African apes as reservoirs of Plasmodium falciparum and the origin and diversification of the Laverania subgenus. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2010

African apes as reservoirs of Plasmodium falciparum and the origin and diversification of the Laverania subgenus.

Résumé

We investigated two mitochondrial genes (cytb and cox1), one plastid gene (tufA), and one nuclear gene (ldh) in blood samples from 12 chimpanzees and two gorillas from Cameroon and one lemur from Madagascar. One gorilla sample is related to Plasmodium falciparum, thus confirming the recently reported presence in gorillas of this parasite. The second gorilla sample is more similar to the recently defined Plasmodium gaboni than to the P. falciparum-Plasmodium reichenowi clade, but distinct from both. Two chimpanzee samples are P. falciparum. A third sample is P. reichenowi and two others are P. gaboni. The other chimpanzee samples are different from those in the ape clade: two are Plasmodium ovale, and one is Plasmodium malariae. That is, we have found three human Plasmodium parasites in chimpanzees. Four chimpanzee samples were mixed: one species was P. reichenowi; the other species was P. gaboni in three samples and P. ovale in the fourth sample. The lemur sample, provisionally named Plasmodium malagasi, is a sister lineage to the large cluster of primate parasites that does not include P. falciparum or ape parasites, suggesting that the falciparum + ape parasite cluster (Laverania clade) may have evolved from a parasite present in hosts not ancestral to the primates. If malignant malaria were eradicated from human populations, chimpanzees, in addition to gorillas, might serve as a reservoir for P. falciparum.
Fichier sous embargo
Fichier sous embargo
Date de visibilité indéterminée
Loading...

Dates et versions

pasteur-00835704 , version 1 (19-06-2013)

Identifiants

Citer

Linda Duval, Mathieu Fourment, Eric Nerrienet, Dominique Rousset, Serge A Sadeuh, et al.. African apes as reservoirs of Plasmodium falciparum and the origin and diversification of the Laverania subgenus.. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (23), pp.10561-6. ⟨10.1073/pnas.1005435107⟩. ⟨pasteur-00835704⟩
137 Consultations
2 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More