D. Hartong, . Berson, . Dryja, and . Tp, Retinitis pigmentosa, The Lancet, vol.368, issue.9549, pp.1795-1809, 2006.
DOI : 10.1016/S0140-6736(06)69740-7

P. Rosenfeld, . Cowley, . Gs, . Mcgee, . Tl et al., A Null mutation in the rhodopsin gene causes rod photoreceptor dysfunction and autosomal recessive retinitis pigmentosa, Nature Genetics, vol.99, issue.3, pp.209-213, 1992.
DOI : 10.1038/338070a0

M. Mclaughlin, M. Sandberg, . Berson, . Dryja, and . Tp, Recessive mutations in the gene encoding the ?????subunit of rod phosphodiesterase in patients with retinitis pigmentosa, Nature Genetics, vol.90, issue.2, pp.130-134, 1993.
DOI : 10.1038/342762a0

S. Mangel and J. Dowling, The Interplexiform-Horizontal Cell System of the Fish Retina: Effects of Dopamine, Light Stimulation and Time in the Dark, Proceedings of the Royal Society B: Biological Sciences, vol.231, issue.1262, pp.91-121, 1987.
DOI : 10.1098/rspb.1987.0037

A. Geller and P. Sieving, Assessment of foveal cone photoreceptors in Stargardt's macular dystrophy using a small dot detection task, Vision Research, vol.33, issue.11, pp.1509-1533, 1993.
DOI : 10.1016/0042-6989(93)90144-L

A. Wright, A searchlight through the fog, Nature Genetics, vol.111, issue.2, pp.132-134, 1997.
DOI : 10.1038/ng0995-27

S. Mohand-said, D. Hicks, . Dreyfus, and J. Sahel, Selective Transplantation of Rods Delays Cone Loss in a Retinitis Pigmentosa Model, Archives of Ophthalmology, vol.118, issue.6, pp.807-811, 2000.
DOI : 10.1001/archopht.118.6.807

S. Mohand-said, D. Hicks, M. Simonutti, D. Tran-minh, A. Deudon-combe et al., Photoreceptor Transplants Increase Host Cone Survival in the Retinal Degeneration (rd) Mouse, Ophthalmic Research, vol.29, issue.5, pp.290-297, 1997.
DOI : 10.1159/000268027

S. Mohand-said, A. Deudon-combe, D. Hicks, M. Simonutti, V. Forster et al., Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse, Proceedings of the National Academy of Sciences, vol.95, issue.14, pp.8357-8362, 1998.
DOI : 10.1073/pnas.95.14.8357

A. Fintz, I. Audo, D. Hicks, S. Mohand-said, . Léveillard et al., Partial Characterization of Retina-Derived Cone Neuroprotection in Two Culture Models of Photoreceptor Degeneration, Investigative Opthalmology & Visual Science, vol.44, issue.2, pp.818-825, 2003.
DOI : 10.1167/iovs.01-1144

T. Léveillard, S. Mohand-saïd, O. Lorentz, D. Hicks, . Fintz et al., Identification and characterization of rod-derived cone viability factor, Nature Genetics, vol.124, issue.7, pp.755-759, 2004.
DOI : 10.1093/nar/25.17.3389

M. Frasson, S. Picaud, T. Léveillard, M. Simonutti, S. Mohand-said et al., Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse, Invest Ophthalmol Vis Sci, vol.40, pp.2724-2734, 1999.

C. Bowes, T. Li, M. Danciger, . Baxter, . Lc et al., Retinal degeneration in the rd mouse is caused by a defect in the ?? subunit of rod cGMP-phosphodiesterase, Nature, vol.347, issue.6294, pp.677-680, 1990.
DOI : 10.1038/347677a0

T. Cronin, . Léveillard, and J. Sahel, Retinal Degenerations: From Cell Signaling to Cell Therapy; Pre-Clinical and Clinical Issues, Current Gene Therapy, vol.7, issue.2, pp.121-129, 2007.
DOI : 10.2174/156652307780363143

R. Wen, Y. Song, S. Kjellstrom, A. Tanikawa, Y. Liu et al., Regulation of Rod Phototransduction Machinery by Ciliary Neurotrophic Factor, Journal of Neuroscience, vol.26, issue.52, pp.13523-13530, 2006.
DOI : 10.1523/JNEUROSCI.4021-06.2006

P. Sieving, R. Caruso, W. Tao, . Coleman, . Hr et al., Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants, Proceedings of the National Academy of Sciences, vol.103, issue.10, pp.3896-3901, 2006.
DOI : 10.1073/pnas.0600236103

D. Lee, S. Geller, N. Walsh, K. Valter, D. Yasumura et al., Photoreceptor Degeneration in Pro23His and S334ter Transgenic Rats, Adv Exp Med Biol, vol.533, pp.297-302, 2003.
DOI : 10.1007/978-1-4615-0067-4_36

S. Machida, M. Kondo, J. Jamison, . Khan, . Nw et al., P23H rhodopsin transgenic rat: correlation of retinal function with histopathology, Invest Ophthalmol Vis Sci, vol.41, pp.3200-3209, 2000.

