 |
Journal articles
Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage.
Abstract : The introduction of the highly active antiretroviral therapy (HAART) has greatly improved survival. However, these treatments fail to definitively cure the patients and unveil the presence of quiescent HIV-1 reservoirs like cells from monocyte-macrophage lineage. A purge, or at least a significant reduction of these long lived HIV-1 reservoirs will be needed to raise the hope of the viral eradication. This review focuses on the molecular mechanisms responsible for viral persistence in cells of the monocyte-macrophage lineage. Controversy on latency and/or cryptic chronic replication will be specifically evoked. In addition, since HIV-1 infected monocyte-macrophage cells appear to be more resistant to apoptosis, this obstacle to the viral eradication will be discussed. Understanding the intimate mechanisms of HIV-1 persistence is a prerequisite to devise new and original therapies aiming to achieve viral eradication.
Cited literature [180 references]
https://www.hal.inserm.fr/inserm-00663900
Contributor : Ed. Bmc <>
Submitted on : Friday, January 27, 2012 - 5:15:01 PM
Last modification on : Tuesday, October 27, 2020 - 2:34:41 PM
Long-term archiving on: : Saturday, April 28, 2012 - 2:41:53 AM
Contributor : Ed. Bmc <>
Submitted on : Friday, January 27, 2012 - 5:15:01 PM
Last modification on : Tuesday, October 27, 2020 - 2:34:41 PM
Long-term archiving on: : Saturday, April 28, 2012 - 2:41:53 AM