Global distribution of Panton-Valentine leukocidin--positive methicillin-resistant Staphylococcus aureus, 2006.

Anne Tristan (1) , Michèle Bes (1) , Hélène Meugnier (1) , Gérard Lina (1) , Bülent Bozdogan (2) , Patrice Courvalin (2) , Marie-Elisabeth Reverdy (1) , Mark C. Enright (3) , François Vandenesch (1) , Jérôme Etienne (1)

1 Pathogenie des Staphylocoques
2 Agents antibactériens
3 DIDE - Department of Infectious Disease Epidemiology [London]

We determined the agr type, multilocus sequence type, protein A gene type (spa typing), toxin gene profile, and antimicrobial drug resistance profile of 469 isolates of Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus isolates (PVL-positive CA-MRSA). The isolates had been collected from around the world from 1999 through 2005 by the French National Reference Center for Staphylococci. We found that some continent-specific clones described in 2003, such as clone ST8, have now spread all over the world. Likewise, some PVL-positive CA-MRSA have spread to several countries on various continents. New clones have emerged (e.g., ST377) on new genetic backgrounds. PVL-positive CA-MRSA that were usually susceptible to most antistaphylococcal antimicrobial agents have acquired new resistance determinants (e.g., to gentamicin) in certain countries. The major trait shared by all these clones is a short staphylococcal chromosomal cassette mec element of type IV or V.

Mots clés: community-acquired methicillin-resistant Staphylococcus aureus; spa typing; toxin; antibiotic resistance; Panton-Valentine leukocidin; staphylococcal chromosomal cassette mec element; multilocus sequence type

Domaines: Microbiologie et Parasitologie

Anne Tristan, Michèle Bes, Hélène Meugnier, Gérard Lina, Bülent Bozdogan, et al.. Global distribution of Panton-Valentine leukocidin--positive methicillin-resistant Staphylococcus aureus, 2006.. Emerging Infectious Diseases, 2007, 13 (4), pp.594-600. ⟨10.3201/eid1304.061316⟩. ⟨inserm-00157272⟩