L. Carter-dawson, . Lavail, and R. Sidman, Differential effect of the rd mutation on rods and cones in the mouse retina, Invest Ophthalmol Vis Sci, vol.17, pp.489-498, 1978.

F. Chalmel, T. Léveillard, C. Jaillard, A. Lardenois, N. Berdugo et al., Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential, BMC Molecular Biology, vol.8, issue.1, p.74, 2007.
DOI : 10.1186/1471-2199-8-74

URL : https://hal.archives-ouvertes.fr/hal-00188911

S. Aizawa, Y. Mitamura, T. Baba, A. Hagiwara, . Ogata et al., Correlation between retinal sensitivity and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa, Br J Ophthalmol, vol.93, pp.126-127, 2009.

C. Punzo, K. Kornacker, and C. Cepko, Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa, Nature Neuroscience, vol.22, issue.1, pp.44-52, 2009.
DOI : 10.1038/nn.2234

T. Dryja, . Mcgee, . Tl, E. Reichel, . Hahn et al., A point mutation of the rhodopsin gene in one form of retinitis pigmentosa, Nature, vol.343, issue.6256, pp.364-366, 1990.
DOI : 10.1038/343364a0

R. Petters, C. Alexander, . Wells, . Kd, . Collins et al., Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa, Nature Biotechnology, vol.112, issue.10, pp.965-970, 1997.
DOI : 10.1016/0042-6989(95)00327-4

M. Naash, J. Hollyfield, . Ubaidi, . Mr, and W. Baehr, Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene., Proceedings of the National Academy of Sciences, vol.90, issue.12, pp.5499-5503, 1993.
DOI : 10.1073/pnas.90.12.5499

Y. Goto, . Peachey, . Ns, . Ripps, and M. Naash, Functional abnormalities in transgenic mice expressing a mutant rhodopsin gene, Invest Ophthalmol Vis Sci, vol.36, pp.62-71, 1995.

M. Mccall, R. Gregg, K. Merriman, Y. Goto, . Peachey et al., Morphological and Physiological Consequences of the Selective Elimination of Rod Photoreceptors in Transgenic Mice, Experimental Eye Research, vol.63, issue.1, pp.35-50, 1996.
DOI : 10.1006/exer.1996.0089

A. Hewitt, J. Lindsey, . Carbott, and R. Adler, Photoreceptor survival-promoting activity in interphotoreceptor matrix preparations: Characterization and partial purification, Experimental Eye Research, vol.50, issue.1, pp.79-88, 1990.
DOI : 10.1016/0014-4835(90)90013-K

P. Huang, A. Gaitan, Y. Hao, . Petters, and F. Wong, Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene., Proceedings of the National Academy of Sciences, vol.90, issue.18, pp.8484-8492, 1993.
DOI : 10.1073/pnas.90.18.8484

W. Kedzierski, . Bok, and G. Travis, Non-cell-autonomous photoreceptor degeneration in rds mutant mice mosaic for expression of a rescue transgene, J Neurosci, vol.18, pp.4076-4082, 1998.

P. Goldsmith, . Baier, . Harris, and . Wa, Two zebrafish mutants,ebony andivory, uncover benefits of neighborhood on photoreceptor survival, Journal of Neurobiology, vol.31, issue.3, pp.235-245, 2003.
DOI : 10.1002/neu.10274

C. Portera-cailliau, . Sung, . Ch, . Nathans, and R. Adler, Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa., Proceedings of the National Academy of Sciences, vol.91, issue.3, pp.974-978, 1994.
DOI : 10.1073/pnas.91.3.974

R. Lolley, . Rayborn, . Me, . Hollyfield, . Farber et al., Cyclic GMP and visual cell degeneration in the inherited disorder of rd mice: a progress report, Vision Research, vol.20, issue.12, pp.1157-1161, 1980.
DOI : 10.1016/0042-6989(80)90054-1

G. Vallazza-deschamps, D. Cia, J. Gong, A. Jellali, A. Duboc et al., Excessive activation of cyclic nucleotide-gated channels contributes to neuronal degeneration of photoreceptors, European Journal of Neuroscience, vol.68, issue.Suppl. 3, pp.1013-1022, 2005.
DOI : 10.1111/j.1460-9568.2005.04306.x

