Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol, p.12 ,
Structure, expression and function of a schwannoma-derived growth factor, Nature, vol.348, issue.6298, pp.257-260, 1990. ,
DOI : 10.1038/348257a0
Cell Surface Ectodomain Cleavage of Human Amphiregulin Precursor Is Sensitive to a Metalloprotease Inhibitor. RELEASE OF A PREDOMINANT N-GLYCOSYLATED 43-kDa SOLUBLE FORM, Journal of Biological Chemistry, vol.273, issue.27, pp.273-17258, 1998. ,
DOI : 10.1074/jbc.273.27.17258
Role of ADAMs in Cancer Formation and Progression, Clinical Cancer Research, vol.15, issue.4, pp.1140-1144, 2009. ,
DOI : 10.1158/1078-0432.CCR-08-1585
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development, Development, vol.126, pp.2739-2750, 1999. ,
Structure and function of human amphiregulin: a member of the epidermal growth factor family, Science, vol.243, issue.4894, pp.1074-1076, 1989. ,
DOI : 10.1126/science.2466334
Untangling the ErbB signalling network, Nature Reviews Molecular Cell Biology, vol.2, issue.2, pp.127-137, 2001. ,
DOI : 10.1038/35052073
EGF???ERBB signalling: towards the systems level, Nature Reviews Molecular Cell Biology, vol.96, issue.7, pp.505-516, 2006. ,
DOI : 10.1038/nrm1962
NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer, The EMBO Journal, vol.19, issue.13, pp.3159-3167, 2000. ,
DOI : 10.1093/emboj/19.13.3159
The ErbB receptors and their role in cancer progression, Experimental Cell Research, vol.284, issue.1, pp.99-110, 2003. ,
DOI : 10.1016/S0014-4827(02)00099-X
Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities, J. Biol. Chem, pp.271-6071, 1996. ,
Auto-and cross-induction within the mammalian epidermal growth factor-related peptide family, J. Biol. Chem, pp.269-22817, 1994. ,
Epidermal growth factor receptor (EGFR) signaling in cancer, Gene, vol.366, issue.1, pp.2-16, 2006. ,
DOI : 10.1016/j.gene.2005.10.018
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies, The Journal of Cell Biology, vol.112, issue.5, pp.843-854, 2002. ,
DOI : 10.1074/jbc.274.44.31707
EGF and amphiregulin differentially regulate Cbl recruitment to endosomes and EGF receptor fate, Biochemical Journal, vol.410, issue.3, pp.410-585, 2008. ,
DOI : 10.1042/BJ20071505
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507514
Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop, Cellular Signalling, vol.21, issue.2, pp.212-219, 2009. ,
DOI : 10.1016/j.cellsig.2008.10.003
Autocrine, paracrine and juxtacrine signaling by EGFR ligands, Cellular Signalling, vol.17, issue.10, pp.1183-1193, 2005. ,
DOI : 10.1016/j.cellsig.2005.03.026
The epidermal growth factor receptor ligands at a glance, Journal of Cellular Physiology, vol.282, issue.3, pp.460-466, 2009. ,
DOI : 10.1002/jcp.21635
Heparin inhibition of autonomous growth implicates amphiregulin as an autocrine growth factor for normal human mammary epithelial cells, Journal of Cellular Physiology, vol.48, issue.1, pp.153-103, 1992. ,
DOI : 10.1002/jcp.1041530114
Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin, Development, vol.132, issue.17, pp.3923-3933, 2005. ,
DOI : 10.1242/dev.01966
Autocrine and Juxtacrine Effects of Amphiregulin on the Proliferative, Invasive, and Migratory Properties of Normal and Neoplastic Human Mammary Epithelial Cells, Journal of Biological Chemistry, vol.281, issue.49, pp.281-37728, 2006. ,
DOI : 10.1074/jbc.M606532200
Epidermal Growth Factor Receptor Inhibitors in Neuro-oncology: Hopes and Disappointments, Clinical Cancer Research, vol.14, issue.4, pp.957-960, 2008. ,
DOI : 10.1158/1078-0432.CCR-07-1810
Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts, International Journal of Molecular Medicine, vol.18, pp.497-503, 2006. ,
DOI : 10.3892/ijmm.18.3.497
Amphiregulin: An early trigger of liver regeneration in mice, Gastroenterology, vol.128, issue.2, pp.424-432, 2005. ,
DOI : 10.1053/j.gastro.2004.11.006
TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells, The EMBO Journal, vol.22, issue.10, pp.2411-2421, 2003. ,
DOI : 10.1093/emboj/cdg231
The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity., Molecular and Cellular Biology, vol.10, issue.5, pp.10-1969, 1990. ,
DOI : 10.1128/MCB.10.5.1969
Novel Role for Amphiregulin in Protection from Liver Injury, Journal of Biological Chemistry, vol.280, issue.19, pp.280-19012, 2005. ,
DOI : 10.1074/jbc.M413344200
Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development, Proc. Natl ,
