The road to clinical use of high-intensity focused ultrasound for liver cancer: technical and clinical consensus

Jean-Francois Aubry (1, 2) , Kim Butts Pauly (3) , Chrit Moonen (4) , Gail Ter Haar (5) , Mario Ries (4) , Rares Salomir (6) , Sham Sokka (7) , Kevin Michael Sekins (8) , Yerucham Shapira (9) , Fangwei Ye (10) , Heather Huff-Simonin (11) , Matt Eames (11) , Arik Hananel (11) , Neal Kassell (11) , Alessandro Napoli (12) , Joo Ha Hwang (13) , Feng Wu (14) , Lian Zhang (15) , Andreas Melzer (16) , Young-Sun Kim (17) , Wladyslaw Gedroyc (18, 19)

1 Department of Radiation Oncology
2 IL - Institut Langevin - Ondes et Images (UMR7587)
3 RSL - Radiological Sciences Laboratory [Stanford]
4 Imaging Division
5 Division of Radiotherapy and Imaging
6 Faculty of Medicine
7 Philips Healthcare
8 Ultrasound Innovations Applications
9 InSightec Ltd
10 Chongqing Haifu Medical Technology Co.
11 Focused Ultrasound Foundation
12 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
13 Digestive Disease Center
14 Institute of Ultrasonic Engineering in Medicine
15 Clinical Center for Tumor Therapy
16 Institute for Medical Science and Technology
17 Department of Radiology
18 Department of Medicine
19 Saint Mary's Hospital [London]

Clinical use of high-intensity focused ultrasound (HIFU) under ultrasound or MR guidance as a non-invasive method for treating tumors is rapidly increasing. Tens of thousands of patients have been treated for uterine fibroid, benign prostate hyperplasia, bone metastases, or prostate cancer. Despite the methods' clinical potential, the liver is a particularly challenging organ for HIFU treatment due to the combined effect of respiratory-induced liver motion, partial blocking by the rib cage, and high perfusion/flow. Several technical and clinical solutions have been developed by various groups during the past 15 years to compensate for these problems. A review of current unmet clinical needs is given here, as well as a consensus from a panel of experts about technical and clinical requirements for upcoming pilot and pivotal studies in order to accelerate the development and adoption of focused ultrasound for the treatment of primary and secondary liver cancer.

Mots clés: Ultrasound; Non-invasive surgery; High-intensity ultrasound; Focused ultrasound; Liver cancer

Domaines: Cancer

Jean-Francois Aubry, Kim Butts Pauly, Chrit Moonen, Gail Ter Haar, Mario Ries, et al.. The road to clinical use of high-intensity focused ultrasound for liver cancer: technical and clinical consensus. Journal of Therapeutic Ultrasound, 2013, 1 (1), pp.13. ⟨inserm-00851863⟩