R. Jambou, E. Legrand, M. Niang, N. Khim, P. Lim et al., Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6, The Lancet, vol.366, issue.9501, pp.3661960-1963, 2005.
DOI : 10.1016/S0140-6736(05)67787-2

URL : https://hal.archives-ouvertes.fr/pasteur-00590989

I. Zongo, G. Dorsey, N. Rouamba, H. Tinto, C. Dokomajilar et al., Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial, The Lancet, vol.369, issue.9560, pp.369491-498, 2007.
DOI : 10.1016/S0140-6736(07)60236-0

M. Meremikwu, A. Alaribe, R. Ejemot, A. Oyo-ita, J. Ekenjoku et al., Artemether-lumefantrine versus artesunate plus amodiaquine for treating uncomplicated childhood malaria in Nigeria: randomized controlled trial, Malaria Journal, vol.5, issue.1, p.43, 2006.
DOI : 10.1186/1475-2875-5-43

Z. Bozdech, M. Llinas, B. Pulliam, E. Wong, J. Zhu et al., The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum, PLoS Biology, vol.280, issue.1, p.5, 2003.
DOI : 10.1371/journal.pbio.0000005.st007

L. Roch, K. Zhou, Y. Blair, P. Grainger, M. Moch et al., Discovery of gene function by expression profiling of the malaria parasite life cycle, Science, issue.5639, pp.3011503-1508, 2003.

E. Dahl, J. Shock, B. Shenai, J. Gut, J. Derisi et al., Tetracyclines Specifically Target the Apicoplast of the Malaria Parasite Plasmodium falciparum, Antimicrobial Agents and Chemotherapy, vol.50, issue.9, pp.3124-3131, 2006.
DOI : 10.1128/AAC.00394-06

K. Deitsch, M. Duraisingh, R. Dzikowski, A. Gunasekera, S. Khan et al., Mechanisms of gene regulation in Plasmodium, Am J Trop Med Hyg, vol.77, issue.2, pp.201-208, 2007.

A. Gunasekera, A. Myrick, K. Roch, E. Winzeler, and D. Wirth, Plasmodium falciparum : Genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment WHO: Antimalarial drug combination therapy, WHO/CDS/ RBM Geneva, 2001.

R. Haynes and K. S. , Artemisinins: activities and actions, Microbes and Infection, vol.6, issue.14, pp.1339-1346, 2004.
DOI : 10.1016/j.micinf.2004.09.002

T. Hien, T. Davis, L. Chuong, K. Ilett, D. Sinh et al., Comparative pharmacokinetics of intramuscular artesunate and artemether in patients with severe falciparum malaria, Antimicrob Agents Chemother, issue.11, pp.484234-4239, 2004.

M. Oakley, S. Kumar, V. Anantharaman, H. Zheng, B. Mahajan et al., Molecular Factors and Biochemical Pathways Induced by Febrile Temperature in Intraerythrocytic Plasmodium falciparum Parasites, Infection and Immunity, vol.75, issue.4, pp.2012-2025, 2007.
DOI : 10.1128/IAI.01236-06

K. Lingelbach and J. Przyborski, The long and winding road: Protein trafficking mechanisms in the Plasmodium falciparum infected erythrocyte, Molecular and Biochemical Parasitology, vol.147, issue.1, pp.1-8, 2006.
DOI : 10.1016/j.molbiopara.2006.01.014

A. Bahl, B. Brunk, J. Crabtree, M. Fraunholz, B. Gajria et al., PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data, Nucleic Acids Research, vol.31, issue.1, pp.31212-215, 2003.
DOI : 10.1093/nar/gkg081

C. Hertz-fowler, C. Peacock, V. Wood, M. Aslett, A. Kerhornou et al., GeneDB: a resource for prokaryotic and eukaryotic organisms, Nucleic Acids Research, vol.32, issue.90001, pp.32-339, 2004.
DOI : 10.1093/nar/gkh007

H. Ginsburg, Malaria Parasite Metabolic Pathways

R. Coulson, N. Hall, and C. Ouzounis, Comparative Genomics of Transcriptional Control in the Human Malaria Parasite Plasmodium falciparum, Genome Research, vol.14, issue.8, pp.1548-1554, 2004.
DOI : 10.1101/gr.2218604

C. Doerig, Protein kinases as targets for anti-parasitic chemotherapy, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, vol.1697, issue.1-2, pp.155-168, 2004.
DOI : 10.1016/j.bbapap.2003.11.021

URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.5861

P. Acharya, R. Kumar, and U. Tatu, Chaperoning a cellular upheaval in malaria: Heat shock proteins in Plasmodium falciparum, Molecular and Biochemical Parasitology, vol.153, issue.2, pp.85-94, 2007.
DOI : 10.1016/j.molbiopara.2007.01.009

