Adele Habington 10 Jana Zavadilová 6 Ana Navasués 11 Håkon Bøås 8 Daniel Lévy-Brühl 2 Beatrice Ferretti 3 Miguel Lanaspa 12 Niam O'Sullivan 10 Pavla Křížová 6 Leticia Fernandino 7 Terese Bekkevold 8 Thomas Hanslik 13 Carmen Muñoz-Almagro 12, 14, 15 Sabrina Bacci 16 Gianfranco Spiteri 16 Marta Valenciano 1 Alain Moren 1
Abstract : Introduction PERTINENT is a pilot active surveillance system of infants hospitalised with pertussis in six European Union/European Economic Area countries (37 hospitals, seven sites). Aim This observational study aimed to estimate annual pertussis incidence per site from 2016 to 2018 and respective trends between 2017 and 2018. Pertussis cases were described, including their severity. Methods We developed a generic protocol and laboratory guidelines to harmonise practices across sites. Cases were hospitalised infants testing positive for Bordetella pertussis by PCR or culture. Sites collected demographic, clinical, laboratory data, vaccination status, and risk/protective factors. We estimated sites' annual incidences by dividing case numbers by the catchment populations. Results From December 2015 to December 2018, we identified 469 cases (247 males; 53%). The median age, birthweight and gestational age were 2.5 months (range: 0-11.6; interquartile range (IQR): 2.5), 3,280 g (range: 700-4,925; IQR: 720) and 39 weeks (range: 25-42; IQR: 2), respectively. Thirty cases (6%) had atypical presentation either with cough or cyanosis only or with absence of pertussis-like symptoms. Of 330 cases with information, 83 (25%) were admitted to intensive care units including five deceased infants too young to be vaccinated. Incidence rate ratios between 2018 and 2017 were 1.43 in Czech Republic (p = 0.468), 0.25 in Catalonia (p = 0.002), 0.71 in France (p = 0.034), 0.14 in Ireland (p = 0.002), 0.63 in Italy (p = 0.053), 0.21 in Navarra (p = 0.148) and zero in Norway. Conclusions Incidence appeared to decrease between 2017 and 2018 in all but one site. Enhanced surveillance of hospitalised pertussis in Europe is essential to monitor pertussis epidemiology and disease burden.
Document type :
Journal articles
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-03197871
Contributor : Sylvain Brisse <>
Submitted on : Wednesday, April 14, 2021 - 11:52:52 AM
Last modification on : Friday, August 6, 2021 - 11:26:02 AM
Long-term archiving on: : Thursday, July 15, 2021 - 6:22:37 PM

File

_Merdrignac_eurosurv-26-4-1.pd...
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Lore Merdrignac, Fatima Aït El Belghiti, Elisabetta Pandolfi, Mireia Jané, Jane Murphy, et al.. Incidence and severity of pertussis hospitalisations in infants aged less than 1 year in 37 hospitals of six EU/EEA countries, results of PERTINENT sentinel pilot surveillance system, December 2015 to December 2018. Eurosurveillance, European Centre for Disease Prevention and Control, 2021, 26 (4), pp.1900762. ⟨10.2807/1560-7917.ES.2021.26.4.1900762⟩. ⟨pasteur-03197871⟩

Share

Metrics

Record views

83

Files downloads

175