Fourth order approaches for localization of brain current sources.

Laurent Albera (1) , Anne Ferreol (2) , Delphine Cosandier-Rimele (1) , Isabelle Merlet (1) , Fabrice Wendling (1)

1 LTSI - Laboratoire Traitement du Signal et de l'Image
2 Thales Research and Technology [Palaiseau]

Two high resolution methods solving inverse problems potentially ill-posed, named 4-MUSIC and 4-RapMUSIC, are proposed. They allow for localization of brain current sources with unconstrained orientations from surface electro-or magneto-encephalographic data using spherical or realistic head geometries. The 4-MUSIC and 4-RapMUSIC methods are based on i) the separability of the data transfer matrix as a function of location and orientation parameters and ii) the fourth order (FO) virtual array theory. In addition, 4-RapMUSIC uses the deflation concept extended to FO statistics accounting for the presence of potentially but not totally coherent sources. Computer results display the superiority of the 4-RapMUSIC approach in different situations (two closed sources, additive Gaussian noise with unknown spatial covariance, ...) especially over classical algorithms.

Mots clés: Source localization; Brain activity; Statistical Signal Processing; EEG; Epilepsy; Neurology

Domaines: Ingénierie biomédicale; Traitement du signal et de l'image [eess.SP]; Applications [stat.AP]; Traitement du signal et de l'image [eess.SP]

Laurent Albera, Anne Ferreol, Delphine Cosandier-Rimele, Isabelle Merlet, Fabrice Wendling. Fourth order approaches for localization of brain current sources.. Conference proceedings : .. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2006, 1, pp.4498-501. ⟨10.1109/IEMBS.2006.260063⟩. ⟨inserm-00183642⟩