, 59 (s, 1H, NHBoc), 7.30 (d, J = 8.4 Hz, 2H, CH Ar PhNHBoc), 7.25 (s, 1H, CH Ar pico), 7.15 (d, J = 8.4 Hz, 2H, CH Ar PhNHBoc), 3.91 (s, 3H, CH 3 pico), 3.82 (d, J = 14.6 Hz, 1H, CH 2 pico), 3.68 (d, J = 14.6 Hz, 1H, CH 2 pico) 3H), pp.58-60
, ESI-HRMS ( positive) m/z calcd for [C 45 H 71 N 6 O 10 ] + , 855.5226; found 855 Compound 8: p-NH 2 -Bn-TE1PA Compound 7 (183 mg, 0.214 mmol) was dissolved in hydrochloric acid (3 M, 15 mL) and the solution was refluxed for 18 h. The water and excess of hydrochloric acid were evaporated under reduced pressure. The crude product was purified using reverse phase C18 HPLC (H 2 O/CH 3 CN from 0 to 80% CH 3 CN) to give compound 8 as a colorless oil (41 mg, 35%) in its hydrochloride salt, pp.522681-522688
, 76 ?L, 0.987 mmol, 20 eq.) in 1 mL of chloroform . The reaction mixture was vigorously stirred overnight at RT. The excess of thiophosgene was removed and the aqueous phase was washed with chloroform (3 × 1 mL) The aqueous phase was lyophilized to give compound 9 as a white powder (19 mg, 65%) in its hydrochloride salt (estimation x = 3)27 (s, 4H, CH Ar PhNCS), 4.08 (d, J = 14, TE1PA Compound 8 (27 mg, 0.049 mmol) was dissolved in hydrochloric acid (1 mL H NMR (500 MHz, D 2 O, 25 °C) ? 8.14 (d, J = 7.1 Hz, 1H, CH Ar pico), 8.01 (t, J = 7.1 Hz, 1H CH Ar pico) 12H, CH 2 -?-N), 2.87?2.55 (m, 6H; CH 2 -?-N; CH 2 ?PhNCS), 2.28 (s, 1H)CO), [160.4, pp.6142-6144
, ANR) within the program Investissements d'Avenir " . We also thank the Plateau Technique de Radioactivité " and the animal housing of the, IRS-UN " . Notes and references Acc. Chem. Res. J. Clin. Oncol, vol.1, issue.26, pp.832-841, 2008.
, Monopicolinate Cyclen and Cyclam Derivatives for Stable Copper(II) Complexation, Inorganic Chemistry, vol.51, issue.12, pp.6916-6927, 2012.
DOI : 10.1021/ic300784v
URL : https://hal.archives-ouvertes.fr/hal-01557438
, license number: C44278/imaging reference: 00143, Phys. Med. Phys. Med. Biol, vol.23, issue.3079, pp.849-853, 2009.