Upregulation of PPARβ/δ Is Associated with Structural and Functional Changes in the Type I Diabetes Rat Diaphragm

Nadège Salvi (1) , Aziz Guellich (2) , Pierre Michelet (1) , Alexandre Demoule (3) , Morgan Le Guen (1, 3) , Laure Renou (4) , Gisèle Bonne (5) , Bruno Riou (6, 1) , Olivier Langeron (3, 1) , Catherine Coirault (7)

1 Génétique, pharmacologie et physiopathologie des maladies cardiovasculaires
2 Unité fonctionnelle insuffisance cardiaque
3 CHU Pitié-Salpêtrière [AP-HP]
4 Thérapie des maladies du muscle strié
5 Centre de recherche en Myologie – U974 SU-INSERM
6 UPMC - Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie
7 Centre de recherche en myologie

Background: Diabetes mellitus is associated with alterations in peripheral striated muscles and cardiomyopathy. We examined diaphragmatic function and fiber composition and identified the role of peroxisome proliferator-activated receptors (PPAR a and b/d) as a factor involved in diaphragm muscle plasticity in response to type I diabetes.

Domaines: Sciences du Vivant [q-bio]

Nadège Salvi, Aziz Guellich, Pierre Michelet, Alexandre Demoule, Morgan Le Guen, et al.. Upregulation of PPARβ/δ Is Associated with Structural and Functional Changes in the Type I Diabetes Rat Diaphragm. PLoS ONE, 2010, 5 (7), pp.e11494. ⟨10.1371/journal.pone.0011494⟩. ⟨inserm-02426556⟩