J. Thiery, H. Acloque, R. Huang, and M. Nieto, Epithelial-Mesenchymal Transitions in Development and Disease, Cell, vol.139, issue.5, pp.871-890, 2009.
DOI : 10.1016/j.cell.2009.11.007

A. Cano, M. Perez-moreno, R. I. Locascio, A. Blanco, M. Del-barrio et al., The transcription factor Snail controls epithelial???mesenchymal transitions by repressing E-cadherin expression, Nature Cell Biology, vol.51, issue.2, pp.76-83, 2000.
DOI : 10.1006/dbio.1998.9047

K. Hajra, D. Chen, and E. Fearon, The SLUG zinc-finger protein represses E-cadherin in breast cancer, Cancer Res, vol.62, pp.1613-1618, 2002.

A. Barrallo-gimeno and M. Nieto, The Snail genes as inducers of cell movement and survival: implications in development and cancer, Development, vol.132, issue.14, pp.3151-3161, 2005.
DOI : 10.1242/dev.01907

S. Choi and A. Diehl, Epithelial-to-mesenchymal transitions in the liver, Hepatology, vol.135, issue.Suppl 1, pp.2007-2013, 2009.
DOI : 10.1002/hep.23196

C. Cicchini, D. Filippini, S. Coen, A. Marchetti, C. Cavallari et al., Snail controls differentiation of hepatocytes by repressing HNF4?? expression, Journal of Cellular Physiology, vol.98, issue.1, pp.230-238, 2006.
DOI : 10.1002/jcp.20730

C. Cicchini, I. Laudadio, F. Citarella, M. Corazzari, C. Steindler et al., TGF??-induced EMT requires focal adhesion kinase (FAK) signaling, Experimental Cell Research, vol.314, issue.1, pp.143-152, 2008.
DOI : 10.1016/j.yexcr.2007.09.005

A. Kaimori, J. Potter, J. Kaimori, C. Wang, E. Mezey et al., Transforming Growth Factor-beta1 Induces an Epithelial-to-Mesenchymal Transition State in Mouse Hepatocytes in Vitro, Journal of Biological Chemistry, vol.282, issue.30, pp.22089-22101, 2007.
DOI : 10.1074/jbc.M700998200

J. Sicklick, S. Choi, M. Bustamante, S. Mccall, and E. Perez, Evidence for epithelial-mesenchymal transitions in adult liver cells, AJP: Gastrointestinal and Liver Physiology, vol.291, issue.4, pp.575-583, 2006.
DOI : 10.1152/ajpgi.00102.2006

M. Battle, G. Konopka, F. Parviz, A. Gaggl, C. Yang et al., Hepatocyte nuclear factor 4?? orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver, Proceedings of the National Academy of Sciences, vol.103, issue.22, pp.8419-8424, 2006.
DOI : 10.1073/pnas.0600246103

F. Parviz, C. Matullo, W. Garrison, L. Savatski, J. Adamson et al., Hepatocyte nuclear factor 4?? controls the development of a hepatic epithelium and liver morphogenesis, Nature Genetics, vol.34, issue.3, pp.292-296, 2003.
DOI : 10.1038/ng1175

N. Lazarevich, O. Cheremnova, E. Varga, D. Ovchinnikov, E. Kudrjavtseva et al., Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors, Hepatology, vol.968, issue.4, pp.1038-1047, 2004.
DOI : 10.1002/hep.20155

H. Yue, C. Yin, J. Hou, X. Zeng, Y. Chen et al., Hepatocyte nuclear factor 4?? attenuates hepatic fibrosis in rats, Gut, vol.59, issue.2, pp.236-246, 2010.
DOI : 10.1136/gut.2008.174904

G. Hayhurst, Y. Lee, G. Lambert, J. Ward, and F. Gonzalez, Hepatocyte Nuclear Factor 4?? (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis, Molecular and Cellular Biology, vol.21, issue.4, pp.1393-1403, 2001.
DOI : 10.1128/MCB.21.4.1393-1403.2001

M. Colletti, C. Cicchini, A. Conigliaro, L. Santangelo, T. Alonzi et al., Convergence of Wnt Signaling on the HNF4??-Driven Transcription in Controlling Liver Zonation, Gastroenterology, vol.137, issue.2, pp.660-672, 2009.
DOI : 10.1053/j.gastro.2009.05.038

G. Spath and M. Weiss, Hepatocyte Nuclear Factor 4 Provokes Expression of Epithelial Marker Genes, Acting As a Morphogen in Dedifferentiated Hepatoma Cells, The Journal of Cell Biology, vol.16, issue.4, pp.935-946, 1998.
DOI : 10.1073/pnas.89.19.9069

