Acute risk for hepatitis E virus infection among HIV-1-positive pregnant women in central Africa.

Mélanie Caron (1) , Julie Bouscaillou (2) , Mirdad Kazanji (1, 2)

1 Unité de Rétrovirologie
2 Institut Pasteur de Bangui

UNLABELLED: ABSTRACT: BACKGROUND: Hepatitis E virus (HEV), an enterically transmitted pathogen, is highly endemic in several African countries. Pregnant women are at particularly high risk for acute or severe hepatitis E. In Gabon, a central African country, the prevalence of antibodies to HEV among pregnant women is 14.1%. Recent studies have demonstrated unusual patterns of hepatitis E (chronic hepatitis, cirrhosis) among immunodeficient patients. FINDINGS: We investigated the prevalence of antibodies to HEV among pregnant women infected with HIV-1 or HTLV-1 in Gabon. Of 243 samples collected, 183 were positive for HIV-1 and 60 for HTLV-1; 16 women (6.6%) had IgG antibodies to HEV. The seroprevalence was higher among HIV-1-infected women (7.1%) than HTLV-1-infected women (5.0%). Moreover, the HIV-1 viral load was significantly increased (p ≤ 0.02) among women with past-HEV exposure (1.3E+05 vs 5.7E+04 copies per ml), whereas no difference was found in HTLV-1 proviral load (9.0E+01 vs 1.1E+03 copies per ml). CONCLUSIONS: These data provide evidence that HIV-1-infected women are at risk for acute or severe infection if they are exposed to HEV during pregnancy, with an increased viral load.

Domaines: Maladies infectieuses

Mélanie Caron, Julie Bouscaillou, Mirdad Kazanji. Acute risk for hepatitis E virus infection among HIV-1-positive pregnant women in central Africa.. Virology Journal, 2012, 9 (1), pp.254. ⟨10.1186/1743-422X-9-254⟩. ⟨pasteur-00750980⟩