B. P. O'sullivan and S. D. Freedman, Cystic fibrosis, Lancet, vol.373, pp.1891-1904, 2009.

J. R. Riordan, J. M. Rommens, and B. Kerem, Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA, Science, vol.245, issue.4925, pp.1066-1073, 1437.

M. P. Anderson, R. J. Gregory, and S. Thompson, Demonstration that CFTR is a chloride channel by alteration of its anion selectivity, Science, vol.253, pp.202-205, 1991.

G. R. Cutting, Cystic fibrosis genetics: from molecular understanding to clinical application, Nat Rev Genet, vol.16, pp.45-56, 2015.

R. C. Boucher, An overview of the pathogenesis of cystic fibrosis lung disease, Adv Drug Deliv Rev, vol.54, pp.1359-1371, 2002.

O. Tabary, J. M. Zahm, and J. Hinnrasky, Selective up-regulation of chemokine IL-8 expression in cystic fibrosis bronchial gland cells in vivo and in vitro, Am J Pathol, vol.153, pp.921-930, 1998.

T. S. Cohen and A. Prince, Cystic fibrosis: a mucosal immunodeficiency syndrome, Nat Med, vol.18, pp.509-519, 2012.

J. Jacquot, O. Tabary, L. Rouzic, and P. , Airway epithelial cell inflammatory signalling in cystic fibrosis, Int J Biochem Cell Biol, vol.40, pp.1703-1715, 2008.

R. Tirouvanziam, S. De-bentzmann, and C. Hubeau, Inflammation and infection in naive human cystic fibrosis airway grafts, Am J Respir Cell Mol Biol, vol.23, pp.121-127, 2000.

M. Karin, The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation, J Biol Chem, vol.274, pp.27339-27342, 1999.

O. Tabary, E. Boncoeur, and R. De-martin, Calcium-dependent regulation of NF-(kappa)B activation in cystic fibrosis airway epithelial cells, Cell Signal, vol.18, pp.652-660, 2006.

J. Jacquot, O. Tabary, and A. Clement, Hyperinflammation in airways of cystic fibrosis patients: what's new?, Expert Rev Mol Diagn, vol.8, pp.359-363, 2008.

H. Arora, R. Qureshi, and S. Jin, miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFkappaB1, Exp Mol Med, vol.43, pp.298-304, 2011.

K. Poos, J. Smida, and M. Nathrath, How microRNA and transcription factor co-regulatory networks affect osteosarcoma cell proliferation, PLoS Comput Biol, vol.9, p.1003210, 2013.

Y. Yang and J. Wang, The functional analysis of microRNAs involved in NF-?B signaling, Eur Rev Med Pharmacol Sci, vol.20, pp.1764-1774, 2016.

W. Filipowicz, S. N. Bhattacharyya, and N. Sonenberg, Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?, Nat Rev Genet, vol.9, pp.102-114, 2008.

R. C. Friedman, K. K. Farh, and C. B. Burge, Most mammalian mRNAs are conserved targets of microRNAs, Genome Res, vol.19, pp.92-105, 2009.

L. Dai, L. Gu, and W. Di, MiR-199a attenuates endometrial stromal cell invasiveness through suppression of the IKKbeta/NF-kappaB pathway and reduced interleukin-8 expression, Mol Hum Reprod, vol.18, pp.136-145, 2012.

K. A. Byrnes, P. Phatak, and D. Mansour, Overexpression of miR-199a-5p decreases esophageal cancer cell proliferation through repression of mitogen-activated protein kinase kinase kinase-11 (MAP3K11), Oncotarget, vol.7, pp.8756-8770, 2016.

P. S. Foster, M. Plank, and A. Collison, The emerging role of microRNAs in regulating immune and inflammatory responses in the lung, Immunol Rev, vol.253, pp.198-215, 2013.

