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Occupational prestige, social mobility and the association with lung cancer in men.

Thomas Behrens 1 Isabelle Groß 1 Jack Siemiatycki 2 David I Conway 3 Ann Olsson 4, 5 Isabelle Stücker 6 Florence Guida 6 Karl-Heinz Jöckel 7 Hermann Pohlabeln 8 Wolfgang Ahrens 9, 8 Irene Brüske 10 Heinz-Erich Wichmann 11, 10 Per Gustavsson 5 Dario Consonni 12 Franco Merletti 13 Lorenzo Richiardi 13 Lorenzo Simonato 14 Cristina Fortes 15 Marie-Elise Parent 16 John Mclaughlin 17 Paul Demers 18 Maria Teresa Landi 19 Neil Caporaso 19 David Zaridze 20 Neonila Szeszenia-Dabrowska 21 Peter Rudnai 22 Jolanta Lissowska 23 Eleonora Fabianova 24 Adonina Tardón 25 John K Field 26 Rodica Stanescu Dumitru 27 Vladimir Bencko 28 Lenka Foretova 29 Vladimir Janout 30 Hans Kromhout 31 Roel Vermeulen 31 Paolo Boffetta 32, 33 Kurt Straif 4 Joachim Schüz 4 Jan Hovanec 1 Benjamin Kendzia 1 Beate Pesch 1 Thomas Brüning 1
Abstract : The nature of the association between occupational social prestige, social mobility, and risk of lung cancer remains uncertain. Using data from the international pooled SYNERGY case-control study, we studied the association between lung cancer and the level of time-weighted average occupational social prestige as well as its lifetime trajectory. We included 11,433 male cases and 14,147 male control subjects. Each job was translated into an occupational social prestige score by applying Treiman's Standard International Occupational Prestige Scale (SIOPS). SIOPS scores were categorized as low, medium, and high prestige (reference). We calculated odds ratios (OR) with 95 % confidence intervals (CI), adjusting for study center, age, smoking, ever employment in a job with known lung carcinogen exposure, and education. Trajectories in SIOPS categories from first to last and first to longest job were defined as consistent, downward, or upward. We conducted several subgroup and sensitivity analyses to assess the robustness of our results. We observed increased lung cancer risk estimates for men with medium (OR = 1.23; 95 % CI 1.13-1.33) and low occupational prestige (OR = 1.44; 95 % CI 1.32-1.57). Although adjustment for smoking and education reduced the associations between occupational prestige and lung cancer, they did not explain the association entirely. Traditional occupational exposures reduced the associations only slightly. We observed small associations with downward prestige trajectories, with ORs of 1.13, 95 % CI 0.88-1.46 for high to low, and 1.24; 95 % CI 1.08-1.41 for medium to low trajectories. Our results indicate that occupational prestige is independently associated with lung cancer among men.
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Thomas Behrens, Isabelle Groß, Jack Siemiatycki, David I Conway, Ann Olsson, et al.. Occupational prestige, social mobility and the association with lung cancer in men.. BMC Cancer, BioMed Central, 2016, 16, pp.395. ⟨10.1186/s12885-016-2432-9⟩. ⟨pasteur-01350828⟩



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