M. Botha, E. Pesce, and G. Blatch, The Hsp40 proteins of Plasmodium falciparum and other apicomplexa: Regulating chaperone power in the parasite and the host, The International Journal of Biochemistry & Cell Biology, vol.39, issue.10, pp.391781-1803, 2007.
DOI : 10.1016/j.biocel.2007.02.011

S. Pavithra, R. Kumar, and U. Tatu, Systems Analysis of Chaperone Networks in the Malarial Parasite Plasmodium falciparum, PLoS Computational Biology, vol.13, issue.9, pp.1701-1715, 2007.
DOI : 10.1371/journal.pcbi.0030168.sg004

K. Becker, L. Tilley, J. Vennerstrom, D. Roberts, S. Rogerson et al., Oxidative stress in malaria parasite-infected erythrocytes: host???parasite interactions, International Journal for Parasitology, vol.34, issue.2, pp.163-189, 2004.
DOI : 10.1016/j.ijpara.2003.09.011

Z. Bozdech and H. Ginsburg, Antioxidant defense in Plasmodium falciparum--data mining of the transcriptome, Malaria Journal, vol.3, issue.1, p.23, 2004.
DOI : 10.1186/1475-2875-3-23

R. Noiva, Protein disulfide isomerase: The multifunctional redox chaperone of the endoplasmic reticulum, Seminars in Cell & Developmental Biology, vol.10, issue.5, pp.481-493, 1999.
DOI : 10.1006/scdb.1999.0319

H. Sztajer, B. Gamain, K. Aumann, C. Slomianny, K. Becker et al., The Putative Glutathione Peroxidase Gene of Plasmodium falciparum Codes for a Thioredoxin Peroxidase, Journal of Biological Chemistry, vol.276, issue.10
DOI : 10.1074/jbc.M008631200

M. Reed, K. Saliba, S. Caruana, K. Kirk, and A. Cowman, Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum, Nature, issue.6772, pp.403906-909, 2000.

A. Sidhu, A. Uhlemann, S. Valderramos, J. Valderramos, S. Krishna et al., Malaria Heightens Susceptibility to Mefloquine, Lumefantrine, Halofantrine, Quinine, and Artemisinin, The Journal of Infectious Diseases, vol.194, issue.4, pp.528-535, 2006.
DOI : 10.1086/507115

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978021

P. Rohrbach, C. Sanchez, K. Hayton, O. Friedrich, J. Patel et al., Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum, The EMBO Journal, vol.3, issue.13, pp.253000-3011, 2006.
DOI : 10.1073/pnas.82.9.2784

R. Price, C. Cassar, A. Brockman, M. Duraisingh, M. Van-vugt et al., The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand, Antimicrob Agents Chemother, issue.12, pp.432943-2949, 1999.

R. Price, A. Uhlemann, A. Brockman, R. Mcgready, E. Ashley et al., Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number, The Lancet, vol.364, issue.9432, pp.364438-447, 2004.
DOI : 10.1016/S0140-6736(04)16767-6

M. Duraisingh and A. Cowman, Contribution of the pfmdr1 gene to antimalarial drug-resistance, Acta Tropica, vol.94, issue.3, pp.181-190, 2005.
DOI : 10.1016/j.actatropica.2005.04.008

J. Mazumdar and B. Striepen, Make It or Take It: Fatty Acid Metabolism of Apicomplexan Parasites, Eukaryotic Cell, vol.6, issue.10, pp.1727-1735, 2007.
DOI : 10.1128/EC.00255-07

L. Bethke, M. Zilversmit, K. Nielsen, J. Daily, S. Volkman et al., Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum, Molecular and Biochemical Parasitology, vol.150, issue.1, pp.10-24, 2006.
DOI : 10.1016/j.molbiopara.2006.06.004

M. Tellez, F. Matesanz, and A. Alcina, The C-terminal domain of the Plasmodium falciparum acyl-CoA synthetases PfACS1 and PfACS3 functions as ligand for ankyrin, Molecular and Biochemical Parasitology, vol.129, issue.2, pp.191-198, 2003.
DOI : 10.1016/S0166-6851(03)00123-3

K. Mullin, L. Lim, S. Ralph, T. Spurck, E. Handman et al., Membrane transporters in the relict plastid of malaria parasites, Proceedings of the National Academy of Sciences, vol.103, issue.25, pp.9572-9577, 2006.
DOI : 10.1073/pnas.0602293103