S. Ramachandran, P. H. Karp, and S. R. Osterhaus, Post-transcriptional regulation of cystic fibrosis transmembrane conductance regulator expression and function by microRNAs, Am J Respir Cell Mol Biol, vol.49, pp.544-551, 2013.

F. Sonneville, M. Ruffin, and L. Guillot, New insights about miRNAs in cystic fibrosis, Am J Pathol, 2015.

L. Wiszniewski, L. Jornot, and T. Dudez, Long-term cultures of polarized airway epithelial cells from patients with cystic fibrosis, Am J Respir Cell Mol Biol, vol.34, pp.39-48, 2006.

V. Balloy, H. Varet, and M. A. Dillies, Normal and cystic fibrosis human bronchial epithelial cells infected with Pseudomonas aeruginosa exhibit distinct gene activation patterns, PLoS One, vol.10, p.140979, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01277894

K. V. Pandit, D. Corcoran, and H. Yousef, Inhibition and role of let-7d in idiopathic pulmonary fibrosis, Am J Respir Crit Care Med, vol.182, pp.220-229, 2010.

P. Chomczynski and N. Sacchi, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal Biochem, vol.162, pp.156-159, 1987.

R. Chen, A. B. Alvero, and D. A. Silasi, Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells, Oncogene, vol.27, pp.4712-4723, 2008.

N. Dahiya, C. A. Sherman-baust, and T. L. Wang, MicroRNA expression and identification of putative miRNA targets in ovarian cancer, PLoS One, vol.3, p.2436, 2008.

M. Inomata, H. Tagawa, and Y. M. Guo, MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes, Blood, vol.113, pp.396-402, 2009.

M. N. Becker, M. S. Sauer, and M. S. Muhlebach, Cytokine secretion by cystic fibrosis airway epithelial cells, Am J Respir Crit Care Med, vol.169, pp.645-653, 2004.

I. K. Oglesby, I. M. Bray, and S. H. Chotirmall, miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression, J Immunol, vol.184, pp.1702-1709, 2010.

S. Ramachandran, P. H. Karp, and P. Jiang, A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator, Proc Natl Acad Sci U S A, vol.109, pp.13362-13367, 2012.

C. Muselet-charlier, T. Roque, and E. Boncoeur, Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling, Biochem Biophys Res Commun, vol.357, pp.402-407, 2007.

C. M. Ribeiro, The role of intracellular calcium signals in inflammatory responses of polarised cystic fibrosis human airway epithelia, Drugs R D, vol.7, pp.17-31, 2006.

F. Antigny, C. Norez, and F. Becq, CFTR and Ca signaling in cystic fibrosis, Front Pharmacol, vol.2, p.67, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00664651

P. X. Zhang, J. Cheng, and S. Zou, Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation, Nat Commun, vol.6, p.6221, 2015.

X. Sun, Y. C. Ruan, and J. Guo, Regulation of miR-101/miR-199a-3p by the epithelial sodium channel during embryo implantation: involvement of CREB phosphorylation, Reproduction, vol.148, pp.559-568, 2014.

A. Magenta, E. Dellambra, and R. Ciarapica, Oxidative stress, microRNAs and cytosolic calcium homeostasis, Cell Calcium, vol.60, pp.207-217, 2016.

F. Finger and T. Hoppe, MicroRNAs meet calcium: joint venture in ER proteostasis, Sci Signal, vol.7, p.11, 2014.

M. Harada, X. Luo, and T. Murohara, MicroRNA regulation and cardiac calcium signaling: role in cardiac disease and therapeutic potential, Circ Res, vol.114, pp.689-705, 2014.

M. Teta, Y. S. Choi, and T. Okegbe, Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin, Development, vol.139, pp.1405-1416, 2012.

X. Ma, L. E. Becker-buscaglia, and J. R. Barker, MicroRNAs in NF-kappaB signaling, J Mol Cell Biol, vol.3, pp.159-166, 2011.

