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Article Dans Une Revue Nature Immunology Année : 2006

A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127.

Résumé

Natural killer (NK) cell development is thought to occur in the bone marrow. Here we identify the transcription factor GATA-3 and CD127 (IL-7R alpha) as molecular markers of a pathway of mouse NK cell development that originates in the thymus. Thymus-derived CD127+ NK cells repopulated peripheral lymphoid organs, and their homeostasis was strictly dependent on GATA-3 and interleukin 7. The CD127+ NK cells had a distinct phenotype (CD11b(lo) CD16- CD69(hi) Ly49(lo)) and unusual functional attributes, including reduced cytotoxicity but considerable cytokine production. Those characteristics are reminiscent of human CD56(hi) CD16- NK cells, which we found expressed CD127 and had more GATA-3 expression than human CD56+ CD16+ NK cells. We propose that bone marrow and thymic NK cell pathways generate distinct mouse NK cells with properties similar to those of the two human CD56 NK cell subsets.

Domaines

Immunologie

Dates et versions

pasteur-00362040 , version 1 (17-02-2009)

Identifiants

Citer

Christian A. J. Vosshenrich, Marcos E. García-Ojeda, Sandrine I. Samson-Villéger, Valerie Pasqualetto, Laurence Enault, et al.. A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127.. Nature Immunology, 2006, 7 (11), pp.1217-24. ⟨10.1038/ni1395⟩. ⟨pasteur-00362040⟩
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