Cannabis use, ischemic stroke, and multifocal intracranial vasoconstriction: a prospective study in 48 consecutive young patients.

Valérie Wolff (1) , Valérie Lauer (1) , Olivier Rouyer (2) , François Sellal (3) , Nicolas Meyer (4) , Jean Sébastien Raul (5) , Cécile Sabourdy (6) , Fazel Boujan (7) , Christine Jahn (7) , Rémy Beaujeux (7) , Christian Marescaux (1)

1 Unité Neuro-vasculaire
2 MSP - Mitochondrie, Stress oxydant et Protection musculaire
3 Service de neurologie
4 Laboratoire de biostatistique
5 Laboratoire de Toxicologie
6 ANTE-INSERM U836, équipe 9, Dynamique des réseaux synchrones épileptiques
7 Service de radiologie [Strasbourg]

BACKGROUND AND PURPOSE: Our objective was to evaluate the relationship between cannabis use and ischemic stroke in a young adult population. METHODS: Forty-eight consecutive young patients admitted for acute ischemic stroke participated in the study. First-line screening was performed, including blood tests, cardiovascular investigations, and urine analysis for cannabinoids. If no etiology was found, 3D rotational angiography and cerebrospinal fluid analysis were performed. A control was planned through neurovascular imaging within 3 to 6 months. RESULTS: In this series, there was multifocal intracranial stenosis associated with cannabis use in 21% (n=10). CONCLUSIONS: Multifocal angiopathy associated with cannabis consumption could be an important cause of ischemic stroke in young people.

Mots clés: stroke in young adults; vasospasm; cannabis

Domaines: Neurosciences [q-bio.NC]; Cardiologie et système cardiovasculaire

Valérie Wolff, Valérie Lauer, Olivier Rouyer, François Sellal, Nicolas Meyer, et al.. Cannabis use, ischemic stroke, and multifocal intracranial vasoconstriction: a prospective study in 48 consecutive young patients.: Ischemic Stroke and Cannabis. Stroke, 2011, 42 (6), pp.1778-80. ⟨10.1161/STROKEAHA.110.610915⟩. ⟨inserm-00676840⟩