S. Bahram, N. Mizuki, H. Inoko, and T. Spies, Nucleotide sequence of the human MHC class I MICA gene, Immunogenetics, vol.44, pp.80-81, 1996.

V. Groh, R. Rhinehart, H. Secrist, S. Bauer, K. H. Grabstein et al., Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB, Proc Natl Acad Sci U S A, vol.96, pp.6879-6884, 1999.

S. Bauer, V. Groh, J. Wu, A. Steinle, J. H. Phillips et al., Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA, Science, vol.285, pp.727-729, 1999.

L. Ehrlich, K. Ogasawara, J. A. Hamerman, R. Takaki, A. Zingoni et al., Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells, J Immunol, vol.174, pp.1922-1931, 2005.

N. W. Zwirner, M. A. Fernández-viña, and P. Stastny, MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes, Immunogenetics, vol.47, pp.139-148, 1998.

S. Gasser, S. Orsulic, E. J. Brown, and D. H. Raulet, The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor, Nature, vol.436, pp.1186-1190, 2005.

V. Groh, J. Wu, C. Yee, and T. Spies, Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation, Nature, vol.419, pp.734-738, 2002.

V. Groh, A. Bruhl, H. El-gabalawy, J. L. Nelson, and T. Spies, Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis, Proc Natl Acad Sci U S A, vol.100, pp.9452-9457, 2003.

N. Fodil, L. Laloux, V. Wanner, P. Pellet, G. Hauptmann et al., Allelic repertoire of the human MHC class I MICA gene, Immunogenetics, vol.44, pp.351-357, 1996.

H. A. Stephens, can the enigma of their polymorphism be resolved?, Trends Immunol, vol.22, pp.378-385, 2001.

N. Mizuki, M. Ota, M. Kimura, S. Ohno, H. Ando et al., Triplet repeat polymorphism in the transmembrane region of the MICA gene: A strong association of six GCT repetitions with Behçet disease, Proc Natl Acad Sci U S A, vol.94, pp.1298-1303, 1997.

K. Goto, M. Ota, S. Ohno, N. Mizuki, H. Ando et al., MICA gene and ankylosing spondylitis: Linkage analysis via a transmembrane-encoded triplet repeat polymorphism, Tissue Antigens, vol.49, pp.503-507, 1997.

H. Suemizu, M. Radosavljevic, M. Kimura, S. Sadahiro, S. Yoshimura et al., A basolateral sorting motif in the MICA cytoplasmic tail, Proc Natl Acad Sci U S A, vol.99, pp.2971-2976, 2002.

N. W. Zwirner, C. Y. Marcos, F. Mirbaha, Y. Zou, and P. Stastny, Identification of MICA as a new polymorphic alloantigen recognized by antibodies in sera of organ transplant recipients, Hum Immunol, vol.61, pp.917-924, 2000.

S. Sumitran-holgersson, H. E. Wilczek, J. Holgersson, and K. Söderström, Identification of the nonclassical HLA molecules, mica, as targets for humoral immunity associated with irreversible rejection of kidney allografts, Transplantation, vol.74, pp.268-277, 2002.

K. Mizutani, P. Terasaki, J. D. Bignon, M. Hourmant, A. Cesbron-gautier et al., Association of kidney transplant failure and antibodies against MICA, Hum Immunol, vol.67, pp.683-691, 2006.

Y. Zou, P. Stastny, C. Süsal, B. Döhler, and G. Opelz, Antibodies against MICA antigens and kidney-transplant rejection, N Engl J Med, vol.357, pp.1293-1300, 2007.

K. G. Hankey, C. B. Drachenberg, J. C. Papadimitriou, D. K. Klassen, B. Philosophe et al., MIC expression in renal and pancreatic allografts, vol.73, pp.304-306, 2002.

B. Suárez-alvarez, A. López-vázquez, M. Z. Gonzalez, J. L. Fdez-morera, B. Díaz-molina et al., The relationship of anti-MICA antibodies and MICA expression with heart allograft rejection, Am J Transplant, vol.7, pp.1842-1848, 2007.

P. I. Terasaki, M. Ozawa, and R. Castro, Four-year follow-up of a prospective trial of HLA and MICA antibodies on kidney graft survival, Am J Transplant, vol.7, pp.408-415, 2007.

P. Tonnerre, N. Gérard, M. Chatelais, and B. Charreau, MICA gene polymorphism in kidney allografts and possible impact of functionally relevant variants, Transplant Proc, vol.42, pp.4318-4321, 2010.

S. Bahram, H. Inoko, and T. Shiina, Radosavljevic M: MIC and other NKG2D ligands: From none to too many, Curr Opin Immunol, vol.17, pp.505-509, 2005.

O. Ashiru, P. Boutet, L. Fernández-messina, S. Agüera-gonzález, J. N. Skepper et al., Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes, Cancer Res, vol.70, pp.481-489, 2010.

N. Stern-ginossar and O. Mandelboim, An integrated view of the regulation of NKG2D ligands, Immunology, vol.128, pp.1-6, 2009.

S. Chatterjee and J. K. Pal, Role of 59-and 39-untranslated regions of mRNAs in human diseases, Biol Cell, vol.101, pp.251-262, 2009.

