Early objective response may not be a prognostic factor of survival for patients with metastatic urothelial carcinoma: from a retrospective analysis of a cohort of 113 patients - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Negative Results in BioMedicine Année : 2015

Early objective response may not be a prognostic factor of survival for patients with metastatic urothelial carcinoma: from a retrospective analysis of a cohort of 113 patients

Résumé

Background: This study aims to better define prognostic factors for patients with metastatic urothelial carcinoma (mUC), and to identify patients who will benefit from first-line cisplatin-based chemotherapy. We test the hypothesis that early objective response (EOR), defined as the occurrence of an objective response following 2 or 3 courses of chemotherapy, could be a prognostic factor for overall survival (OS) and thus be used to guide treatment decisions. Data from 113 patients with evaluable mUC receiving first-line cisplatin-based treatment between January 2004 and December 2006 was collected retrospectively from prospectively-maintained databases across seven French cancer centers. Clinical factors potentially associated with survival and EOR were analyzed in univariate and multivariate analysis. Results: One hundred three patient records were complete and available for inclusion in the multivariate model. Four factors were independently associated with OS: Performance status 1 and 2 (HR 2.3 [95 % CI 1.3–3.9], p = 0.002; HR 3.4 [95 % CI 1.6–7.2], p = 0.001 respectively); presence of visceral metastases (HR 2.2 [95 % CI 1.3–3.9], p = 0.004); abnormal hemoglobin levels (HR 1.7 [95 % CI 1.01–2.8], p = 0.045); disease progression (HR 10.1 [95 % CI 4.2–24.1], p < 0.001).
Fichier principal
Vignette du fichier
art%3A10.1186%2Fs12952-015-0037-5.pdf (521.73 Ko) Télécharger le fichier
12952_2015_Article_37.pdf (521.73 Ko) Télécharger le fichier
Origine : Publication financée par une institution
Origine : Publication financée par une institution
Loading...

Dates et versions

inserm-01264496 , version 1 (29-01-2016)

Identifiants

Citer

Guilhem Roubaud, Véronique Brouste, Phillipe Beuzeboc, Aude Fléchon, Diego Tosi, et al.. Early objective response may not be a prognostic factor of survival for patients with metastatic urothelial carcinoma: from a retrospective analysis of a cohort of 113 patients. Journal of Negative Results in BioMedicine, 2015, 14 (1), pp.18. ⟨10.1186/s12952-015-0037-5⟩. ⟨inserm-01264496⟩
154 Consultations
194 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More