International Consensus (ICON): allergic reactions to vaccines

Stephen C. Dreskin (1) , Neal A. Halsey (2) , John M. Kelso (3) , Robert A. Wood (4) , Donna S. Hummell (5) , Kathryn M. Edwards (6) , Jean-Christoph Caubet (7) , Renata J. M. Engler (8) , Michael S. Gold (9) , Claude Ponvert (10) , Pascal Demoly (11, 12, 13) , Mario Sanchez-Borges (14) , Antonella Muraro (15) , James T. Li (16) , Menachem Rottem (17) , Lanny J. Rosenwasser (18)

1 Division of Allergy and Clinical Immunology [Aurora, CO, USA]
2 Department of International Health [Baltimore, MD, USA]
3 Division of Allergy, Asthma, and Immunology [San Diego, CA, USA]
4 The Division of Pediatric Allergy and Immunology [Baltimore, USA]
5 Division of Pediatric Allergy, Immunology, and Pulmonary Medicine [Nashville, TN, USA]
6 Division of Pediatric Infectious Diseases [Nashville, TN, USA]
7 Department of Pediatrics [Geneva, Switzerland]
8 Allergy-Immunology-Immunization - Department of Medicine and Pediatrics [Bethesda, MD, USA]
9 Disipline of Paediatrics [Adelaide SA, Australia]
10 Service de Pneumologie Allergologie [CHU Necker]
11 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
12 SU - Sorbonne Université
13 Département pneumologie et addictologie [Montpellier]
14 Department of Allergy and Clinical Immunology [Caracas, Venezuela]
15 Food Allergy Referral Centre Veneto Region [Padua, Italy]
16 Division of Allergic Diseases [Rochester, MN, USA]
17 Allergy Asthma and Immunology [Haifa, Israel]
18 Allergy-Immunology Division [Kansas City, MO, USA]

Background: Routine immunization, one of the most effective public health interventions, has effectively reduced death and morbidity due to a variety of infectious diseases. However, allergic reactions to vaccines occur very rarely and can be life threatening. Given the large numbers of vaccines administered worldwide, there is a need for an international consensus regarding the evaluation and management of allergic reactions to vaccines. Methods: Following a review of the literature, and with the active participation of representatives from the World Allergy Organization (WAO), the European Academy of Allergy and Clinical Immunology (EAACI), the American Academy of Allergy, Asthma, and Immunology (AAAAI), and the American College of Allergy, Asthma, and Immunology (ACAAI), the final committee was formed with the purpose of having members who represented a wide-range of countries, had previously worked on vaccine safety, and included both allergist/ immunologists as well as vaccinologists. Results: Consensus was reached on a variety of topics, including: definition of immediate allergic reactions, including anaphylaxis, approaches to distinguish association from causality, approaches to patients with a history of an allergic reaction to a previous vaccine, and approaches to patients with a history of an allergic reaction to components of vaccines. Conclusions: This document provides comprehensive and internationally accepted guidelines and access to on-line documents to help practitioners around the world identify allergic reactions following immunization. It also provides a framework for the evaluation and further management of patients who present either following an allergic reaction to a vaccine or with a history of allergy to a component of vaccines.

Mots clés: Allergic reactions; Allergy; Consensus; International; Vaccine; Anaphylaxis; Components; Causality

Domaines: Sciences du Vivant [q-bio]

Stephen C. Dreskin, Neal A. Halsey, John M. Kelso, Robert A. Wood, Donna S. Hummell, et al.. International Consensus (ICON): allergic reactions to vaccines. World Allergy Organization Journal, 2015, 9 (1), pp.32. ⟨10.1186/s40413-016-0120-5⟩. ⟨inserm-01367834⟩