E. Canet, J. Devallière, N. Gérard, G. Karam, M. Giral et al., Profiling posttransplant circulating antibodies in kidney transplantation using donor endothelial cells, Transplantation, vol.93, pp.257-264, 2012.

E. W. Petersdorf, K. B. Shuler, G. M. Longton, T. Spies, and J. A. Hansen, Population study of allelic diversity in the human MHC class I-related MIC-A gene, Immunogenetics, vol.49, pp.605-612, 1999.

Y. Zhang, A. M. Lazaro, B. Lavingia, and P. Stastny, Typing for all known MICA alleles by group-specific PCR and SSOP, Hum Immunol, vol.62, pp.620-631, 2001.

S. Shafi, P. Vantourout, G. Wallace, A. Antoun, R. Vaughan et al., An NKG2D-mediated human lymphoid stress surveillance response with high interindividual variation, Sci Transl Med, vol.3, pp.113-124, 2011.

D. Lin, H. Lavender, E. J. Soilleux, O. 'callaghan, and C. A. , NF-kB regulates MICA gene transcription in endothelial cell through a genetically inhibitable control site, J Biol Chem, vol.287, pp.4299-4310, 2012.

L. Coscoy, D. J. Sanchez, and D. Ganem, A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition, J Cell Biol, vol.155, pp.1265-1273, 2001.

M. Thomas, J. M. Boname, S. Field, S. Nejentsev, M. Salio et al., Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity, Proc Natl Acad Sci U S A, vol.105, pp.1656-1661, 2008.

L. G. Hidalgo, P. M. Campbell, B. Sis, G. Einecke, M. Mengel et al., De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure, Am J Transplant, vol.9, pp.2532-2541, 2009.

L. G. Hidalgo, B. Sis, J. Sellares, P. M. Campbell, M. Mengel et al., NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: Evidence for NK cell involvement in antibody-mediated rejection, Am J Transplant, vol.10, pp.1812-1822, 2010.

D. Todorova, F. Sabatier, D. E. Lyonnet, L. Vacher-coponat, H. Robert et al., Fractalkine expression induces endothelial progenitor cell lysis by natural killer cells, PLoS ONE, vol.6, p.26663, 2011.

H. R. Salih, H. Rammensee, and A. Steinle, Cutting edge: Down-regulation of MICA on human tumors by proteolytic shedding, J Immunol, vol.169, pp.4098-4102, 2002.

B. Suárez-alvarez, A. López-vázquez, B. Díaz-molina, M. J. Bernardorodríguez, R. Alvarez-lópez et al., The predictive value of soluble major histocompatibility complex class I chain-related molecule A (MICA) levels on heart allograft rejection, Transplantation, vol.82, pp.354-361, 2006.

A. Clayton and Z. Tabi, Exosomes and the MICA-NKG2D system in cancer, Blood Cells Mol Dis, vol.34, pp.206-213, 2005.

L. Alvarez-erviti, Y. Seow, H. Yin, C. Betts, S. Lakhal et al., Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes, Nat Biotechnol, vol.29, pp.341-345, 2011.

S. Agüera-gonzález, C. C. Gross, L. Fernández-messina, O. Ashiru, G. Esteso et al., Valés-Gómez M: Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding, Eur J Immunol, vol.41, pp.3667-3676, 2011.

C. Théry, M. Ostrowski, and E. Segura, Membrane vesicles as conveyors of immune responses, Nat Rev Immunol, vol.9, pp.581-593, 2009.

K. Mizutani, P. Terasaki, A. Rosen, V. Esquenazi, J. Miller et al., Serial ten-year follow-up of HLA and MICA antibody production prior to kidney graft failure, Am J Transplant, vol.5, pp.2265-2272, 2005.

Q. Zhang, J. M. Cecka, D. W. Gjertson, P. Ge, M. L. Rose et al., HLA and MICA: Targets of antibody-mediated rejection in heart transplantation, Transplantation, vol.91, pp.1153-1158, 2011.

Y. Zou, Z. Qin, A. Silveus, Y. Fan, and P. Stastny, Polymorphisms of MICA recognized by human alloantibodies, Immunogenetics, vol.61, pp.91-100, 2009.

S. Coupel, F. Leboeuf, G. Boulday, J. Soulillou, and B. Charreau, RhoA activation mediates phosphatidylinositol 3-kinase-dependent proliferation of human vascular endothelial cells: An alloimmune mechanism of chronic allograft nephropathy, J Am Soc Nephrol, vol.15, pp.2429-2439, 2004.

Y. Katsuyama, M. Ota, H. Ando, S. Saito, N. Mizuki et al., Sequencing based typing for genetic polymorphisms in exons, 2, 3 and 4 of the MICA gene, Tissue Antigens, vol.54, pp.178-184, 1999.

K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method, Methods, vol.25, pp.402-408, 2001.

S. Coupel, A. Moreau, M. Hamidou, V. Horejsi, J. Soulillou et al., Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation, Blood, vol.109, pp.2806-2814, 2007.

Z. Li, V. Groh, and R. K. Strong, Spies T: A single amino acid substitution causes loss of expression of a MICA allele, Immunogenetics, vol.51, pp.246-248, 2000.

N. Kotecha, P. O. Krutzik, and J. M. Irish, Web-based analysis and publication of flow cytometry experiments, Curr Protoc Cytom Chapter, vol.10, 2010.