M. Klein, S. Kenan, and M. Lewis, Osteosarcoma, American Journal of Clinical Pathology, vol.125, issue.4, pp.327-345, 1989.
DOI : 10.1309/UC6KQHLD9LV2KENN

S. Weiss and J. Goldblum, Enzinger and Weiss' Soft Tissue Tumors, 2001.

H. Tsuchiya, Y. Kanazawa, and M. Wanis, Effect of Timing of Pulmonary Metastases Identification on Prognosis of Patients With Osteosarcoma: The Japanese Musculoskeletal Oncology Group Study, Journal of Clinical Oncology, vol.20, issue.16, pp.3470-3477, 2002.
DOI : 10.1200/JCO.2002.11.028

S. Theoleyre, Y. Wittrant, K. Tat, S. Fortun, Y. Rédini et al., The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling, Cytokine & Growth Factor Reviews, vol.15, issue.6, pp.457-475, 2004.
DOI : 10.1016/j.cytogfr.2004.06.004

E. Grimaud, L. Soubigou, and S. Couillaud, Receptor Activator of Nuclear Factor ??B Ligand (RANKL)/Osteoprotegerin (OPG) Ratio Is Increased in Severe Osteolysis, The American Journal of Pathology, vol.163, issue.5, pp.2021-2031, 2003.
DOI : 10.1016/S0002-9440(10)63560-2

L. Huang, Y. Cheng, L. Chow, M. Zheng, and S. Kumta, Tumour cells produce receptor activator of NF-kappaB ligand (RANKL) in skeletal metastases, Journal of Clinical Pathology, vol.55, issue.11, pp.877-878, 2002.
DOI : 10.1136/jcp.55.11.877

R. Thomas, T. Guise, and J. Yin, Breast Cancer Cells Interact with Osteoblasts to Support Osteoclast Formation, Endocrinology, vol.140, issue.10, pp.4451-4458, 1999.
DOI : 10.1210/en.140.10.4451

J. Chirgwin and T. Guise, Molecular mechanisms of tumorbone interactions in osteolytic metastases, Crit Rev Eukaryot Gene Expr, vol.10, pp.159-178, 2000.

T. Narita, N. Kawakami-kimura, and M. Sato, Alteration of Integrins by Heparin-Binding EGF Like Growth Factor in Human Breast Cancer Cells, Oncology, vol.53, issue.5, pp.374-381, 1996.
DOI : 10.1159/000227591

A. Kamijo, T. Koshino, M. Uesugi, H. Nitto, and T. Saito, Inhibition of lung metastasis of osteosarcoma cell line POS-1 transplanted into mice by thigh ligation, Cancer Letters, vol.188, issue.1-2, pp.213-219, 2002.
DOI : 10.1016/S0304-3835(02)00433-0

Y. Wittrant, S. Theoleyre, S. Couillaud, C. Dunstan, D. Heymann et al., Relevance of an in vitro osteoclastogenesis system to study receptor activator of NF-kB ligand and osteoprotegerin biological activities, Experimental Cell Research, vol.293, issue.2, pp.292-301, 2004.
DOI : 10.1016/j.yexcr.2003.10.016

C. Chipoy, M. Berreur, and S. Couillaud, Downregulation of Osteoblast Markers and Induction of the Glial Fibrillary Acidic Protein by Oncostatin M in Osteosarcoma Cells Require PKC?? and STAT3, Journal of Bone and Mineral Research, vol.100, issue.Suppl, pp.1850-1861, 2004.
DOI : 10.1359/JBMR.040817

Z. Lee and H. Kim, Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts, Biochemical and Biophysical Research Communications, vol.305, issue.2, pp.211-214, 2003.
DOI : 10.1016/S0006-291X(03)00695-8

E. Hay, J. Lemonnier, O. Fromigue, and M. Pj, Bone Morphogenetic Protein-2 Promotes Osteoblast Apoptosis through a Smad-independent, Protein Kinase C-dependent Signaling Pathway, Journal of Biological Chemistry, vol.276, issue.31, pp.29028-29036, 2001.
DOI : 10.1074/jbc.M011265200

H. Yoshikawa, M. Ohishi, S. Kohriki, M. Yoshiura, and Y. Ohsaki, Establishment and characterisation of an osteoblastic clonal cell line from human mandibular osteosarcoma (HMOS-1), Oral Oncology, vol.33, issue.3, pp.163-168, 1997.
DOI : 10.1016/S0964-1955(96)00075-9

