Abstract : Background: Translocation of the CyaA toxin across plasma membrane is still poorly understood. Results: The region 375– 485 is involved in membrane destabilization in vitro and required for cell intoxication. Conclusion: The region 375– 485 is crucial for membrane insertion and translocation of the catalytic domain of CyaA. Significance: These results provide new insights on the early stages of the cell intoxication process.
https://hal-pasteur.archives-ouvertes.fr/pasteur-01423063
Contributor : Bénédicte Benedic <>
Submitted on : Wednesday, December 28, 2016 - 11:31:35 AM Last modification on : Monday, December 14, 2020 - 5:12:17 PM Long-term archiving on: : Monday, March 20, 2017 - 10:46:33 PM
File
Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed
until : jamais
Johanna C. Karst, Robert Barker, Usha Devi, Marcus J. Swann, Marilyne Davi, et al.. Identification of a Region That Assists Membrane Insertion and Translocation of the Catalytic Domain of Bordetella pertussis CyaA Toxin. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (12), pp.9200 - 9212. ⟨10.1074/jbc.M111.316166⟩. ⟨pasteur-01423063⟩