Occupation and lymphoid malignancies: results from a French case-control study.

Abstract : OBJECTIVES: Investigating relationships between potential occupational risk factors and lymphoid malignancy (LM). METHODS: We conducted a multicenter hospital-based case-control study in France between 2000 and 2004, including 824 incident cases of non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), multiple myeloma, and "lymphoproliferative syndrome" and 752 frequency-matched controls. Data were collected through face-to-face standardized and detailed interviews. RESULTS: Farming was significantly associated with NHL (odds ratio [OR] = 1.4 [1.0 to 2.0]) and, although not significantly, with lymphoproliferative syndrome and multiple myeloma. ORs were higher for longest durations of exposure. Self-declared exposure to pesticides was significantly associated with NHL (OR = 1.8 [1.2 to 2.7]) and HL (OR = 2.2 [1.0 to 4.7]). Neither solvent-related jobs nor self-reported exposure to solvents were related to LM. Systematic screening based on job titles did not evidence any other association. CONCLUSIONS: The results support the hypothesis that farming plays a role in most types of LM.
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Laurent Orsi, Xavier Troussard, Alain Monnereau, Christian Berthou, Pierre Fenaux, et al.. Occupation and lymphoid malignancies: results from a French case-control study.. Journal of Occupational and Environmental Medicine, Lippincott, Williams & Wilkins, 2007, 49 (12), pp.1339-50. ⟨10.1097/JOM.0b013e3181569a49⟩. ⟨inserm-00239464⟩

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