S. Ralph, G. Van-dooren, R. Waller, M. Crawford, M. Fraunholz et al., Metabolic maps and functions of the Plasmodium falciparum apicoplast, Nature Reviews Microbiology, vol.16, issue.3, pp.203-216, 2004.
DOI : 10.1093/nar/gkg081

H. Painter, J. Morrisey, M. Mather, and A. Vaidya, Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum, Nature, vol.6, issue.7131, pp.44688-91, 2007.
DOI : 10.1038/nature05572

J. Armstrong, The role of the mitochondrial permeability transition in cell death, Mitochondrion, vol.6, issue.5, pp.225-234, 2006.
DOI : 10.1016/j.mito.2006.07.006

P. Ward, L. Equinet, J. Packer, and C. Doerig, Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote, BMC Genomics, vol.5, issue.1, p.79, 2004.
DOI : 10.1186/1471-2164-5-79

URL : https://hal.archives-ouvertes.fr/inserm-00103327

S. Krishna, U. Eckstein-ludwig, T. Joet, A. Uhlemann, C. Morin et al., Transport processes in Plasmodium falciparum-infected erythrocytes: potential as new drug targets, International Journal for Parasitology, vol.32, issue.13, pp.321567-1573, 2002.
DOI : 10.1016/S0020-7519(02)00185-6

A. Schneider and O. Mercereau-puijalon, A new Apicomplexa-specific protein kinase family: multiple members in Plasmodium falciparum, all with an export signature, BMC Genomics, vol.6, issue.1, p.30, 2005.
DOI : 10.1186/1471-2164-6-30

M. Nunes, J. Goldring, C. Doerig, and A. Scherf, is differentially transcribed and secreted to various cellular compartments of the host cell, Molecular Microbiology, vol.207, issue.2, pp.391-403, 2007.
DOI : 10.1111/j.1365-2958.2006.05521.x

L. Roch, K. Johnson, J. Florens, L. Zhou, Y. Santrosyan et al., Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle, Genome Res, issue.11, pp.142308-2318, 2004.

N. Hall, M. Karras, J. Raine, J. Carlton, T. Kooij et al., A Comprehensive Survey of the Plasmodium Life Cycle by Genomic, Transcriptomic, and Proteomic Analyses, Science, vol.307, issue.5706, pp.30782-86, 2005.
DOI : 10.1126/science.1103717

R. Dzikowski, T. Templeton, and K. Deitsch, Variant antigen gene expression in malaria, Cellular Microbiology, vol.439, issue.9, pp.1371-1381, 2006.
DOI : 10.1016/S0166-6851(03)00004-5

K. Dechering, J. Thompson, H. Dodemont, W. Eling, and R. Konings, Developmentally regulated expression of pfs16, a marker for sexual differentiation of the human malaria parasite Plasmodium falciparum, Molecular and Biochemical Parasitology, vol.89, issue.2, pp.235-244, 1997.
DOI : 10.1016/S0166-6851(97)00123-0

J. Shock, K. Fischer, and J. Derisi, Whole-genome analysis of mRNA decay in Plasmodium falciparum reveals a global lengthening of mRNA half-life during the intra-erythrocytic development cycle, Genome Biology, vol.8, issue.7, p.134, 2007.
DOI : 10.1186/gb-2007-8-7-r134

R. Gamsjaeger, C. Liew, F. Loughlin, M. Crossley, and J. Mackay, Sticky fingers: zinc-fingers as protein-recognition motifs, Trends in Biochemical Sciences, vol.32, issue.2, pp.63-70, 2007.
DOI : 10.1016/j.tibs.2006.12.007

P. Stocks, P. Bray, V. Barton, M. Jones, M. Araujo et al., Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs, Angew Chem Int Ed Engl, issue.33, pp.466278-6283, 2007.

U. Eckstein-ludwig, R. Webb, V. Goethem, I. East, J. Lee et al., Artemisinins target the SERCA of Plasmodium falciparum, Nature, vol.424, issue.6951, pp.424957-961, 2003.
DOI : 10.1038/nature01813

E. Legrand, B. Volney, J. Meynard, O. Mercereau-puijalon, and P. Esterre, In Vitro Monitoring of Plasmodium falciparum Drug Resistance in French Guiana: a Synopsis of Continuous Assessment from 1994 to 2005, Antimicrobial Agents and Chemotherapy, vol.52, issue.1, pp.288-298, 1994.
DOI : 10.1128/AAC.00263-07

URL : https://hal.archives-ouvertes.fr/pasteur-00590986

K. Nagamune, W. Beatty, and L. Sibley, Artemisinin Induces Calcium-Dependent Protein Secretion in the Protozoan Parasite Toxoplasma gondii, Eukaryotic Cell, vol.6, issue.11, pp.2147-2156, 2007.
DOI : 10.1128/EC.00262-07

Y. Maeno, T. Toyoshima, H. Fujioka, Y. Ito, S. Meshnick et al., Morphologic effects of artemisinin in Plasmodium falciparum, Am J Trop Med Hyg, vol.49, issue.4, pp.485-491, 1993.

