The perivascular origin of pathological fibroblasts

Abstract : The ability to repair tissues is essential for the survival of organisms. In chronic settings, the failure of the repair process to terminate results in overproduction of collagen, a pathology known as fibrosis, which compromises organ recovery and impairs function. The origin of the collagen-overproducing cell has been debated for years. Here we review recent insights gained from the use of lineage tracing approaches in several organs. The resulting evidence points toward specific subsets of tissue-resident mesenchymal cells, mainly localized in a perivascular position, as the major source for collagen-producing cells after injury. We discuss these findings in view of the functional heterogeneity of mesenchymal cells of the perivascular niche, which have essential vascular, immune, and regenerative functions that need to be preserved for efficient repair.
Type de document :
Article dans une revue
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (1), pp.54 - 63. 〈10.1172/JCI93558〉
Liste complète des métadonnées

Littérature citée [120 références]  Voir  Masquer  Télécharger

https://hal-pasteur.archives-ouvertes.fr/pasteur-01708378
Contributeur : Carina Tomasso Deverge <>
Soumis le : mardi 13 février 2018 - 15:44:16
Dernière modification le : mercredi 14 février 2018 - 10:07:15

Fichier

JCI93558.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Selene Di Carlo, Lucie Peduto. The perivascular origin of pathological fibroblasts. Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (1), pp.54 - 63. 〈10.1172/JCI93558〉. 〈pasteur-01708378〉

Partager

Métriques

Consultations de la notice

48

Téléchargements de fichiers

11