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Journal articles
Lineage Relationship Analysis of ROR t+ Innate Lymphoid Cells
Abstract : Abstract
Lymphoid tissue-inducer (LTi) cells initiate the development of lymphoid tissues through the activation of local stromal cells in a process similar to inflammation. LTi cells express the nuclear hormone receptor RORγt, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells. We show here that LTi cells are part of a larger family of proinflammatory RORγt(+) innate lymphoid cells (ILCs) that differentiate from distinct fetal liver RORγt(+) precursors. The fate of RORγt(+) ILCs is determined by mouse age, and after birth, favors the generation of cells involved in intestinal homeostasis and defense. Contrary to RORγt(+) T cells, however, RORγt(+) ILCs develop in the absence of microbiota. Our study indicates that RORγt(+) ILCs evolve to preempt intestinal colonization by microbial symbionts.
Comment in
Immunology. Innate lymphoid cell relations. [Science. 2010]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01402753
Contributor : Bérengère Hugot <>
Submitted on : Friday, November 25, 2016 - 10:17:43 AM
Last modification on : Thursday, June 18, 2020 - 5:38:02 PM
Contributor : Bérengère Hugot <>
Submitted on : Friday, November 25, 2016 - 10:17:43 AM
Last modification on : Thursday, June 18, 2020 - 5:38:02 PM