Expression and function of amphiregulin during murine preimplantation development, Mol. Reprod. Dev, pp.47-271, 1997. ,
Amphiregulin Mediates Estrogen, Progesterone, and EGFR Signaling in the Normal Rat Mammary Gland and in Hormone-Dependent Rat Mammary Cancers, Hormones and Cancer, vol.150, issue.Suppl 1, pp.229-244, 2010. ,
DOI : 10.1007/s12672-010-0048-0
Alterations of Gene Expression in the Development of Early Hyperplastic Precursors of Breast Cancer, The American Journal of Pathology, vol.171, issue.1, pp.171-252, 2007. ,
DOI : 10.2353/ajpath.2007.061010
Expression of the epidermal growth factor system in human endometrium during the menstrual cycle, Molecular Human Reproduction, vol.11, issue.8, pp.11-543, 2005. ,
DOI : 10.1093/molehr/gah207
Identification of Genes Regulated by Leukemia-Inhibitory Factor in the Mouse Uterus at the Time of Implantation, Molecular Endocrinology, vol.18, issue.9, pp.2185-2195, 2004. ,
DOI : 10.1210/me.2004-0110
Dysregulation of EGF Family of Growth Factors and COX-2 in the Uterus during the Preattachment and Attachment Reactions of the Blastocyst with the Luminal Epithelium Correlates with Implantation Failure in LIF- Deficient Mice, Molecular Endocrinology, vol.14, issue.8, pp.14-1147, 2000. ,
DOI : 10.1210/mend.14.8.0498
Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus, Mol. Endocrinol, vol.9, pp.691-705, 1995. ,
Expression of Amphiregulin During the Pre- and Post-implantation Period in the Mouse Reproductive Tract, Journal of Reproduction and Development, vol.52, issue.6, pp.52-781, 2006. ,
DOI : 10.1262/jrd.18034
Implantation and Decidualization Defects in Prolactin Receptor (PRLR)-Deficient Mice Are Mediated by Ovarian But Not Uterine PRLR, Endocrinology, vol.141, issue.5, pp.1872-1881, 2000. ,
DOI : 10.1210/en.141.5.1872
EGF-Like Growth Factors As Mediators of LH Action in the Ovulatory Follicle, Science, vol.303, issue.5658, pp.682-684, 2004. ,
DOI : 10.1126/science.1092463
Amphiregulin is expressed in primary cultures of prostate myofibroblasts, fibroblasts, epithelial cells, and in prostate tissue, Prostate Cancer and Prostatic Diseases, vol.1, issue.5, pp.262-267, 1998. ,
DOI : 10.1038/sj.pcan.4500250
The Wilms Tumor Suppressor WT1 Encodes a Transcriptional Activator of amphiregulin, Cell, vol.98, issue.5, pp.663-673, 1999. ,
DOI : 10.1016/S0092-8674(00)80053-7
EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney, Am. J. Physiol, pp.273-463, 1997. ,
Amphiregulin in lung branching morphogenesis: interaction with heparan sulfate proteoglycan modulates cell proliferation, Development, vol.122, pp.1759-1767, 1996. ,
Amphiregulin: A new growth factor in hepatocarcinogenesis, Cancer Letters, vol.254, issue.1, pp.30-41, 2007. ,
DOI : 10.1016/j.canlet.2007.01.015
Local Expression of Epidermal Growth Factor-Like Growth Factors in Human Testis and Its Role in Spermatogenesis, Journal of Andrology, vol.33, issue.1, 2011. ,
DOI : 10.2164/jandrol.110.011981
Amphiregulin Is a Novel Growth Factor Involved in Normal Bone Development and in the Cellular Response to Parathyroid Hormone Stimulation, Journal of Biological Chemistry, vol.280, issue.5, pp.280-3974, 2005. ,
DOI : 10.1074/jbc.M409807200
Stimulation of amphiregulin expression in osteoblastic cells by parathyroid hormone requires the protein kinase A and cAMP response elementbinding protein signaling pathway, J. Cell. Biochem, pp.96-632, 2005. ,
Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells, BMC Genomics, vol.9, issue.1, 2008. ,
DOI : 10.1186/1471-2164-9-166
Amphiregulin is a mitogen for adult neural stem cells, Journal of Neuroscience Research, vol.2, issue.6, pp.757-762, 2002. ,
DOI : 10.1002/jnr.10410
Early changes in gene expression in the dorsal root ganglia after transection of the sciatic nerve; effects of amphiregulin and PAI-1 on regeneration, Molecular Brain Research, vol.136, issue.1-2, pp.65-74, 2005. ,
DOI : 10.1016/j.molbrainres.2005.01.008
Retinoid-Induced Epidermal Hyperplasia Is Mediated by Epidermal Growth Factor Receptor Activation Via Specific Induction of its Ligands Heparin-Binding EGF and Amphiregulin in Human Skin In Vivo, Journal of Investigative Dermatology, vol.126, issue.4, pp.126-732, 2006. ,
DOI : 10.1038/sj.jid.5700202
Epidermal growth factorrelated peptides in the pathogenesis of human breast cancer, Breast Cancer Res. Treat, pp.29-40, 1994. ,
The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis, Hepatology, vol.48, pp.1251-1261, 2008. ,
KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin, Development, vol.136, issue.13, pp.2153-2164, 2009. ,
DOI : 10.1242/dev.031427
A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin., Molecular and Cellular Biology, vol.11, issue.5, pp.11-2547, 1991. ,
DOI : 10.1128/MCB.11.5.2547
Amphiregulin Causes Functional Downregulation of Adherens Junctions in Psoriasis, Journal of Investigative Dermatology, vol.124, issue.6, pp.1134-1140, 2005. ,
DOI : 10.1111/j.0022-202X.2005.23762.x
Amphiregulin Carboxy-Terminal Domain Is Required for Autocrine Keratinocyte Growth, Journal of Investigative Dermatology, vol.130, issue.8, pp.2031-2040 ,
DOI : 10.1038/jid.2010.98
Hallmarks of Cancer: The Next Generation, Cell, vol.144, issue.5, pp.646-674, 2011. ,
DOI : 10.1016/j.cell.2011.02.013
Amphiregulin: Role in Mammary Gland Development and Breast Cancer, Journal of Mammary Gland Biology and Neoplasia, vol.11, issue.12, pp.159-169, 2008. ,
DOI : 10.1007/s10911-008-9075-7
Epidermal Growth Factor Receptor Pathway Analysis Identifies Amphiregulin as a Key Factor for Cisplatin Resistance of Human Breast Cancer Cells, Journal of Biological Chemistry, vol.283, issue.2, pp.739-750, 2008. ,
DOI : 10.1074/jbc.M706287200
Plasma transforming growth factor {alpha} and amphiregulin protein levels in NCIC Clinical Trials Group BR, J. Clin. Oncol, vol.21, 2010. ,
Increases of Amphiregulin and Transforming Growth Factor-?? in Serum as Predictors of Poor Response to Gefitinib among Patients with Advanced Non-Small Cell Lung Cancers, Cancer Research, vol.65, issue.20, pp.9176-9184, 2005. ,
DOI : 10.1158/0008-5472.CAN-05-1556
The Hallmarks of Cancer, Cell, vol.100, issue.1, pp.57-70, 2000. ,
DOI : 10.1016/S0092-8674(00)81683-9
Amphiregulin as an autocrine growth factor for c-Ha-ras- and c-erbB-2-transformed human mammary epithelial cells., Proceedings of the National Academy of Sciences, vol.91, issue.7, pp.91-2790, 1994. ,
DOI : 10.1073/pnas.91.7.2790
A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin, Oncogene, vol.20, issue.30, pp.4019-4028, 2001. ,
DOI : 10.1038/sj.onc.1204537
Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells, Cancer Res, pp.66-6129, 2006. ,
Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines, J. Biol. Chem, pp.277-49127, 2002. ,
Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon, The Journal of Cell Biology, vol.118, issue.3, pp.741-751, 1992. ,
DOI : 10.1083/jcb.118.3.741
Amphiregulin and hepatocyte-derived extracellular matrix regulate proliferation and autocrine growth factor expression in colon cancer cell lines of varying liver-colonizing capability, J. Cell. Biochem, pp.76-332, 1999. ,
Amphiregulin is a potent mitogen for the vascular smooth muscle cell line, A7r5, Biochemical and Biophysical Research Communications, vol.301, issue.4, pp.301-1109, 2003. ,
DOI : 10.1016/S0006-291X(03)00093-7
Antisense expression for amphiregulin suppresses tumorigenicity of a transformed human breast epithelial cell line, Oncogene, vol.18, issue.47, pp.6513-6520, 1999. ,
DOI : 10.1038/sj.onc.1203042
Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy, International Journal of Cancer, vol.7, issue.3, pp.512-517, 1997. ,
DOI : 10.1002/(SICI)1097-0215(19970729)72:3<512::AID-IJC21>3.0.CO;2-C
Differential immunohistochemical detection of amphiregulin and cripto in human normal colon and colorectal tumors, Cancer Res, vol.52, pp.3467-3473, 1992. ,
Amphiregulin, epidermal growth factor receptor, and estrogen receptor expression in human primary breast cancer, Cancer Res, vol.53, pp.3597-3602, 1993. ,
Differential immunohistochemical detection of transforming growth factor ??, amphiregulin and CRIPTO in human normal and malignant breast tissues, International Journal of Cancer, vol.420, issue.1, pp.51-56, 1996. ,
DOI : 10.1002/(SICI)1097-0215(19960103)65:1<51::AID-IJC9>3.0.CO;2-0
Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor, Proceedings of the National Academy of Sciences, vol.96, issue.11, pp.96-6235, 1999. ,
DOI : 10.1073/pnas.96.11.6235
Amphiregulin Carboxy-Terminal Domain Is Required for Autocrine Keratinocyte Growth, Journal of Investigative Dermatology, vol.130, issue.8, pp.130-2031, 2010. ,
DOI : 10.1038/jid.2010.98
The Gene Expression Program of Prostate Fibroblast Senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms, Cancer Research, vol.66, issue.2, pp.794-802, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-1716
