D. Bar-sagi and A. Hall, Ras and Rho GTPases, Cell, vol.103, issue.2, pp.227-238, 2000.
DOI : 10.1016/S0092-8674(00)00115-X

M. C. Chenard, P. Rio, and . Chambon, A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas, Nature, vol.348, pp.699-704, 1990.

. Liaudet-coopman, Cathepsin-D affects multiple steps of tumor progression: Proliferation, angiogenesis and apoptosis, Oncogene, vol.21, pp.5951-5955, 2002.

. Senik, Cathepsin D triggers Bax activation, resulting in selective apoptosisinducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis, J. Biol. Chem, vol.278, pp.31401-31411, 2003.

J. M. Rosenbaum, P. Foidart, A. Birembaut, and . Noel, Restricted expression of membrane type 1-matrix metalloproteinase by myofibroblasts adjacent to human breast cancer cells, Int. J. Cancer, vol.105, pp.7-13, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-00149037

P. Briozzo, M. Morisset, F. Capony, C. Rougeot, and H. Rochefort, In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells, Cancer Res, vol.48, pp.3688-3692, 1988.

M. J. Clague, Molecular aspects of the endocytic pathway, Biochemical Journal, vol.336, issue.2, pp.271-282, 1998.
DOI : 10.1042/bj3360271

P. M. Comoglio, L. Tamagnone, and C. Boccaccio, Plasminogen-Related Growth Factor and Semaphorin Receptors: A Gene Superfamily Controlling Invasive Growth, Experimental Cell Research, vol.253, issue.1, pp.88-99, 1999.
DOI : 10.1006/excr.1999.4684

B. Elenbaas and R. A. Weinberg, Heterotypic Signaling between Epithelial Tumor Cells and Fibroblasts in Carcinoma Formation, Experimental Cell Research, vol.264, issue.1, pp.169-84, 2001.
DOI : 10.1006/excr.2000.5133

J. G. Putten and . Klijn, Cathepsin-D in primary breast cancer: prognostic evaluation involving 2810 patients, Br. J. Cancer, vol.79, pp.300-307, 1999.

M. Garcia, D. Derocq, P. Pujol, and H. Rochefort, Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency, Oncogene, vol.5, pp.1809-1814, 1990.

. Coopman, A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells, Oncogene, vol.20, pp.6920-6929, 2001.

F. Grinnell, Fibroblasts, myofibroblasts, and wound contraction, The Journal of Cell Biology, vol.124, issue.4, pp.401-404, 1994.
DOI : 10.1083/jcb.124.4.401
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119916

A. Iwabu, K. Smith, F. D. Allen, D. A. Lauffenburger, and A. Wells, EGF induces fibroblast contractility and motility via a PKCdelta -dependent pathway, J. Biol. Chem, 2004.

H. Kataoka, H. Tanaka, K. Nagaike, S. Uchiyama, and H. Itoh, Role of Cancer Cell-Stroma Interaction in Invasive Growth of Cancer Cells, Human Cell, vol.277, issue.1, pp.1-14, 2003.
DOI : 10.1111/j.1749-0774.2003.tb00123.x

J. E. Koblinski, J. Dosescu, M. Sameni, K. Moin, K. Clark et al., Interaction of Human Breast Fibroblasts with Collagen I Increases Secretion of Procathepsin B, Journal of Biological Chemistry, vol.277, issue.35, pp.32220-32227, 2002.
DOI : 10.1074/jbc.M204708200

M. Koike, M. Shibata, Y. Ohsawa, H. Nakanishi, T. Koga et al., lysosomal targeting signal and active site, EMBO J, vol.12, pp.1293-1302, 2003.

C. Figura, K. Peters, P. Yamamoto, Y. Saftig, and . Uchiyama, Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice, J. Neurosci, vol.21, pp.7526-7533, 2001.

K. Nakashiro, M. Okamoto, Y. Hayashi, and R. Oyasu, Hepatocyte Growth Factor Secreted by Prostate-Derived Stromal Cells Stimulates Growth of Androgen-Independent Human Prostatic Carcinoma Cells, The American Journal of Pathology, vol.157, issue.3, pp.795-803, 2000.
DOI : 10.1016/S0002-9440(10)64593-2

H. Nakayasu and R. Rerezney, Mapping replicational sites in the eucaryotic cell nucleus, The Journal of Cell Biology, vol.108, issue.1, pp.1-11, 1989.
DOI : 10.1083/jcb.108.1.1

S. M. Pupa, S. Ménard, S. Forti, and E. Tagliabue, New insights into the role of extracellular matrix during tumor onset and progression, Journal of Cellular Physiology, vol.4, issue.3, pp.259-267, 2002.
DOI : 10.1002/jcp.10142

H. Rochefort, Cathepsin D in breast cancer: A tissue marker associated with metastasis, European Journal of Cancer, vol.28, issue.11, pp.1780-1783, 1992.
DOI : 10.1016/0959-8049(92)90003-K

H. Rochefort and E. Liaudet-coopman, Cathepsin D in cancer metastasis: A protease and a ligand, APMIS, vol.57, issue.1-6, pp.86-95, 1999.
DOI : 10.1111/j.1699-0463.1999.tb01530.x

F. Morisset and . Vignon, Estrogen-induced lysosomal proteases secreted by breast cancer cells: a role in carcinogenesis?, J. Cell. Biochem, vol.35, pp.17-29, 1987.

M. Hess, K. V. Evers, C. Figura, and . Peters, Mice deficient for the lysosomal proteinase cathepsin D exibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells, EMBO J, vol.14, pp.3599-3608, 1995.

J. Schlessinger, Cell Signaling by Receptor Tyrosine Kinases, Cell, vol.103, issue.2, 2000.
DOI : 10.1016/S0092-8674(00)00114-8

M. P. Shekhar, J. Werdell, S. J. Santner, R. J. Pauley, and L. Tait, Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression, Cancer Res, vol.61, pp.1320-1326, 2001.

A. M. Sieuwerts, J. G. Klijn, S. C. Henzen-logmans, and J. A. Foekens, Cytokine???regulated urokinase???type???plasminogen???activator (uPA) production by human breast fibroblasts in vitro, Breast Cancer Research and Treatment, vol.88, issue.1, pp.9-20, 1999.
DOI : 10.1023/A:1006190729866