Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis.

Abstract : Numerous epidemiological studies and clinical trials have reported the health benefits of omega-3 polyunsaturated fatty acids (PUFA), including a lower risk of coronary heart diseases. This review mainly focuses on the effects of alpha-linolenic (ALA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids on some risk factors associated with atherothrombosis, including platelet activation, plasma lipid concentrations and oxidative modification of low-density lipoproteins (LDL). Special focus is given to the effects of marine PUFA on the formation of eicosanoids and docosanoids, and to the bioactive properties of some oxygenated metabolites of omega-3 PUFA produced by cyclooxygenases and lipoxygenases. The antioxidant effects of marine omega-3 PUFA at low concentrations and the pro-oxidant effects of DHA at high concentrations on the redox status of platelets and LDL are highlighted. Non enzymatic peroxidation end-products deriving from omega-3 PUFA such as hydroxy-hexenals, neuroketals and EPA-derived isoprostanes are also considered in relation to atherosclerosis.
Document type :
Journal articles
Complete list of metadatas

Cited literature [127 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01072309
Contributor : Evelyne Vericel <>
Submitted on : Wednesday, October 8, 2014 - 9:19:11 AM
Last modification on : Monday, March 11, 2019 - 4:18:07 PM
Long-term archiving on : Friday, January 9, 2015 - 10:31:33 AM

File

Guichardant et al BBA.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Michel Guichardant, Catherine Calzada, Nathalie Bernoud-Hubac, Michel Lagarde, Evelyne Véricel. Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis.. BBA - Biochimica et Biophysica Acta, Elsevier, 2014, epub ahead of print. ⟨10.1016/j.bbalip.2014.09.013⟩. ⟨inserm-01072309⟩

Share

Metrics

Record views

303

Files downloads

533