Whole body small animal examination with a diffuse optical tomography instrument

Anne Koenig (1) , Lionel Hervé (1) , Anabela da Silva (1) , Jean-Marc Dinten (1) , Jérôme Boutet (1) , Michel Berger (1) , Isabelle Texier (1) , Philippe Peltié (1) , Philippe Rizo (1) , Veronique Josserand (2) , Jean-Luc Coll (2)

1 CEA-LETI - Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information
2 INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble

We developed a fluorescent diffuse optical tomography instrument in our laboratory to study in vivo tumour growth without any stress or damage for the animal. By taking into account optical heterogeneities, the reconstruction algorithm allows whole body small animal examination. Experimental results obtained with this system on phantoms and on mice deep lung tumours examination are presented in this paper.

Mots clés: Optical tomography; 3D Reconstruction; Fluorescence; In vivo examination

Domaines: Optique [physics.optics]; Biotechnologies; Biotechnologie

Anne Koenig, Lionel Hervé, Anabela da Silva, Jean-Marc Dinten, Jérôme Boutet, et al.. Whole body small animal examination with a diffuse optical tomography instrument. Nuclear Instruments and Methods in Physics Research, 2007, 571, pp.56-59. ⟨inserm-00331928⟩