S. Lu, H. Liu, J. M. Farley, and . Sr, Macrolide antibiotics inhibit mucus secretion and calcium entry in Swine airway submucosal mucous gland cells, J Pharmacol Exp Ther, vol.336, pp.178-187, 2011.

L. Q. Wang, Y. L. Kwong, and C. S. Kho, Epigenetic inactivation of miR-9 family microRNAs in chronic lymphocytic leukemia--implications on constitutive activation of NFkappaB pathway, Mol Cancer, vol.12, p.173, 2013.

L. M. Guo, Y. Pu, and Z. Han, MicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-kappaB1, FEBS J, vol.276, pp.5537-5546, 2009.

G. D. Liu, H. Zhang, and L. Wang, Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells, Int J Ophthalmol, vol.6, pp.280-285, 2013.

E. Fabbri, M. Borgatti, and G. Montagner, Expression of miR-93 and Interleukin-8 during Pseudomonas aeruginosa-mediated induction of pro-inflammatory responses, Am J Respir Cell Mol Biol, vol.50, pp.1144-1155, 2014.

E. F. Dosunmu, R. O. Emeh, and S. Dixit, The anti-microbial peptide TP359 attenuates inflammation in human lung cells infected with Pseudomonas aeruginosa via TLR5 and MAPK pathways, PLoS One, vol.12, p.176640, 2017.

Z. W. Dong, J. Chen, and Y. C. Ruan, CFTR-regulated MAPK/NF-kappaB signaling in pulmonary inflammation in thermal inhalation injury, Sci Rep, vol.5, p.15946, 2015.

M. S. Alexander, G. Kawahara, and N. Motohashi, MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation, Cell Death Differ, vol.20, pp.1194-1208, 2013.

X. Pan, B. Jiang, and J. Liu, STC1 promotes cell apoptosis via NF-kappaB phospho-P65 Ser536 in cervical cancer cells, Oncotarget, vol.8, pp.46249-46261, 2017.

R. Wang, M. Zhang, and W. Zhou, NF-kappaB signaling inhibits ubiquitin carboxyl-terminal hydrolase L1 gene expression, J Neurochem, vol.116, pp.1160-1170, 2011.

T. Wang, X. He, and X. Liu, Weighted gene co-expression network analysis identifies FKBP11 as a key regulator in acute aortic dissection through a NF-kB dependent pathway, Front Physiol, vol.8, p.1010, 2017.

V. T. Puliyappadamba, K. J. Hatanpaa, and S. Chakraborty, The role of NF-kappaB in the pathogenesis of glioma, Mol Cell Oncol, vol.1, p.963478, 2014.

C. D. House, E. Jordan, and L. Hernandez, NFkappaB promotes ovarian tumorigenesis via classical pathways that support proliferative cancer cells and alternative pathways that support ALDH(+) cancer stem-like cells, Cancer Res, vol.77, pp.6927-6940, 2017.

M. Iwanaszko, A. R. Brasier, and M. Kimmel, The dependence of expression of NF-kappaBdependent genes: statistics and evolutionary conservation of control sequences in the promoter and in the 3' UTR, BMC Genomics, vol.13, p.182, 2012.

E. A. Barbu, J. Zhang, and E. H. Berenstein, The transcription factor Zeb2 regulates signaling in mast cells, J Immunol, vol.188, pp.6278-6286, 2012.

M. Chesi and P. L. Bergsagel, Advances in the pathogenesis and diagnosis of multiple myeloma, Int J Lab Hematol, vol.37, issue.1, pp.108-114, 2015.

G. Bredholt, M. Mannelqvist, and I. M. Stefansson, Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responses, Oncotarget, vol.6, pp.39676-39691, 2015.

N. Xiang, M. He, and M. Ishaq, The DEAD-Box RNA helicase DDX3 interacts with NF-kappaB subunit p65 and suppresses p65-mediated transcription, PLoS One, vol.11, p.164471, 2016.

M. Zong, X. G. Wu, and C. W. Chan, The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability, PLoS One, vol.6, p.23350, 2011.