C. Huggins, Endocrine-induced regression of cancers, The American Journal of Surgery, vol.136, issue.2, pp.1050-1054, 1967.
DOI : 10.1016/0002-9610(78)90235-0

B. Feldman and D. Feldman, The development of androgen-independent prostate cancer, Nature Reviews Cancer, vol.1, issue.1, pp.34-45, 2001.
DOI : 10.1038/35094009

L. Lim, N. Lau, P. Garrett-engele, A. Grimson, and J. Schelter, Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs, Nature, vol.22, issue.7027, pp.769-773, 2005.
DOI : 10.1016/S0092-8674(00)00015-5

L. He and G. Hannon, MicroRNAs: small RNAs with a big role in gene regulation, Nature Reviews Genetics, vol.1, issue.7, pp.522-531, 2004.
DOI : 10.1038/nature02363

T. Thum, C. Gross, J. Fiedler, T. Fischer, and S. Kissler, MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts, Nature, vol.100, issue.7224, pp.980-984, 2008.
DOI : 10.1038/nature07511

A. Care, D. Catalucci, F. Felicetti, D. Bonci, and A. Addario, MicroRNA-133 controls cardiac hypertrophy, Nature Medicine, vol.10, issue.5, pp.613-618, 2007.
DOI : 10.1038/nm1582

D. Bartel, MicroRNAs, Cell, vol.116, issue.2, pp.281-297, 2004.
DOI : 10.1016/S0092-8674(04)00045-5
URL : https://hal.archives-ouvertes.fr/hal-00369966

G. Calin, C. Sevignani, C. Dumitru, T. Hyslop, and E. Noch, Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers, Proceedings of the National Academy of Sciences, vol.101, issue.9, pp.2999-3004, 2004.
DOI : 10.1073/pnas.0307323101
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC365734

A. Esquela-kerscher and F. Slack, Oncomirs ??? microRNAs with a role in cancer, Nature Reviews Cancer, vol.102, issue.4, pp.259-269, 2006.
DOI : 10.1038/nrc1840

S. Volinia, G. Calin, C. Liu, S. Ambs, and A. Cimmino, A microRNA expression signature of human solid tumors defines cancer gene targets, Proceedings of the National Academy of Sciences, vol.103, issue.7, pp.2257-2261, 2006.
DOI : 10.1073/pnas.0510565103

G. Calin and C. Croce, MicroRNA signatures in human cancers, Nature Reviews Cancer, vol.59, issue.11, pp.857-866, 2006.
DOI : 10.1677/erc.1.01209

D. Bonci, V. Coppola, M. Musumeci, A. Addario, and R. Giuffrida, THE MIR-15A/MIR-16-1 CLUSTER CONTROLS PROSTATE CANCER PROGRESSION CONTROL BY TARGETING OF MULTIPLE ONCOGENIC ACTIVITIES, The Journal of Urology, vol.181, issue.4, pp.1271-1277, 2008.
DOI : 10.1016/S0022-5347(09)60542-5

A. Tong, P. Fulgham, C. Jay, P. Chen, and I. Khalil, MicroRNA profile analysis of human prostate cancers, Cancer Gene Therapy, vol.3, 2008.
DOI : 10.1093/carcin/bgm053

S. Ambs, R. Prueitt, M. Yi, R. Hudson, and T. Howe, Genomic Profiling of MicroRNA and Messenger RNA Reveals Deregulated MicroRNA Expression in Prostate Cancer, Cancer Research, vol.68, issue.15, pp.6162-6170, 2008.
DOI : 10.1158/0008-5472.CAN-08-0144

P. Mitchell, R. Parkin, E. Kroh, B. Fritz, and S. Wyman, Circulating microRNAs as stable blood-based markers for cancer detection, Proceedings of the National Academy of Sciences, vol.105, issue.30, pp.10513-10518, 2008.
DOI : 10.1073/pnas.0804549105
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492472

J. Annicotte, I. Iankova, S. Miard, V. Fritz, and D. Sarruf, Peroxisome Proliferator-Activated Receptor ?? Regulates E-Cadherin Expression and Inhibits Growth and Invasion of Prostate Cancer, Molecular and Cellular Biology, vol.26, issue.20, pp.7561-7574, 2006.
DOI : 10.1128/MCB.00605-06
URL : https://hal.archives-ouvertes.fr/inserm-00096196

A. Abella, P. Dubus, M. Malumbres, S. Rane, and H. Kiyokawa, Cdk4 promotes adipogenesis through PPAR?? activation, Cell Metabolism, vol.2, issue.4, pp.239-249, 2005.
DOI : 10.1016/j.cmet.2005.09.003
URL : http://doi.org/10.1016/j.cmet.2005.09.003

D. Sarruf, I. Iankova, A. Abella, S. Assou, and S. Miard, Cyclin D3 Promotes Adipogenesis through Activation of Peroxisome Proliferator-Activated Receptor ??, Molecular and Cellular Biology, vol.25, issue.22, pp.9985-9995, 2005.
DOI : 10.1128/MCB.25.22.9985-9995.2005
URL : https://hal.archives-ouvertes.fr/inserm-00144667

M. Michael, S. Oc, N. Van-holst-pellekaan, G. Young, and R. James, Reduced accumulation of specific microRNAs in colorectal neoplasia, Mol Cancer Res, vol.1, pp.882-891, 2003.

