Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22, Nat. Immunol, vol.12, pp.383-390, 2011. ,
IL-22 increases the innate immunity of tissues, Immunity, vol.21, pp.241-254, 2004. ,
Interleukin 22 (IL-22) plays a protective role in T cellmediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation, Hepatology, vol.39, pp.1332-1342, 2004. ,
Acinar cells of the pancreas are a target of interleukin-22, J. Interferon Cytokine Res, vol.21, pp.1047-1053, 2001. ,
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens, Nat. Med, vol.14, pp.282-289, 2008. ,
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia, Nat. Med, vol.14, pp.275-281, 2008. ,
?? T cells protect against lung fibrosis via IL-22, J. Exp. Med, vol.207, pp.2239-2253, 2010. ,
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis, J. Clin. Invest, vol.118, pp.534-544, 2008. ,
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease, Immunity, vol.29, pp.947-957, 2008. ,
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis, Nature, vol.445, pp.648-651, 2007. ,
Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice, Arthritis Rheum, vol.60, pp.390-395, 2009. ,
Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17, J. Exp. Med, vol.206, pp.3047-3059, 2009. ,
Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A, J. Exp. Med, vol.207, pp.1293-1305, 2010. ,
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides, J. Exp. Med, vol.203, pp.2271-2279, 2006. ,
Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22, J. Immunol, vol.166, pp.7090-7095, 2001. ,
Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity, J. Immunol, vol.166, pp.7096-7103, 2001. ,
A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist, Proc. Natl. Acad. Sci. U.S.A, vol.98, pp.9511-9516, 2001. ,
Comparison of interleukin-22 and interleukin-10 soluble receptor complexes, J. Interferon Cytokine Res, vol.22, pp.1099-1112, 2002. ,
IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease, J. Immunol, vol.178, pp.5973-5981, 2007. ,
Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22, FEBS Lett, vol.583, pp.1072-1077, 2009. ,
Dendritic cells and the control of immunity, Nature, vol.392, pp.245-252, 1998. ,
Steady-state and inflammatory dendritic-cell development, Nat. Rev. Immunol, vol.7, pp.19-30, 2007. ,
Intrinsic and cooperative antigen-presenting functions of dendriticcell subsets in vivo, Nat. Rev. Immunol, vol.7, pp.543-555, 2007. ,
Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart, Genes Immun, vol.5, pp.330-336, 2004. ,
Exonization of the LTR transposable elements in human genome, BMC Genomics, vol.8, p.291, 2007. ,
A subset of cytolytic dendritic cells in rat, J. Immunol, vol.165, pp.4202-4208, 2000. ,
Immunobiology of dendritic cells in the rat, Immunol. Rev, vol.184, pp.58-68, 2001. ,
Isolation of rat intestinal lymph DC, Methods Mol. Biol, vol.595, pp.281-297, 2010. ,
Collection of lymph-borne dendritic cells in the rat, Nat Protoc, vol.1, pp.2263-2270, 2006. ,
Subsets of migrating intestinal dendritic cells, Immunol. Rev, vol.234, pp.259-267, 2010. ,
Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells, Gut, vol.58, pp.1481-1489, 2009. ,
PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells, J. Exp. Med, vol.203, pp.2351-2362, 2006. ,
Retinoic acid production by intestinal dendritic cells, Vitam. Horm, vol.86, pp.127-152, 2011. ,
Prostaglandin E2 suppresses the differentiation of retinoic acidproducing dendritic cells in mice and humans, J. Exp. Med, vol.208, pp.761-773, 2011. ,
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine, Nature, vol.491, pp.259-263, 2012. ,
Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis, Infect. Immun, vol.75, pp.1690-1697, 2007. ,
Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections, J. Immunol, vol.184, pp.4378-4390, 2010. ,
Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation, Immunity, vol.27, pp.610-624, 2007. ,
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting, Annu. Rev. Immunol, vol.31, pp.563-604, 2013. ,
Interleukin 22 signaling promotes cell growth in mantle cell lymphoma, Transl Oncol, vol.4, pp.9-19, 2011. ,
A novel role for IL-22R1 as a driver of inflammation, Blood, vol.117, pp.575-584, 2011. ,
Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans, J. Exp. Med, vol.205, pp.2139-2149, 2008. ,
Intestinal CD103+ dendritic cells: master regulators of tolerance?, Trends Immunol, vol.32, pp.412-419, 2011. ,
How vitamin A metabolizing dendritic cells are generated in the gut mucosa, Trends Immunol, 2011. ,
ROR?t(+) innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota, Nat. Immunol, vol.12, pp.320-326, 2011. ,
Development and evolution of ROR?t(+) cells in a microbe's world, Immunol. Rev, vol.245, pp.177-188, 2012. ,
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense, Immunity, vol.36, pp.276-287, 2012. ,
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5, Nat. Immunol, vol.9, pp.769-776, 2008. ,
All-trans retinoic acid induces TLR-5 expression and cell differentiation and promotes flagellin-mediated cell functions in human THP-1 cells, Immunol. Lett, vol.136, pp.97-107, 2011. ,
Interleukin-22 drives endogenous thymic regeneration in mice, Science, vol.336, pp.91-95, 2012. ,
IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration, Am. J. Physiol. Gastrointest. Liver Physiol, vol.290, pp.827-838, 2006. ,
Constitutive Expression of TNF-Related Activation-Induced Cytokine (TRANCE)/Receptor Activating NF-?B Ligand (RANK)-L by Rat Plasmacytoid Dendritic Cells, PLoS ONE, vol.7, p.33713, 2012. ,
Rat plasmacytoid dendritic cells are an abundant subset of MHC class II+ CD4+CD11b-OX62-and type I IFN-producing cells that exhibit selective expression of Toll-like receptors 7 and 9 and strong responsiveness to CpG, J. Immunol, vol.172, pp.7485-7494, 2004. ,
, Bars represent mean ± SEM of IL-22BP gene to HPRT, expression as determined by the 2 ???Ct method of relative quantification (n=3). * p<0, CD172 high ilDCs, p.5