Alteration of the serum levels of the epidermal growth factor receptor and its ligands in patients with non-small cell lung cancer and head and neck carcinoma, British Journal of Cancer, vol.10, issue.10, pp.1569-1578, 2007. ,
DOI : 10.1002/(SICI)1097-0142(19960315)77:6<1056::AID-CNCR8>3.0.CO;2-F
Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice, Journal of Clinical Investigation, vol.120, issue.8, pp.2731-2744, 2010. ,
DOI : 10.1172/JCI42686DS1
Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax-and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells, J. Biol. Chem, pp.280-19757, 2005. ,
URL : https://hal.archives-ouvertes.fr/inserm-00340599
Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis, Glia, vol.14, issue.13, pp.1374-1385, 2009. ,
DOI : 10.1002/glia.20856
Mortality and immortality at the cellular level. A review, Biochemistry (Mosc), vol.62, pp.1180-1190, 1997. ,
Influence of aging and cell senescence on telomerase activity in keratinocytes, Journal of Dermatological Science, vol.22, issue.2, pp.22-80, 2000. ,
DOI : 10.1016/S0923-1811(99)00049-3
Targeting the tumour vasculature: insights from physiological angiogenesis, Nature Reviews Cancer, vol.15, issue.7, pp.505-514, 2010. ,
DOI : 10.1038/nrc2868
Regulation of angiogenesis by hypoxia: role of the HIF system, Nature Medicine, vol.9, issue.6, pp.677-684, 2003. ,
DOI : 10.1038/nm0603-677
Hypoxia signalling in cancer and approaches to enforce tumour regression, Nature, vol.9, issue.7092, pp.437-443, 2006. ,
DOI : 10.1038/nature04871
URL : https://hal.archives-ouvertes.fr/hal-00321054
Targeting HIF-1 for cancer therapy, Nature Reviews Cancer, vol.3, issue.10, pp.721-732, 2003. ,
DOI : 10.1038/nrc1187
VEGF and the quest for tumour angiogenesis factors, Nature Reviews Cancer, vol.120, issue.10, pp.795-803, 2002. ,
DOI : 10.1038/nrc909
Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis, Oncogene, vol.59, issue.5, 2010. ,
DOI : 10.1016/j.ccr.2009.09.029
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrowderived cell recruitment, Cancer Cell, pp.15-527, 2009. ,
PHD2 in tumour angiogenesis, British Journal of Cancer, vol.59, issue.1, pp.1-5, 2010. ,
DOI : 10.1073/PNAS.181341498
Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization, Cell, vol.136, issue.5, pp.839-851, 2009. ,
DOI : 10.1016/j.cell.2009.01.020
Transforming growth factor ?-1 and amphiregulin act in synergy to increase the production of urokinase-type plasminogen activator in transformed breast epithelial cells, International Journal of Cancer, vol.13, issue.6, pp.769-778, 2003. ,
DOI : 10.1002/ijc.11158
URL : https://hal.archives-ouvertes.fr/inserm-00156319
Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress, Free Radic, Biol. Med, pp.36-782, 2004. ,
Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner, Am. J. Physiol. Cell Physiol, pp.290-592, 2006. ,
Tumor necrosis factor-alpha converting enzyme in the human placenta throughout gestation, Reprod. Sci, pp.15-195, 2008. ,
Endothelin-1 (ET-1) Increases the Expression of Remodeling Genes in Vascular Smooth Muscle through Linked Calcium and cAMP Pathways: ROLE OF A PHOSPHOLIPASE A2(cPLA2)/CYCLOOXYGENASE-2 (COX-2)/PROSTACYCLIN RECEPTOR-DEPENDENT AUTOCRINE LOOP, Journal of Biological Chemistry, vol.285, issue.34, pp.285-25913, 2010. ,
DOI : 10.1074/jbc.M110.139485
HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis, Proc. Natl. Acad. Sci. U.S.A, vol.107, pp.1100-1105, 2010. ,
Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin, Cancer Res, vol.63, pp.5218-5223, 2003. ,
Amphiregulin as a Novel Target for Breast Cancer Therapy, Journal of Mammary Gland Biology and Neoplasia, vol.406, issue.6797, pp.171-179, 2008. ,
DOI : 10.1007/s10911-008-9081-9
Differential regulation of cell proliferation and protease secretion by epidermal growth factor and amphiregulin in tumoral versus normal breast epithelial cells, British Journal of Cancer, vol.84, issue.7, pp.936-945, 2001. ,
DOI : 10.1054/bjoc.2000.1678
Differential expression of epidermal growth factor-related proteins in human colorectal tumors., Proceedings of the National Academy of Sciences, vol.88, issue.17, pp.7792-7796, 1991. ,
DOI : 10.1073/pnas.88.17.7792
Concomitant cell growth and differentiation are dependent on erbB1 and integrin activation in an autonomously surviving colon adenocarcinoma: involvement of autocrine amphiregulin secretion, Anticancer Res, vol.26, pp.2769-2783, 2006. ,
Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells, Cancer Res, vol.60, pp.1121-1128, 2000. ,
Regulation of extracellular matrix metalloproteinase inducer and matrix metalloproteinase expression by amphiregulin in transformed human breast epithelial cells, Cancer Res, vol.63, pp.7575-7580, 2003. ,
Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cells, International Journal of Cancer, vol.264, issue.6, pp.722-726, 1997. ,
DOI : 10.1002/(SICI)1097-0215(19970317)70:6<722::AID-IJC15>3.0.CO;2-B
Regulation of matrix metalloprotease activity in malignant mesothelioma cell lines by growth factors, Thorax, vol.58, issue.3, pp.198-203, 2003. ,
DOI : 10.1136/thorax.58.3.198
Molecular requirements for epithelial???mesenchymal transition during tumor progression, Current Opinion in Cell Biology, vol.17, issue.5, pp.548-558, 2005. ,
DOI : 10.1016/j.ceb.2005.08.001
Cancer Genomics Identifies Regulatory Gene Networks Associated with the Transition from Dysplasia to Advanced Lung Adenocarcinomas Induced by c-Raf-1, PLoS ONE, vol.98, issue.4, p.7315, 2009. ,
DOI : 10.1371/journal.pone.0007315.s009
Involvement of NF-kappaB/miR-448 regulatory feedback loop in chemotherapy-induced epithelial?mesenchymal transition of breast cancer cells, Cell Death Differ, 2010. ,
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway, Nature Cell Biology, vol.50, issue.12, pp.1444-1450, 2009. ,
DOI : 10.1126/science.277.5329.1103
Induction of Anchorage-Independent Growth by Amphiregulin, Growth Factors, vol.14, issue.2, pp.193-203, 1996. ,
DOI : 10.3109/08977199609003221
Amphiregulin anti-sense oligodeoxynucleotides inhibit growth and transformation of a human colon carcinoma cell line, International Journal of Cancer, vol.47, issue.6, pp.762-766, 1995. ,
DOI : 10.1002/ijc.2910620619
Identification of rat pancreatic carcinoma genes associated with lymphogenous metastasis, Anticancer Res, vol.22, pp.2015-2027, 2002. ,
Prediction of liver metastasis after colorectal cancer using reverse transcription-polymerase chain reaction analysis of 10 genes, European Journal of Cancer, vol.46, issue.11, pp.2119-2126, 2010. ,
DOI : 10.1016/j.ejca.2010.04.019
Amphiregulin and Epiregulin Expression in Colorectal Carcinoma and the Correlation with Clinicopathological Characteristics, Onkologie, vol.33, issue.7, pp.353-358, 2010. ,
DOI : 10.1159/000315380
HER Family Receptor Abnormalities in Lung Cancer Brain Metastases and Corresponding Primary Tumors, Clinical Cancer Research, vol.15, issue.15, pp.4829-4837, 2009. ,
DOI : 10.1158/1078-0432.CCR-08-2921
Amphiregulin Is a Promising Prognostic Marker for Liver Metastases of Colorectal Cancer, Clinical Cancer Research, vol.14, issue.8, pp.2351-2356, 2008. ,
DOI : 10.1158/1078-0432.CCR-07-4499
Differential gene expression profiles of radioresistant pancreatic cancer cell lines established by fractionated irradiation, International Journal of Oncology, pp.28-705, 2006. ,
DOI : 10.3892/ijo.28.3.705
Stimulated PI3K-AKT Signaling Mediated through Ligand or Radiation-Induced EGFR Depends Indirectly, but not Directly, on Constitutive K-Ras Activity, Molecular Cancer Research, vol.5, issue.8, pp.863-872, 2007. ,
DOI : 10.1158/1541-7786.MCR-06-0297
Radioresistance of K-Ras mutated human tumor cells is mediated through EGFRdependent activation of PI3K-AKT pathway, Radiother. Oncol, pp.76-143, 2005. ,
Mitochondrial dysfunction-induced amphiregulin upregulation mediates chemo-resistance and cell migration in HepG2 cells, Cellular and Molecular Life Sciences, vol.66, issue.10, pp.1755-1765, 2009. ,
DOI : 10.1007/s00018-009-8767-5
The Role of Amphiregulin in Exemestane-Resistant Breast Cancer Cells: Evidence of an Autocrine Loop, Cancer Research, vol.68, issue.7, pp.2259-2265, 2008. ,
DOI : 10.1158/0008-5472.CAN-07-5544
Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I?IIIA non-smallcell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival, Clin. Cancer Res, vol.4, pp.241-249, 1998. ,
Clinicopathologic analysis of amphiregulin and heregulin immunostaining in breast neoplasia, Breast Cancer Research and Treatment, vol.10, issue.1, pp.45-75, 1997. ,
DOI : 10.1023/A:1005845512804
Amphiregulin expression in prostatic intraepithelial neoplasia and adenocarcinoma: A study of 93 cases, The Prostate, vol.82, issue.2, pp.164-168, 2004. ,
DOI : 10.1002/pros.10322
Induction and expression of amphiregulin in human pancreatic cancer, Cancer Res, pp.54-3959, 1994. ,