D. P. Crespo, M. Avery, T. Hanssen, E. Fox, E. Robinson et al., Artemisinin and a Series of Novel Endoperoxide Antimalarials Exert Early Effects on Digestive Vacuole Morphology, Antimicrobial Agents and Chemotherapy, vol.52, issue.1, pp.98-109, 2008.
DOI : 10.1128/AAC.00609-07

T. Akompong, J. Vanwye, N. Ghori, and K. Haldar, Artemisinin and its derivatives are transported by a vacuolar-network of Plasmodium falciparum and their anti-malarial activities are additive with toxic sphingolipid analogues that block the network, Molecular and Biochemical Parasitology, vol.101, issue.1-2, pp.71-79, 1999.
DOI : 10.1016/S0166-6851(99)00056-0

C. Van-ooij and K. Haldar, Protein export from Plasmodium parasites, Cellular Microbiology, vol.11, issue.3, pp.573-582, 2007.
DOI : 10.1016/S0092-8674(02)01250-3

M. Makanga, P. Bray, P. Horrocks, and S. Ward, Towards a proteomic definition of CoArtem action inPlasmodium falciparum malaria, PROTEOMICS, vol.70, issue.7, pp.1849-1858, 2005.
DOI : 10.1002/pmic.200401076

X. Pei, X. Guo, R. Coppel, N. Mohandas, and X. An, Plasmodium falciparum Erythrocyte Membrane Protein 3 (PfEMP3) Destabilizes Erythrocyte Membrane Skeleton, Journal of Biological Chemistry, vol.282, issue.37, pp.26754-26758, 2007.
DOI : 10.1074/jbc.M701612200

E. Knuepfer, M. Rug, N. Klonis, L. Tilley, and A. Cowman, Trafficking determinants for PfEMP3 export and assembly under the Plasmodium falciparum-infected red blood cell membrane

A. Maier, M. Rug, O. Neill, M. Brown, M. Chakravorty et al., Exported Proteins Required for Virulence and Rigidity of Plasmodium falciparum-Infected Human Erythrocytes, Cell, vol.134, issue.1, pp.48-61, 2008.
DOI : 10.1016/j.cell.2008.04.051

V. Anantharaman, L. Iyer, S. Balaji, and L. Aravind, Adhesion Molecules and Other Secreted Host???Interaction Determinants in Apicomplexa: Insights from Comparative Genomics, Int Rev Cytol, vol.262, pp.1-74, 2007.
DOI : 10.1016/S0074-7696(07)62001-4

T. Fandeur, S. Bonnefoy, and O. Mercereau-puijalon, In vivo and in vitro derived Palo Alto lines of Plasmodium falciparum are genetically unrelated, Molecular and Biochemical Parasitology, vol.47, issue.2, pp.167-178, 1991.
DOI : 10.1016/0166-6851(91)90176-7

S. Ralph, E. Bischoff, D. Mattei, O. Sismeiro, M. Dillies et al., Transcriptome analysis of antigenic variation in Plasmodium falciparum--var silencing is not dependent on antisense RNA, Genome Biology, vol.6, issue.11, p.93, 2005.
DOI : 10.1186/gb-2005-6-11-r93

R. Development and C. Team, R: A language and environment for statistical computing

R. Gentleman, V. Carey, D. Bates, B. Bolstad, M. Dettling et al., Bioconductor: open software development for computational biology and bioinformatics, Genome Biology, vol.5, issue.10, p.80, 2004.
DOI : 10.1186/gb-2004-5-10-r80

G. Smyth, Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments, Statistical Applications in Genetics and Molecular Biology, vol.3, issue.1, p.3, 2004.
DOI : 10.2202/1544-6115.1027

G. Smyth, R. Gentleman, V. Carey, S. Dudoit, R. Irizarry et al., limma: Linear Models for Microarray Data, In Bioinformatics and Computational Biology Solutions using R and Bioconductor Edited, pp.397-420, 2005.
DOI : 10.1007/0-387-29362-0_23

URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.182.2271

Y. Yang and N. Thorne, Normalization for two-color cDNA microarray data. Science and Statistics: A Festschrift for Terry Speed, IMS Lecture Notes -Monograph Series, pp.403-418, 2003.
DOI : 10.1214/lnms/1215091155

URL : http://projecteuclid.org/download/pdf_1/euclid.lnms/1215091155