P. Ducy, R. Zhang, V. Geoffroy, A. Ridall, and G. Karsenty, Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation, Cell, vol.89, issue.5, pp.747-754, 1997.
DOI : 10.1016/S0092-8674(00)80257-3

J. Delaissé, T. Andersen, M. Engsig, K. Henriksen, T. Troen et al., Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities, Microscopy Research and Technique, vol.97, issue.6, pp.504-513, 2003.
DOI : 10.1002/jemt.10374

R. Masuda, H. Sakiyama, and T. Nonaka, Establishment and characterization of tartrate-resistant acid phosphatase and alkaline phosphatase double positive cell lines, Cell and Tissue Research, vol.304, issue.3, pp.351-359, 2001.
DOI : 10.1007/s004410100347

O. Olstad, V. Gautvik, and S. Reppe, Molecular heterogeneity in human osteosarcoma demonstrated by enriched mRNAs isolated by directional tag PCR subtraction cloning, Anticancer Res, vol.23, pp.2201-2216, 2003.

N. Miyamoto, Y. Higuchi, and K. Mori, Human osteosarcoma-derived cell lines produce soluble factor(s) that induces differentiation of blood monocytes to osteoclast-like cells, International Immunopharmacology, vol.2, issue.1, pp.25-38, 2002.
DOI : 10.1016/S1567-5769(01)00134-5

L. Rifas, S. Arackal, M. Weitzmann, W. Kafienah, D. Bromme et al., Inflammatory T cells rapidly induce differentiation of human bone marrow stromal cells into mature osteoblasts, Journal of Cellular Biochemistry, vol.95, issue.4, pp.650-659, 1998.
DOI : 10.1002/jcb.10436

L. Evans, A. Bilbe, G. Bowler, and W. , The osteoclastassociated protease cathepsin K is expressed in human breast carcinoma, Cancer Res, vol.57, pp.5386-5390, 1997.

K. Brubaker, R. Vessella, L. True, R. Thomas, and C. E. , Cathepsin K mRNA and Protein Expression in Prostate Cancer Progression, Journal of Bone and Mineral Research, vol.43, issue.2, pp.222-230, 2003.
DOI : 10.1359/jbmr.2003.18.2.222

P. Croucher, C. Shipman, and J. Lippitt, Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma, Blood, vol.98, issue.13, pp.3534-3540, 2001.
DOI : 10.1182/blood.V98.13.3534

J. Zhang, J. Dai, and Y. Qi, Osteoprotegerin inhibits prostate cancer???induced osteoclastogenesis and prevents prostate tumor growth in the bone, Journal of Clinical Investigation, vol.107, issue.10, pp.1235-1244, 2001.
DOI : 10.1172/JCI11685

T. Michigami, M. Ihara-watanabe, M. Yamazaki, and K. Ozono, Receptor activator of nuclear factor kappaB ligand (RANKL) is a key molecule of osteoclast formation for bone metastasis in a newly developed model of human neuroblastoma, Cancer Res, vol.61, pp.1637-1644, 2001.

H. Hsu, D. Lacey, and C. Dunstan, Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand, Proceedings of the National Academy of Sciences, vol.96, issue.7, pp.3540-3545, 1999.
DOI : 10.1073/pnas.96.7.3540

M. Tometsko, A. Armstrong, and R. Miller, RANK ligand directly induces osteoclastogenic, angiogenic, chemoattractive and invasive factors on RANK-expressing human cancer cells MDA-MB-231 and PC3, J Bone Miner Res, vol.19, p.25, 2004.

C. Kawamura, M. Kizaki, and Y. Ikeda, Bone Morphogenetic Protein (BMP)-2 Induces Apoptosis in Human Myeloma Cells, Leukemia & Lymphoma, vol.94, issue.3, pp.635-639, 2002.
DOI : 10.1016/S1074-7613(00)80011-4

H. Soda, R. E. Sharma, and S. , Antiproliferatiye effects of recombinant human bone morphogenetic protein-2 on human tumor colony-forming units, Anti-Cancer Drugs, vol.9, issue.4, pp.327-331, 1998.
DOI : 10.1097/00001813-199804000-00006

Y. Wittrant, S. Théoleyre, and C. Chipoy, RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1704, issue.2, pp.49-57, 2004.
DOI : 10.1016/j.bbcan.2004.05.002

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