Amphiregulin and epiregulin expression in neoplastic and inflammatory lesions in the colon, Oncology Reports, vol.19, pp.105-110, 2008. ,
DOI : 10.3892/or.19.1.105
A subclass of HER1 ligands are prognostic markers for survival in bladder cancer patients, Cancer Res, pp.61-6227, 2001. ,
Pancreatic Cancer - New Aspects of Molecular Biology Research, Swiss Surgery, vol.6, issue.5, pp.231-234, 2000. ,
DOI : 10.1024/1023-9332.6.5.231
Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas, Int. J. Oncol, vol.21, pp.941-948, 2002. ,
Epidermal growth factor-related peptides and their receptors in human malignancies, Critical Reviews in Oncology/Hematology, vol.19, issue.3, pp.183-232, 1995. ,
DOI : 10.1016/1040-8428(94)00144-I
ERBB receptors and cancer: the complexity of targeted inhibitors, Nature Reviews Cancer, vol.7, issue.5, pp.341-354, 2005. ,
DOI : 10.1021/jm00130a020
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab, J. Clin. Oncol, pp.25-3230, 2007. ,
Amphiregulin and Epiregulin mRNA Expression in Primary Tumors Predicts Outcome in Metastatic Colorectal Cancer Treated With Cetuximab, Journal of Clinical Oncology, vol.27, issue.30, pp.27-5068, 2009. ,
DOI : 10.1200/JCO.2008.21.3744
Evolution of the predictive markers amphiregulin and epiregulin mRNAs during long-term cetuximab treatment of KRAS wild-type tumor cells, Investigational New Drugs, vol.103, issue.2, 2010. ,
DOI : 10.1007/s10637-010-9612-2
The stem cell property epithelial-to-mesenchymal transition (EMT) is a core transcriptional network for predicting cetuximab (Erbitux) efficacy in KRAS wild-type tumor cells, J Cell Biochem, 2010. ,
Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer, British Journal of Cancer, vol.9, issue.3, pp.488-495, 2011. ,
DOI : 10.1126/science.1073096
Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: Activation of MET as one mechanism for drug resistance, European Journal of Cancer, vol.47, issue.8, 2011. ,
DOI : 10.1016/j.ejca.2010.12.019
Determinants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neck, The Journal of Pathology, vol.271, issue.1, pp.218-122, 2009. ,
DOI : 10.1002/path.2515
Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers, Clin, Cancer Res, vol.14, pp.6963-6973, 2008. ,
Clinical impact of amphiregulin expression in patients with epidermal growth factor receptor (EGFR) wild-type nonsmall cell lung cancer treated with EGFR-tyrosine kinase inhibitors, Cancer, vol.18, issue.1, pp.143-151, 2011. ,
DOI : 10.1002/cncr.25560
Ligands of Epidermal Growth Factor Receptor and the Insulin-Like Growth Factor Family as Serum Biomarkers for Response to Epidermal Growth Factor Receptor Inhibitors in Patients with Advanced Non-small Cell Lung Cancer, Journal of Thoracic Oncology, vol.5, issue.12, pp.1939-1948, 2010. ,
DOI : 10.1097/JTO.0b013e3181f77a39
The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides, Cancer Res, vol.62, pp.3151-3158, 2002. ,
Pathway-focused proteomic signatures in HER2-overexpressing breast cancer with a basal-like phenotype: new insights into de novo resistance to trastuzumab (Herceptin), Int. J. Oncol, vol.37, pp.669-678, 2010. ,
An update of the mechanisms of resistance to EGFR-tyrosine kinase inhibitors in breast cancer: Gefitinib (Iressa???)-induced changes in the expression and nucleo-cytoplasmic trafficking of HER-ligands (Review), International Journal of Molecular Medicine, vol.20, pp.3-10, 2007. ,
DOI : 10.3892/ijmm.20.1.3
Nuclear EGFR contributes to acquired resistance to cetuximab, Oncogene, vol.8, issue.43, pp.3801-3813, 2009. ,
DOI : 10.1038/35052073
Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839), Human Molecular Genetics, vol.13, issue.24, pp.13-3029, 2004. ,
DOI : 10.1093/hmg/ddh331
Biomarkers for prediction of sensitivity to EGFR inhibitors in non-small cell lung cancer, Current Opinion in Oncology, vol.17, issue.2, pp.118-122, 2005. ,
DOI : 10.1097/01.cco.0000155059.39733.9d
Amphiregulin Promotes BAX Inhibition and Resistance to Gefitinib in Non-small-cell Lung Cancers, Molecular Therapy, vol.18, issue.3, pp.528-535, 2010. ,
DOI : 10.1038/mt.2009.226
URL : https://hal.archives-ouvertes.fr/inserm-00425468
Amphiregulin Promotes Resistance to Gefitinib in NonSmall Cell Lung Cancer Cells by Regulating Ku70 Acetylation, Molecular Therapy, vol.18, issue.3, pp.536-543, 2010. ,
DOI : 10.1038/mt.2009.227
URL : https://hal.archives-ouvertes.fr/inserm-00425467