M. Torres-padilla, C. Fougere-deschatrette, and M. Weiss, Expression of HNF4?? isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3??? end splicing, Mechanisms of Development, vol.109, issue.2, pp.183-193, 2001.
DOI : 10.1016/S0925-4773(01)00521-4

H. Peinado, M. Quintanilla, and A. Cano, Transforming Growth Factor ??-1 Induces Snail Transcription Factor in Epithelial Cell Lines, Journal of Biological Chemistry, vol.278, issue.23, pp.21113-21123, 2003.
DOI : 10.1074/jbc.M211304200

E. Batlle, E. Sancho, C. Franci, D. Dominguez, M. Monfar et al., The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells, Nature Cell Biology, vol.17, issue.2, pp.84-89, 2000.
DOI : 10.1083/jcb.111.3.1265

L. Amicone, F. Spagnoli, G. Spath, S. Giordano, C. Tommasini et al., Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes, The EMBO Journal, vol.16, issue.3, pp.495-503, 1997.
DOI : 10.1093/emboj/16.3.495

C. Kuo, P. Conley, L. Chen, F. Sladek, J. Darnell et al., A transcriptional hierarchy involved in mammalian cell-type specification, Nature, vol.355, issue.6359, pp.457-461, 1992.
DOI : 10.1038/355457a0

J. Eeckhoute, P. Formstecher, and B. Laine, Hepatocyte Nuclear Factor 4?? enhances the Hepatocyte Nuclear Factor 1??-mediated activation of transcription, Nucleic Acids Research, vol.32, issue.8, pp.2586-2593, 2004.
DOI : 10.1093/nar/gkh581

C. Rowley, L. Staloch, J. Divine, S. Mccaul, and T. Simon, Mechanisms of mutual functional interactions between HNF-4alpha and HNF-1alpha revealed by mutations that cause maturity onset diabetes of the young

D. Odom, N. Zizlsperger, D. Gordon, G. Bell, N. Rinaldi et al., Control of Pancreas and Liver Gene Expression by HNF Transcription Factors, Science, vol.303, issue.5662, pp.1378-1381, 2004.
DOI : 10.1126/science.1089769

S. Thuault, U. Valcourt, M. Petersen, G. Manfioletti, and C. Heldin, Transforming growth factor-?? employs HMGA2 to elicit epithelial???mesenchymal transition, The Journal of Cell Biology, vol.164, issue.2, pp.175-183, 2006.
DOI : 10.1038/sj.emboj.7600069

URL : https://hal.archives-ouvertes.fr/hal-00314880

M. Nagaki and H. Moriwaki, Transcription factor HNF and hepatocyte differentiation, Hepatology Research, vol.44, issue.10, pp.961-969, 2008.
DOI : 10.1111/j.1872-034X.2008.00367.x

V. Stanulovic, I. Kyrmizi, M. Kruithof-de-julio, M. Hoogenkamp, and J. Vermeulen, Hepatic HNF4alpha deficiency induces periportal expression of glutamine synthetase and other pericentral enzymes, HEPA- TOLOGY, vol.45, pp.433-444, 2007.

S. Satohisa, H. Chiba, M. Osanai, S. Ohno, T. Kojima et al., Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4??-induced epithelial polarization, Experimental Cell Research, vol.310, issue.1, pp.66-78, 2005.
DOI : 10.1016/j.yexcr.2005.06.025

E. Bolotin, H. Liao, T. Ta, C. Yang, and W. Hwang-verslues, Integrated approach for the identification of human hepatocyte nuclear factor 4?? target genes using protein binding microarrays, Hepatology, vol.4, issue.9, pp.642-653, 2010.
DOI : 10.1002/hep.23357

M. Fraga, M. Herranz, J. Espada, E. Ballestar, and M. Paz, A Mouse Skin Multistage Carcinogenesis Model Reflects the Aberrant DNA Methylation Patterns of Human Tumors, Cancer Research, vol.64, issue.16, pp.5527-5534, 2004.
DOI : 10.1158/0008-5472.CAN-03-4061

L. Pelletier, S. Rebouissou, A. Paris, E. Rathahao-paris, E. Perdu et al., Loss of hepatocyte nuclear factor 1?? function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis, Hepatology, vol.15, issue.2, pp.557-566, 2010.
DOI : 10.1002/hep.23362

URL : https://hal.archives-ouvertes.fr/hal-01173782