Incidence and Risk Factors for Follow-Up Interruption of HIV-Infected Patients in Guadeloupe

Narcisse Elenga (1) , Marie-Thérèse Georger-Sow (2) , Thierry Messiaen (3) , Isabelle Lamaurie (3) , Isabelle Favre (3) , Mathieu Nacher (4) , Gilles Beaucaire (3)

1 EA 3593 Université des Antilles et de la Guyane
2 COREVIH - Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine [Pointe-à-Pitre]
3 Service des maladies infectieuses
4 EA 3593 Université des Antilles et de la Guyane

Background: Guadeloupe is the region of France with the second highest prevalence of HIV. Methods: To determine the risk factors for being lost to follow-up (LFU), a retrospective cohort study of 2,732 patients followed between 1988 and 2009 was conducted, and determined which variables were related to being LFU, i.e. permanently disappearing from HIV clinics or coming back after more than one year of missed appointments. Results: The incidence rate for permanent follow-up interruption was 9 per 100 person-years (8.3-9.7 personyears). The median time of LFU was 6.4 years (interquartile range 3-16.9 years). Cox modelling showed that the younger age groups (HR: 1.60[1.30-2.10], p=0.000) and patients diagnosed before 1997 (HR: 4.80[3.50-6.50], p=0.000) were significantly more likely to be permanently LFU. However, patients treated with HAART had a lower risk of being LFU (HR: 0.63[0.51-0.80], p=0.000). Conclusion: These results suggest that some patients may have died. They also allow to quantify the magnitude of a major yet often under-recognized problem and to identify its predictors in the context of Guadeloupe. This could help clinicians improve patient retention.

Mots clés: HIV-infected patients; Follow-up interruption; Risk factors; Guadeloupe

Domaines: Santé publique et épidémiologie

Narcisse Elenga, Marie-Thérèse Georger-Sow, Thierry Messiaen, Isabelle Lamaurie, Isabelle Favre, et al.. Incidence and Risk Factors for Follow-Up Interruption of HIV-Infected Patients in Guadeloupe. J AIDS Clin Res, 2013, 4 (9), pp.1000238. ⟨10.4172/2155-6113.1000238⟩. ⟨inserm-00915235⟩