Validation of HB-EGF and amphiregulin as targets for human cancer therapy, Biochemical and Biophysical Research Communications, vol.365, issue.3, pp.365-555, 2008. ,
DOI : 10.1016/j.bbrc.2007.11.015
Amphiregulin-dependent proliferation of cultured human keratinocytes: Autocrine growth, the effects of exogenous recombinant cytokine, and apparent requirement for heparin-like glycosaminoglycans, Journal of Cellular Physiology, vol.64, issue.1, pp.159-114, 1994. ,
DOI : 10.1002/jcp.1041590115
Targeting TACE-dependent EGFR ligand shedding in breast cancer, Journal of Clinical Investigation, vol.117, issue.2, pp.337-345, 2007. ,
DOI : 10.1172/JCI29518DS1
Chemotherapy-Induced Activation of ADAM-17: A Novel Mechanism of Drug Resistance in Colorectal Cancer, Clinical Cancer Research, vol.16, issue.13, pp.3378-3389, 2010. ,
DOI : 10.1158/1078-0432.CCR-10-0014
Anti-sense oligonucleotides directed against EGF-related growth factors enhance anti-proliferative effect of conventional anti-tumor drugs in human colon-cancer cells, International Journal of Cancer, vol.92, issue.2, pp.277-282, 1997. ,
DOI : 10.1002/(SICI)1097-0215(19971009)73:2<277::AID-IJC19>3.0.CO;2-C
Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer, Cancer Science, vol.19, issue.11, pp.2351-2360, 2010. ,
DOI : 10.1111/j.1349-7006.2010.01671.x
Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer, Journal of Carcinogenesis, vol.7, issue.1, 2008. ,
DOI : 10.4103/1477-3163.44372
Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis, Cancer Res, pp.69-1383, 2009. ,
DOI : 10.1158/0008-5472.can-08-3612
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741736
Cross-talk between G Protein-Coupled Receptor and Epidermal Growth Factor Receptor Signaling Pathways Contributes to Growth and Invasion of Head and Neck Squamous Cell Carcinoma, Cancer Research, vol.66, issue.24, pp.11831-11839, 2006. ,
DOI : 10.1158/0008-5472.CAN-06-2876
A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to p38MAPK-dependent activation of mTOR and cyclinD1 expression in prostate and lung cancer cells, The International Journal of Biochemistry & Cell Biology, vol.41, issue.3, pp.41-603, 2009. ,
DOI : 10.1016/j.biocel.2008.07.004
Receptor Heterodimerization: Essential Mechanism for Platelet-Derived Growth Factor-Induced Epidermal Growth Factor Receptor Transactivation, Molecular and Cellular Biology, vol.21, issue.19, pp.6387-6394, 2001. ,
DOI : 10.1128/MCB.21.19.6387-6394.2001
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC99786
Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib, Cancer Res, pp.66-10100, 2006. ,
Amphiregulin Is a Vitamin D3 Target Gene in Squamous Cell and Breast Carcinoma, Biochemical and Biophysical Research Communications, vol.281, issue.4, pp.281-1051, 2001. ,
DOI : 10.1006/bbrc.2001.4466
Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells., Proceedings of the National Academy of Sciences, vol.92, issue.7, pp.92-2840, 1995. ,
DOI : 10.1073/pnas.92.7.2840
Regulation of Amphiregulin mRNA by TGF-?? in the Human Lung Adenocarcinoma Cell Line A549, Growth Factors, vol.263, issue.3, pp.207-213, 1992. ,
DOI : 10.1146/annurev.cb.06.110190.003121
Induction of heparin binding epidermal growth factorlike growth factor and amphiregulin mRNAs by gastrin in the rat stomach, Biochem. Biophys. Res. Commun, pp.235-520, 1997. ,
Phosphorylation of TNF-?? converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation, Proceedings of the National Academy of Sciences, vol.103, issue.18, pp.6901-6906, 2006. ,
DOI : 10.1073/pnas.0509719103
Roles of Myofibroblasts in Prostaglandin E2-Stimulated Intestinal Epithelial Proliferation and Angiogenesis, Cancer Research, vol.66, issue.2, pp.846-855, 2006. ,
DOI : 10.1158/0008-5472.CAN-05-2606
Epidermal growth factor receptor-dependent stimulation of amphiregulin expression in androgen-stimulated human prostate cancer cells., Molecular Biology of the Cell, vol.5, issue.3, pp.339-347, 1994. ,
DOI : 10.1091/mbc.5.3.339
Disruption of estrogen signaling does not prevent progesterone action in the estrogen receptor alpha knockout mouse uterus, Proc. Natl. Acad. Sci. U.S.A, pp.96-3646, 1999. ,
Indian Hedgehog, But Not Histidine Decarboxylase or Amphiregulin, Is a Progesterone-Regulated Uterine Gene in Hamsters, Endocrinology, vol.147, issue.9, pp.4079-4092, 2006. ,
DOI : 10.1210/en.2006-0231