A. Heidenreich, G. Aus, M. Bolla, S. Joniau, and V. Matveev, EAU Guidelines on Prostate Cancer, European Urology, vol.53, issue.1, pp.68-80, 2008.
DOI : 10.1016/j.eururo.2007.09.002

S. Joniau and H. Van-poppel, Localized prostate cancer: can we better define who is at risk of unfavourable outcome?, BJU International, vol.177, issue.1, pp.5-10, 2008.
DOI : 10.1111/j.1464-410X.2007.07488.x

J. Epstein, W. Allsbrook, . Jr, M. Amin, and L. Egevad, Update on the Gleason Grading System for Prostate Cancer, Advances in Anatomic Pathology, vol.13, issue.1, pp.57-59, 2006.
DOI : 10.1097/01.pap.0000202017.78917.18

S. Sweat, E. Bergstralh, J. Slezak, M. Blute, and H. Zincke, Competing Risk Analysis After Radical Prostatectomy for Clinically Nonmetastatic Prostate Adenocarcinoma According to Clinical Gleason Score and Patient Age, The Journal of Urology, vol.168, issue.2, pp.525-529, 2002.
DOI : 10.1016/S0022-5347(05)64672-1

M. Kattan, T. Wheeler, and P. Scardino, Postoperative Nomogram for Disease Recurrence After Radical Prostatectomy for Prostate Cancer, Journal of Clinical Oncology, vol.17, issue.5, pp.1499-1507, 1999.
DOI : 10.1200/JCO.1999.17.5.1499

Y. Akao, Y. Nakagawa, and T. Naoe, MicroRNA-143 and -145 in Colon Cancer, DNA and Cell Biology, vol.26, issue.5, pp.311-320, 2007.
DOI : 10.1089/dna.2006.0550

Y. Akao, Y. Nakagawa, Y. Kitade, T. Kinoshita, and T. Naoe, Downregulation of microRNAs-143 and -145 in B-cell malignancies, Cancer Science, vol.1, issue.12, pp.1914-1920, 2007.
DOI : 10.1073/pnas.0404432101

K. Porkka, M. Pfeiffer, K. Waltering, R. Vessella, and T. Tammela, MicroRNA Expression Profiling in Prostate Cancer, Cancer Research, vol.67, issue.13, pp.6130-6135, 2007.
DOI : 10.1158/0008-5472.CAN-07-0533

F. Amaral, N. Torres, F. Saggioro, L. Neder, and H. Machado, MicroRNAs Differentially Expressed in ACTH-Secreting Pituitary Tumors, The Journal of Clinical Endocrinology & Metabolism, vol.94, issue.1, pp.320-323, 2009.
DOI : 10.1210/jc.2008-1451

X. Wang, S. Tang, S. Le, R. Lu, and J. Rader, Aberrant Expression of Oncogenic and Tumor-Suppressive MicroRNAs in Cervical Cancer Is Required for Cancer Cell Growth, PLoS ONE, vol.19, issue.7, p.2557, 2008.
DOI : 10.1371/journal.pone.0002557.s002

J. Lu, G. Getz, E. Miska, E. Alvarez-saavedra, and J. Lamb, MicroRNA expression profiles classify human cancers, Nature, vol.1, issue.7043, pp.834-838, 2005.
DOI : 10.1016/S1535-6108(02)00018-1

X. Chen, X. Guo, H. Zhang, Y. Xiang, and J. Chen, Role of miR-143 targeting KRAS in colorectal tumorigenesis, Oncogene, vol.1, issue.10, pp.1385-1392, 2009.
DOI : 10.1038/sj.onc.1210293

C. Esau, X. Kang, E. Peralta, E. Hanson, and E. Marcusson, MicroRNA-143 Regulates Adipocyte Differentiation, Journal of Biological Chemistry, vol.279, issue.50, pp.52361-52365, 2004.
DOI : 10.1074/jbc.C400438200

G. Zhou, Z. Bao, and J. Dixon, Components of a new human protein kinase signal transduction pathway, J Biol Chem, vol.270, pp.12665-12669, 1995.

Y. Kato, V. Kravchenko, R. Tapping, J. Han, and R. Ulevitch, BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C, The EMBO Journal, vol.16, issue.23, pp.7054-7066, 1997.
DOI : 10.1093/emboj/16.23.7054
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170308

J. English, G. Pearson, R. Baer, and M. Cobb, Identification of Substrates and Regulators of the Mitogen-activated Protein Kinase ERK5 Using Chimeric Protein Kinases, Journal of Biological Chemistry, vol.273, issue.7, pp.3854-3860, 1998.
DOI : 10.1074/jbc.273.7.3854

G. Pearson, J. English, M. White, and M. Cobb, ERK5 and ERK2 Cooperate to Regulate NF-??B and Cell Transformation, Journal of Biological Chemistry, vol.276, issue.11, pp.7927-7931, 2001.
DOI : 10.1074/jbc.M009764200

K. Terasawa, K. Okazaki, and E. Nishida, Regulation of c-Fos and Fra-1 by the MEK5-ERK5 pathway, Genes to Cells, vol.270, issue.3, pp.263-273, 2003.
DOI : 10.1128/MCB.22.2.587-598.2002

P. Mehta, B. Jenkins, L. Mccarthy, L. Thilak, and C. Robson, MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion, Oncogene, vol.22, issue.9, pp.1381-1389, 2003.
DOI : 10.1038/sj.onc.1206154