P. J. Shepard and K. J. Hertel, The SR protein family, Genome Biol, vol.10, p.242, 2009.

J. C. Long and J. F. Caceres, The SR protein family of splicing factors: master regulators of gene expression, Biochem J, vol.417, pp.15-27, 2009.

S. Stamm, Regulation of alternative splicing by reversible protein phosphorylation, J Biol Chem, vol.283, pp.1223-1230, 2008.

J. Wang, Y. Takagaki, and J. L. Manley, Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability, Genes Dev, vol.10, pp.2588-99, 1996.

S. Lin, R. Xiao, P. Sun, X. Xu, and X. D. Fu, Dephosphorylationdependent sorting of SR splicing factors during mRNP maturation, Mol Cell, vol.20, pp.413-438, 2005.

T. Moroy and F. Heyd, The impact of alternative splicing in vivo: mouse models show the way, RNA, vol.13, pp.1155-71, 2007.

X. Li and J. L. Manley, Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability, Cell, vol.122, pp.365-78, 2005.

S. Tuduri, L. Crabbe, C. Conti, H. Tourriere, H. Holtgreve-grez et al., Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription, Nat Cell Biol, vol.11, pp.1315-1339, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00533325

R. Xiao, Y. Sun, J. H. Ding, S. Lin, D. W. Rose et al., Splicing regulator SRSF2 is essential for genomic stability and cell proliferation during mammalian organogenesis, Mol Cell Biol, vol.27, pp.5393-402, 2007.

Z. H. Jiang, W. J. Zhang, Y. Rao, and J. Y. Wu, Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors, Proc Natl Acad Sci, vol.95, pp.9155-60, 1998.

X. Li, J. Wang, and J. L. Manley, Loss of splicing factor ASF/ SF2 induces G 2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation, Genes Dev, vol.19, pp.2705-2719, 2005.

G. Merdzhanova, V. Edmond, D. Seranno, S. Van-den-broeck, A. Corcos et al., E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SRSF2, Cell Death Differ, vol.15, pp.1815-1838, 2008.

C. Ghigna, M. Moroni, C. Porta, S. Riva, and G. Biamonti, Altered expression of heterogenous nuclear ribonucleoproteins and SR factors in human colon adenocarcinomas, Cancer Res, vol.58, pp.5818-5842, 1998.

E. Stickeler, F. Kittrell, D. Medina, and S. M. Berget, Stagespecific changes in SR splicing factors and alternative splicing in mammary tumorigenesis, Oncogene, vol.18, pp.3574-82, 1999.

D. C. Fischer, K. Noack, I. B. Runnebaum, D. O. Watermann, D. G. Kieback et al., Expression of splicing factors in human ovarian cancer, Oncol Rep, vol.11, pp.1085-90, 2004.

R. Karni, E. De-stanchina, S. W. Lowe, R. Sinha, D. Mu et al., The gene encoding the splicing factor SRSF1 is a proto-oncogene, Nat Struct Mol Biol, vol.14, pp.185-93, 2007.

R. W. Johnstone, Histone-deacetylase inhibitors: novel drugs for the treatment of cancer, Nat Rev Drug Discov, vol.1, pp.287-99, 2002.

S. Minucci and P. G. Pelicci, Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer, Nat Rev Cancer, vol.6, pp.38-51, 2006.

P. A. Marks, V. M. Richon, and R. A. Rifkind, Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells, J Natl Cancer Inst, vol.92, pp.1210-1216, 2000.

M. J. Peart, K. M. Tainton, A. A. Ruefli, A. E. Dear, K. A. Sedelies et al., Novel mechanisms of apoptosis induced by histone deacetylase inhibitors, Cancer Res, vol.63, pp.4460-71, 2003.

R. Piekarz and S. Bates, A review of depsipeptide and other histone deacetylase inhibitors in clinical trials, Curr Pharm Des, vol.10, pp.2289-98, 2004.

S. Y. Archer, S. Meng, A. Shei, and R. A. Hodin, p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells, Proc Natl Acad Sci, vol.95, pp.6791-6797, 1998.

V. M. Richon, T. W. Sandhoff, R. A. Rifkind, and P. A. Marks, Histone deacetylase inhibitor selectively induces p21 WAF1 expression and gene-associated histone acetylation, Proc Natl Acad Sci, vol.97, pp.10014-10023, 2000.

C. Y. Gui, L. Ngo, W. S. Xu, V. M. Richon, and P. A. Marks, Histone deacetylase (HDAC) inhibitor activation of p21 WAF1 involves changes in promoter-associated proteins, including HDAC1, Proc Natl Acad Sci, vol.101, pp.1241-1247, 2004.

R. Varshochi, F. Halim, A. Sunters, J. P. Alao, P. A. Madureira et al., 780 induces p21 Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line, J Biol Chem, vol.280, pp.3185-96, 2005.

J. G. Chang, H. M. Hsieh-li, Y. J. Jong, N. M. Wang, C. H. Tsai et al., Treatment of spinal muscular atrophy by sodium butyrate, Proc Natl Acad Sci, vol.98, pp.9808-9821, 2001.

M. Nissim-rafinia, M. Aviram, S. H. Randell, L. Shushi, E. Ozeri et al., Restoration of the cystic fibrosis transmembrane conductance regulator function by splicing modulation, EMBO Rep, vol.5, pp.1071-1078, 2004.

V. Edmond, E. Moysan, S. Khochbin, P. Matthias, C. Brambilla et al., Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin, EMBO J, vol.30, pp.510-533, 2011.

E. Lee, T. Furukubo, T. Miyabe, A. Yamauchi, and K. Kariya, Involvement of histone hyperacetylation in triggering DNA fragmentation of rat thymocytes undergoing apoptosis, FEBS Lett, vol.395, pp.183-190, 1996.

