Highly potent and selective ligands for histamine H3-receptors, Nature, vol.327, issue.6118, 1987. ,
DOI : 10.1038/327117a0
Hypocretins (orexins): clinical impact of the discovery of a neurotransmitter, Sleep Medicine Reviews, vol.9, issue.4, pp.253-268, 2005. ,
DOI : 10.1016/j.smrv.2005.01.005
Orexins (hypocretins) directly excite tuberomammillary neurons, European Journal of Neuroscience, vol.901, issue.9, pp.1571-1575, 2001. ,
DOI : 10.1046/j.0953-816x.2001.01777.x
EFNS guidelines on management of narcolepsy, European Journal of Neurology, vol.13, issue.1, pp.1035-1048, 2006. ,
DOI : 10.1002/ana.20339
Sodium oxybate improves excessive daytime sleepiness in narcolepsy, Sleep, vol.29, pp.939-946, 2006. ,
Histamine H3 receptor antagonists: From target identification to drug leads, Biochemical Pharmacology, vol.73, issue.8, pp.1084-1096, 2007. ,
DOI : 10.1016/j.bcp.2006.10.031
Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons, J Neurosci, vol.20, pp.7760-7765, 2000. ,
A detailed mapping of histamine H1-receptors in guinea-pig central nervous system established by autoradiography with [125I]iodobolpyramine. Neurosci, pp.553-600, 1988. ,
Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline), J Neurosci, vol.22, pp.8850-8859, 2002. ,
Narcolepsy in orexin Knockout Mice, Cell, vol.98, issue.4, pp.437-451, 1999. ,
DOI : 10.1016/S0092-8674(00)81973-X
Narcolepsy with cataplexy, The Lancet, vol.369, issue.9560, pp.499-511, 2007. ,
DOI : 10.1016/S0140-6736(07)60237-2
URL : https://hal.archives-ouvertes.fr/hal-00534816
Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus, J Neurosci, vol.21, pp.9273-9279, 2001. ,
The vigilance promoting drug modafinil decreases GABA release in the medial preoptic area and in the posterior hypothalamus of the awake rat: possible involvement of the serotonergic 5-HT3 receptor, Neuroscience Letters, vol.220, issue.1, pp.5-8, 1996. ,
DOI : 10.1016/S0304-3940(96)13212-2
Specificity of direct transition from wake to REM sleep in orexin/ataxin-3 transgenic narcoleptic mice, Experimental Neurology, vol.217, issue.1, p.29, 2006. ,
DOI : 10.1016/j.expneurol.2009.01.015
Arousal effect of orexin A depends on activation of the histaminergic system, Proceedings of the National Academy of Sciences, vol.98, issue.17, pp.9965-9970, 2001. ,
DOI : 10.1073/pnas.181330998
A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale, Sleep, vol.14, issue.6, pp.540-545, 1991. ,
DOI : 10.1093/sleep/14.6.540
Brain neurotransmitter changes in human narcolepsy, Neurology, vol.42, issue.1, pp.229-334, 1992. ,
DOI : 10.1212/WNL.42.1.229
Histamine excites noradrenergic neurons in locus coeruleus in rats, Neuropharmacology, vol.49, issue.1, pp.129-134, 2005. ,
DOI : 10.1016/j.neuropharm.2005.03.001
Brain histamine and schizophrenia: Potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649, Biochemical Pharmacology, vol.73, issue.8, 2007. ,
DOI : 10.1016/j.bcp.2007.01.023
URL : https://hal.archives-ouvertes.fr/inserm-00150117
Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist, J Pharmacol Exp Ther, vol.287, pp.658-666, 1998. ,
BF2.649 [1-??piperidine, Hydrochloride], a Nonimidazole Inverse Agonist/Antagonist at the Human Histamine H3 Receptor: Preclinical Pharmacology, Journal of Pharmacology and Experimental Therapeutics, vol.320, issue.1, pp.365-375, 2007. ,
DOI : 10.1124/jpet.106.111039
URL : https://hal.archives-ouvertes.fr/inserm-00150117
Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat, Brain Research, vol.591, issue.2, pp.319-326, 1992. ,
DOI : 10.1016/0006-8993(92)91713-O
PHYSIOLOGICAL REVIEW ARTICLE: Brain structures and mechanisms involved in the control of cortical activation and wakefulness, with emphasis on the posterior hypothalamus and histaminergic neurons, Sleep Medicine Reviews, vol.4, issue.5, pp.471-503, 2000. ,
