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Article Dans Une Revue Immunology Letters Année : 2002

Cyclosporin A therapy differently affects immunological-relevant gene expression following immunization.

Résumé

We have studied the effect of cyclosporin A (CSA) on the expression of genes involved in the immune response in mice bearing a transgenic T cell receptor specific for the peptide 88-104 of the pigeon cytochrome c. Immunization of mice treated with CSA resulted in the blockade of the IL2, IFN-gamma, CXCR-5, CCR-5 and CD25 gene transcription. CSA decreased the density of CD69 on T-cells but did not interfere with the induction of the chemokine receptors CCR-1, CCR-4, CXCR2 and CXCR-4. Finally, CSA accelerated the kinetics of CD44 and CD62L expression or re-expression and increased the density of both markers on T-cell membrane. The present data show that priming in presence of CSA resulted in the acquisition of a particular phenotype by the activated T-cells.

Domaines

Immunologie

Dates et versions

pasteur-00327455 , version 1 (08-10-2008)

Identifiants

Citer

Laurent Mascarell, Paolo Truffa-Bachi. Cyclosporin A therapy differently affects immunological-relevant gene expression following immunization.. Immunology Letters, 2002, 84 (2), pp.137-43. ⟨10.1016/S0165-2478(02)00157-8⟩. ⟨pasteur-00327455⟩
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