2-Methoxyestradiol Induces Mammary Gland Differentiation through Amphiregulin-Epithelial Growth Factor Receptor-Mediated Signaling: Molecular Distinctions from the Mammary Gland of Pregnant Mice, Endocrinology, vol.148, issue.3, pp.1266-1277, 2007. ,
DOI : 10.1210/en.2006-0964
Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines, Breast Cancer Res. Endocrinology, vol.9, issue.136, pp.3983-3992, 1995. ,
Regulation of amphiregulin, EGFR-like factor expression by hCG in cultured human granulosa cells, Acta Obstetricia et Gynecologica Scandinavica, vol.86, issue.6, pp.86-706, 2007. ,
DOI : 10.1080/00016340701314959
The Epidermal Growth Factor-Like Growth Factor Amphiregulin Is Strongly Induced by the Adenosine 3???,5???-Monophosphate Pathway in Various Cell Types, Endocrinology, vol.145, issue.11, pp.5177-5184, 2004. ,
DOI : 10.1210/en.2004-0232
Insulin induces a transcriptional activation of epiregulin, HB-EGF and amphiregulin, by a PI3K-dependent mechanism: Identification of a specific insulin-responsive promoter element, Biochemical and Biophysical Research Communications, vol.354, issue.4, pp.354-885, 2007. ,
DOI : 10.1016/j.bbrc.2007.01.047
Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1, Journal of Cellular Physiology, vol.99, issue.2, pp.163-257, 1995. ,
DOI : 10.1002/jcp.1041630206
Oxidative stress increases gene expression of heparinbinding EGF-like growth factor and amphiregulin in cultured rat gastric epithelial cells, Biochem. Biophys. Res. Commun, pp.226-542, 1996. ,
Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx, Molecular Biology of the Cell, vol.18, issue.1, pp.176-188, 2007. ,
DOI : 10.1091/mbc.E06-01-0014
Baeza-Squiban, Fine particulate matter induces amphiregulin secretion by bronchial epithelial cells, Am. J. Respir. Cell Mol. Biol, pp.30-421, 2004. ,
DOI : 10.1165/rcmb.2003-0281rc
Baeza- Squiban, Effects of PM2.5 components in the release of amphiregulin by human airway epithelial cells, Toxicol. Lett, pp.168-155, 2007. ,
-tetrachlorodi- benzo-p-dioxin induces amphiregulin gene expression in the developing mouse ureter, Toxicol. Sci, vol.7, issue.8, pp.94-163, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00857436
Tobacco Smoke Stimulates the Transcription of Amphiregulin in Human Oral Epithelial Cells: Evidence of a Cyclic AMP-Responsive Element Binding Protein-Dependent Mechanism, Cancer Research, vol.65, issue.13, pp.65-5982, 2005. ,
DOI : 10.1158/0008-5472.CAN-05-0628
Tobacco smokeinduced lung cell proliferation mediated by tumor necrosis factor alphaconverting enzyme and amphiregulin, J. Biol. Chem, pp.278-26202, 2003. ,
Tyrosine Phosphorylation and Proteolysis: PERVANADATE-INDUCED, METALLOPROTEASE-DEPENDENT CLEAVAGE OF THE ErbB-4 RECEPTOR AND AMPHIREGULIN, Journal of Biological Chemistry, vol.273, issue.32, pp.273-20589, 1998. ,
DOI : 10.1074/jbc.273.32.20589
Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas, Breast Cancer Research and Treatment, vol.256, issue.3, pp.35-293, 1995. ,
DOI : 10.1007/BF00665981
The increasing role of amphiregulin in non-small cell lung cancer, Pathologie Biologie, vol.57, issue.7-8, pp.511-512, 2009. ,
DOI : 10.1016/j.patbio.2008.10.002
URL : https://hal.archives-ouvertes.fr/inserm-00333661
Amphiregulin messenger RNA is elevated in psoriatic epidermis and gastrointestinal carcinomas, Cancer Res, pp.52-3224, 1992. ,
Frequent expression of genes for receptor tyrosine kinases and their ligands in human pancreatic cancer cells, Int. J. Pancreatol, vol.18, pp.15-23, 1995. ,
Functions of epidermal growth factor-like growth factors during human urothelial reepithelialization in vitro and the role of erbB2, Urol. Res, pp.30-240, 2002. ,
Identification of novel cellular targets in biliary tract cancers using global gene expression technology, Am. J. Pathol, vol.163, pp.217-229, 2003. ,
Amphiregulin Overexpression Results in Rapidly Growing Keratinocytic Tumors, The American Journal of Pathology, vol.163, issue.6, pp.163-2451, 2003. ,
DOI : 10.1016/S0002-9440(10)63600-0
Expression and regulation of c-ERBB ligands in human head and neck squamous carcinoma cells, Int. J. Cancer, vol.88, pp.759-765, 2000. ,
Amphiregulin and epidermal growth factor receptor expression in human malignant fibrous histiocytoma of soft tissues, Anticancer Res, vol.24, pp.1307-1310, 2004. ,
Expression of EGF-family receptors and amphiregulin in multiple myeloma, Amphiregulin is a growth factor for myeloma cells, Oncogene, vol.24, pp.3512-3524, 2005. ,
URL : https://hal.archives-ouvertes.fr/inserm-00130206