DOI : 10.1053/smrv.2000.0116
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene, Cell, vol.98, issue.3, pp.365-376, 1999. ,
DOI : 10.1016/S0092-8674(00)81965-0
Narcolepsy: Pharmacology, Pathophysiology, and Genetics, Principles and Practice of Sleep Medicine, pp.761-779, 2005. ,
DOI : 10.1016/B0-72-160797-7/50071-9
Emerging therapies in narcolepsy-cataplexy, Sleep, vol.28, pp.754-763, 2005. ,
Behavioral State Instability in Orexin Knock-Out Mice, Journal of Neuroscience, vol.24, issue.28, pp.6291-6300, 2004. ,
DOI : 10.1523/JNEUROSCI.0586-04.2004
High constitutive activity of native H3 receptors regulates histamine neurons in brain, Nature, vol.408, pp.860-864, 2000. ,
Decreased brain histamine content in hypocretin/orexin receptor-2 mutated narcoleptic dogs, Neuroscience Letters, vol.313, issue.3, pp.125-128, 2001. ,
DOI : 10.1016/S0304-3940(01)02270-4
Hypocretin (orexin) deficiency in human narcolepsy, The Lancet, vol.355, issue.9197, pp.39-40, 2000. ,
DOI : 10.1016/S0140-6736(99)05582-8
The brain H3-receptor as a novel therapeutic target for vigilance and sleep???wake disorders, Biochemical Pharmacology, vol.73, issue.8, pp.1157-1171, 2007. ,
DOI : 10.1016/j.bcp.2007.01.002
URL : https://hal.archives-ouvertes.fr/inserm-00150083
Anatomical, physiological and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioural and sleep-wake control, J Neurosci, vol.22, pp.7695-7711, 2002. ,
A detailed mapping of the histamine H3 receptor and its gene transcripts in rat brain, Neuroscience, vol.114, issue.1, pp.173-193, 2002. ,
DOI : 10.1016/S0306-4522(02)00135-5
Hypothalamic arousal regions are activated during modafinil-induced wakefulness, J Neurosci, vol.20, pp.8620-8628, 2000. ,
Histamine H3-receptor-mediated inhibition of noradrenaline release in the mouse brain cortex, Naunyn Schmiedebergs Arch Pharmacol, vol.345, pp.489-493, 1992. ,
Histaminergic transmission in the mammalian brain, Physiol Rev, vol.71, pp.1-51, 1991. ,
Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat, J Neurosci, vol.18, pp.4705-4721, 1998. ,
Narcolepsy, Cell, vol.98, issue.4, pp.409-412, 1999. ,
DOI : 10.1016/S0092-8674(00)81969-8
THE HYPOCRETINS: SETTING THE AROUSAL THRESHOLD, Nature Reviews Neuroscience, vol.355, issue.5, pp.339-349, 2002. ,
DOI : 10.1016/S0896-6273(01)00293-8
Neuronal Activity of Histaminergic Tuberomammillary Neurons During Wake-Sleep States in the Mouse, Journal of Neuroscience, vol.26, issue.40, pp.10292-10298, 2006. ,
DOI : 10.1523/JNEUROSCI.2341-06.2006
URL : https://hal.archives-ouvertes.fr/inserm-00408027
Modafinil and cortical ??-aminobutyric acid outflow. Modulation by 5-hydroxytryptamine neurotoxins, European Journal of Pharmacology, vol.273, issue.1-2, pp.63-71, 1995. ,
DOI : 10.1016/0014-2999(94)00675-W
Facteurs g??n??tiques dans le d??terminisme du cycle veille-sommeil chez la souris, Brain Research, vol.69, issue.2, pp.315-330, 1974. ,
DOI : 10.1016/0006-8993(74)90009-2
Enregistrement chronique des activités électriques cérébrales, musculaires et oculaires chez la souris, CR Séances Soc Bio. Fil, vol.165, pp.112-115, 1971. ,
Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophysiological study in freely moving cats, Behavioural Brain Research, vol.144, issue.1-2, pp.227-241, 2003. ,
DOI : 10.1016/S0166-4328(03)00091-3
URL : https://hal.archives-ouvertes.fr/inserm-00408041
Dopaminergic???adrenergic interactions in the wake promoting mechanism of modafinil, Neuroscience, vol.132, issue.4, pp.1027-1034, 2005. ,
DOI : 10.1016/j.neuroscience.2005.02.003
Locus coeruleus neurons: cessation of activity during cataplexy, Neuroscience, vol.91, issue.4, pp.1389-1399, 1999. ,
DOI : 10.1016/S0306-4522(98)00600-9