URL : https://hal.archives-ouvertes.fr/hal-00143250

D. Sanges, A. Comitato, . Tammaro, and V. Marigo, Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors, Proceedings of the National Academy of Sciences, vol.103, issue.46, pp.17366-17371, 2006.
DOI : 10.1073/pnas.0606276103

M. Gorbatyuk, V. Justilien, J. Liu, . Hauswirth, and L. Ww, Suppression of mouse rhodopsin expression in vivo by AAV mediated siRNA delivery, Vision Research, vol.47, issue.9, pp.1202-1208, 2007.
DOI : 10.1016/j.visres.2006.11.026

V. Chrysostomou, J. Stone, S. Stowe, . Barnett, and K. Valter, The Status of Cones in the Rhodopsin Mutant P23H-3 Retina: Light-Regulated Damage and Repair in Parallel with Rods, Investigative Opthalmology & Visual Science, vol.49, issue.3, pp.1116-1125, 2008.
DOI : 10.1167/iovs.07-1158

X. Wang, . Tan, . Bz, M. Sun, B. Ho et al., Thioredoxin-like 6 protects retinal cell line from photooxidative damage by upregulating NF-??B activity, Free Radical Biology and Medicine, vol.45, issue.3, pp.336-344, 2008.
DOI : 10.1016/j.freeradbiomed.2008.04.028

R. Steinberg, . Fisher, and D. Anderson, Disc morphogenesis in vertebrate photoreceptors, The Journal of Comparative Neurology, vol.42, issue.3, pp.501-508, 1980.
DOI : 10.1002/cne.901900307

M. Delyfer, T. Léveillard, S. Mohand-said, D. Hicks, . Picaud et al., Inherited retinal degenerations: therapeutic prospects, Biology of the Cell, vol.96, issue.4, pp.261-269, 2004.
DOI : 10.1111/j.1768-322X.2004.tb01414.x

E. Faktorovich, R. Steinberg, D. Yasumura, . Matthes, . Lavail et al., Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor, Nature, vol.347, issue.6288, pp.83-86, 1990.
DOI : 10.1038/347083a0

K. Rhee, A. Ruiz, J. Duncan, . Hauswirth, . Ww et al., Molecular and Cellular Alterations Induced by Sustained Expression of Ciliary Neurotrophic Factor in a Mouse Model of Retinitis Pigmentosa, Investigative Opthalmology & Visual Science, vol.48, issue.3, pp.1389-1400, 2007.
DOI : 10.1167/iovs.06-0677

M. Sanftner, . Lh, H. Abel, . Hauswirth, and J. Flannery, Glial Cell Line Derived Neurotrophic Factor Delays Photoreceptor Degeneration in a Transgenic Rat Model of Retinitis Pigmentosa, Molecular Therapy, vol.4, issue.6, pp.622-629, 2001.
DOI : 10.1006/mthe.2001.0498

P. Buch, R. Maclaren, Y. Duran, . Balaggan, . Ks et al., In Contrast to AAV-Mediated Cntf Expression, AAV-Mediated Gdnf Expression Enhances Gene Replacement Therapy in Rodent Models of Retinal Degeneration, Molecular Therapy, vol.14, issue.5, pp.700-709, 2006.
DOI : 10.1016/j.ymthe.2006.05.019

N. Chong, . Bird, and . Ac, Management of inherited outer retinal dystrophies: present and future, British Journal of Ophthalmology, vol.83, issue.1, pp.120-122, 1999.
DOI : 10.1136/bjo.83.1.120

S. Hanein, I. Perrault, S. Gerber, H. Dollfus, J. Dufier et al., Disease-Associated Variants of the Rod-derived Cone Viability Factor (RdCVF) in Leber Congenital Amaurosis, Adv Exp Med Biol, vol.572, pp.9-14, 2006.
DOI : 10.1007/0-387-32442-9_2

P. Rosenfeld, . Brown, . Dm, J. Heier, . Boyer et al., Ranibizumab for Neovascular Age-Related Macular Degeneration, New England Journal of Medicine, vol.355, issue.14, pp.1419-1431, 2006.
DOI : 10.1056/NEJMoa054481

W. Tao, Application of encapsulated cell technology for retinal degenerative diseases, Expert Opinion on Biological Therapy, vol.155, issue.7, pp.717-726, 2006.
DOI : 10.1046/j.1365-2249.2002.01969.x

A. Maguire, F. Simonelli, . Pierce, . Ea, . Pugh et al., Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis, New England Journal of Medicine, vol.358, issue.21, pp.2240-2248, 2008.
DOI : 10.1056/NEJMoa0802315

J. Bainbridge, . Smith, . Barker, . Ss, S. Robbie et al., Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis, New England Journal of Medicine, vol.358, issue.21, pp.2231-2239, 2008.
DOI : 10.1056/NEJMoa0802268