J. A. Mcbain, A. Eastman, C. S. Nobel, and G. C. Mueller, Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors, Biochem Pharmacol, vol.53, pp.1357-68, 1997.

V. Medina, B. Edmonds, G. P. Young, R. James, S. Appleton et al., Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/ cytochrome c-dependent pathway, Cancer Res, vol.57, pp.3697-707, 1997.

R. A. Steinman, B. Hoffman, A. Iro, C. Guillouf, D. A. Liebermann et al., Induction of p21 (WAF-1/CIP1) during differentiation, Oncogene, vol.9, pp.3389-96, 1994.

C. Buquet-fagot, F. Lallemand, R. H. Charollais, and J. Mester, Sodium butyrate inhibits the phosphorylation of the retinoblastoma gene product in mouse fibroblasts by a transcription-dependent mechanism, J Cell Physiol, vol.166, pp.631-637, 1996.

K. Nakano, T. Mizuno, Y. Sowa, T. Orita, T. Yoshino et al., Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line, J Biol Chem, vol.272, pp.22199-206, 1997.

Y. Terao, J. Nishida, S. Horiuchi, F. Rong, Y. Ueoka et al., Sodium butyrate induces growth arrest and senescence-like phenotypes in gynecologic cancer cells, Int J Cancer, vol.94, pp.257-67, 2001.

T. Inoue, K. Kato, H. Kato, K. Asanoma, A. Kuboyama et al., Level of reactive oxygen species induced by p21 Waf1/CIP1 is critical for the determination of cell fate, Cancer Sci, vol.100, pp.1275-83, 2009.

M. V. Abramova, T. V. Pospelova, F. P. Nikulenkov, C. M. Hollander, A. J. Fornace et al., G 1 /S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through downregulation of E2F activity and stabilization of beta-catenin, J Biol Chem, vol.281, pp.21040-51, 2006.

K. Hubbard, S. N. Dhanaraj, K. A. Sethi, J. Rhodes, J. Wilusz et al., Alteration of DNA and RNA binding activity of human telomere binding proteins occurs during cellular senescence, Exp Cell Res, vol.218, pp.241-248, 1995.

D. Zhu, G. Xu, S. Ghandhi, and K. Hubbard, Modulation of the expression of p16 INK4a and p14 ARF by hnRNP A1 and A2 RNA binding proteins: implications for cellular senescence, J Cell Physiol, vol.193, pp.19-25, 2002.

Y. Ito, T. Ide, and Y. Mitsui, Expressional changes in alternative splicing affecting genes during cell passage of human diploid fibroblasts, Mech Ageing Dev, vol.105, pp.105-119, 1998.

C. Salon, B. Eymin, O. Micheau, L. Chaperot, J. Plumas et al., E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptormediated apoptosis through specific downregulation of c-FLIP(short), Cell Death Differ, vol.13, pp.260-72, 2006.

K. Berns, E. M. Hijmans, J. Mullenders, T. R. Brummelkamp, A. Velds et al., A large-scale RNAi screen in human cells identifies new components of the p53 pathway, Nature, vol.428, pp.431-438, 2004.

G. Legube, L. K. Linares, S. Tyteca, C. Caron, M. Scheffner et al., Role of the histone acetyl transferase TIP60 in the p53 pathway, J Biol Chem, vol.279, pp.44825-44858, 2004.
URL : https://hal.archives-ouvertes.fr/hal-00320114

S. Tyteca, M. Vandromme, G. Legube, M. Chevillard-briet, and D. Trouche, Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression, EMBO J, vol.25, pp.1680-1689, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00317897

N. Gevry, H. M. Chan, L. Laflamme, D. M. Livingston, and L. Gaudreau, p21 transcription is regulated by differential localization of histone H2A, Z. Genes Dev, vol.21, pp.1869-81, 2007.

J. H. Park, X. J. Sun, and R. G. Roeder, The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression, Mol Cell Biol, vol.30, pp.2750-61, 2010.

B. D. Chang, K. Watanabe, E. V. Broude, J. Fang, J. C. Poole et al., Effects of p21 Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence and age-related diseases, Proc Natl Acad Sci, vol.97, pp.4291-4297, 2000.

T. V. Pospelova, Z. N. Demidenko, E. I. Bukreeva, V. A. Pospelov, A. V. Gudkov et al., Pseudo-DNA damage response in senescent cells, Cell Cycle, vol.8, pp.4112-4120, 2009.

L. K. Zerbe, I. Pino, R. Pio, P. F. Cosper, L. D. Dwyer-nield et al., Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing, Mol Carcinog, vol.41, pp.187-96, 2004.

Y. Dai, M. Rahmani, and S. Grant, An intact NFkappaB pathway is required for histone deacetylase inhibitorinduced G 1 arrest and maturation in U937 human myeloid leukemia cells, Cell Cycle, vol.2, pp.467-72, 2003.

H. Kobayashi, E. M. Tan, and S. E. Fleming, Sodium butyrate inhibits cell growth and stimulates p21 WAF1/CIP1 protein in human colonic adenocarcinoma cells independently of p53 status, Nutr Cancer, vol.46, pp.202-213, 2003.

P. Rocchi, R. Tonelli, C. Camerin, S. Purgato, R. Fronza et al., p21 Waf1/Cip1 is a common target induced by short-chain fatty acid HDAC inhibitors (valproic acid, tributyrin and sodium butyrate) in neuroblastoma cells, Oncol Rep, vol.13, pp.1139-1183, 2005.

S. Lee, J. R. Park, M. S. Seo, K. H. Roh, S. B. Park et al., Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells, Cell Prolif, vol.42, pp.711-731, 2009.