Nuclear receptors linking circadian rhythms and cardiometabolic control.

Hélène Duez (1) , Bart Staels (1)

1 RNMCD - Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011

Many behavioral and physiological processes, including locomotor activity, blood pressure, body temperature, sleep (fasting)/wake (feeding) cycles, and metabolic regulation display diurnal rhythms. The biological clock ensures proper metabolic alignment of energy substrate availability and processing. Studies in animals and humans highlight a strong link between circadian disorders and altered metabolic responses and cardiovascular events. Shift work, for instance, increases the risk to develop metabolic abnormalities resembling the metabolic syndrome. Nuclear receptors have long been known as metabolic regulators. Several of them (ie, Rev-erbalpha, RORalpha, and peroxisome proliferation-activated receptors) are subjected to circadian variations and are integral components of molecular clock machinery. In turn, these nuclear receptors regulate downstream target genes in a circadian manner, acting to properly gate metabolic events to the appropriate circadian time window.

Mots clés: circadian rhythm; cardiometabolic disorders; nuclear receptors; Rev-erbalpha; RORalpha; PPAR; PGC1alpha; biological clock; metabolic syndrome

Domaines: Biochimie, Biologie Moléculaire

Hélène Duez, Bart Staels. Nuclear receptors linking circadian rhythms and cardiometabolic control.. Arteriosclerosis, Thrombosis, and Vascular Biology, 2010, 30 (8), pp.1529-34. ⟨10.1161/ATVBAHA.110.209098⟩. ⟨inserm-00504147⟩