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Selenoprotein Gene Nomenclature

Vadim N. Gladyshev 1, 2, * Elias S. Arnér 3 Marla J. Berry 4 Regina Brigelius-Flohé 5 Elspeth A. Bruford 6 Raymond F. Burk 7 Bradley A. Carlson 8 Sergi Castellano 9 Laurent Chavatte 10 Marcus Conrad 11 Paul R. Copeland 12 Alan M. Diamond 13 Donna M. Driscoll 14 Ana Ferreiro 15, 16 Leopold Flohé 17, 18 Fiona R. Green 19 Roderic Guigó 20 Diane E. Handy 1 Dolph L. Hatfield 8 John Hesketh 21 Peter R. Hoffmann 4 Arne Holmgren 3 Robert J. Hondal 22 Michael T. Howard 23 Kaixun Huang 24 Hwa-young Kim 25 Ick young Kim 26 Josef Köhrle 27 Alain Krol 28 Gregory V. Kryukov 29 Byeong Jae Lee 30 Byung Cheon Lee 26 Xin Gen Lei 31 Qiong Liu 32 Alain Lescure 28 Alexei V. Lobanov 1 Joseph Loscalzo 1 Matilde Maiorino 18 Marco Mariotti 1 K. Sandeep Prabhu 33 Margaret P. Rayman 34 Sharon Rozovsky 35 Gustavo Salinas 36 Edward E. Schmidt 37 Lutz Schomburg 27 Ulrich Schweizer 38 Miljan Simonović 13 Roger A. Sunde 39 Petra A. Tsuji 40 Susan Tweedie 6 Fulvio Ursini 18 Philip D. Whanger 41 yan Zhang 32 
* Corresponding author
Abstract : The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein-encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP), SELENOT (selenoprotein T, SELT), SELENOV (selenoprotein V, SELV), and SELENOW (selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.
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Vadim N. Gladyshev, Elias S. Arnér, Marla J. Berry, Regina Brigelius-Flohé, Elspeth A. Bruford, et al.. Selenoprotein Gene Nomenclature. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (46), pp.24036 - 24040. ⟨10.1074/jbc.M116.756155⟩. ⟨pasteur-01882353⟩

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