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Journal articles
Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study.
Sheila Bingham
1
Nicholas Day
2
Robert Luben
2
Pietro Ferrari
3
Nadia Slimani
3
Teresa Norat
3
Françoise Clavel-Chapelon
4, 5
Emmanuelle Kesse
5
Alexandra Nieters
6
Heiner Boeing
7
Anne Tjønneland
8
Kim Overvad
9, 10
Carmen Martinez
11
Miren Dorronsoro
12
Carlos Gonzalez
13
Timothy Key
14
Antonia Trichopoulou
15
Androniki Naska
15
Paolo Vineis
16
Rosario Tumino
17
Vittorio Krogh
18
H Bas Bueno-De-Mesquita
19
Petra Peeters
20
Göran Berglund
21
Göran Hallmans
22
Eiliv Lund
23
Guri Skeie
23
Rudolf Kaaks
3
Elio Riboli
3
Nadia Slimani 3
Author
Teresa Norat 3
Author
Françoise Clavel-Chapelon 4, 5
Author
Emmanuelle Kesse 5
Author
Carmen Martinez 11
Author
Miren Dorronsoro 12
Author
Carlos A. Gonzalez 13
Author
Timothy J. Key 14
Author
Antonia Trichopoulou 15
Author
Androniki Naska 15
Author
Paolo Vineis 16
Author
Rosario Tumino 17
Author
Vittorio Krogh 18
Author
H Bas Bueno-De-Mesquita 19
Author
Petra H. M. Peeters 20
Author
Göran Berglund 21
Author
Elio Riboli 3
Author
2
Strangeways Research Laboratory (Cambridge - United Kingdom)
- CAM - University of Cambridge [UK] (The Old Schools, Trinity Lane, Cambridge CB2 1TN - United Kingdom)
3
Unit of Nutrition and Cancer (150, cours Albert Thomas 69372 Lyon cedex 08 - France)
- IACR - International Agency for Cancer Research (150 Cours Albert Thomas, 69372 Lyon CEDEX 08 - France)
4
E3N - Nutrition, hormones et cancer: épidémiologie et prévention (Institut Gustave-Roussy 39 rue Camille Desmoulins 94805 Villejuif CEDEX - France)
- IFR 69 - Epidémiologie, sciences sociales, santé publique (Centre de Recherche Inserm 16, Avenue Paul Vaillant-Couturier 94807 VILLEJUIF CEDEX - France)
- UP1 - Université Paris 1 Panthéon-Sorbonne (12 place du Panthéon - 75231 Paris Cedex 05 - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- EHESS - École des hautes études en sciences sociales (54, boulevard Raspail 75006 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- UPD5 - Université Paris Descartes - Paris 5 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : IFR69 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : IFR69 (France)
- UP11 - Université Paris-Sud - Paris 11 : EA4045 (Bâtiment 300 - 91405 Orsay cedex - France)
- IGR - Institut Gustave Roussy (114, rue Édouard-Vaillant 94805 Villejuif Cedex -France - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : ERI20 (101, rue de Tolbiac, 75013 Paris - France)
5
Epidémiologie des cancers (Institut Gustave Roussy Villejuif - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U521 (101, rue de Tolbiac, 75013 Paris - France)
6
DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (German Cancer Research Center Im Neuenheimer Feld 280 D-69120 Heidelberg - Germany)
7
DifE - Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (Arthur-Scheunert-Allee 114-116, 14558 Nuthetal
- Germany)
- Leibniz Association (Chausseestraße 111, 10115 Berlin - Germany)
9
Department of Clinical Epidemiology (Aarhus - Denmark)
- Aarhus University Hospital (Aarhus University Hospital Norrebrogade 44 DK-8000 Aarhus C - Denmark)
10
Department of Cardiology and Department of Clinical Epidemiology (Aalborg - Denmark)
- Aarhus University Hospital (Aarhus University Hospital Norrebrogade 44 DK-8000 Aarhus C - Denmark)
11
Andalusian School of Public Health [Granada] (Granada, Spain - Spain)
12
Department of Public Health of Guipuzkoa (San Sebastian - Spain)
15
University of Athens Medical School [Athens] (Athens 115 27 - Greece)
16
University of Torino and CPO-Piemonte (Torino - Italy)
- UNITO - Università degli studi di Torino (Via Verdi, 8 10124 Torino Italie - Italy)
18
Department of Epidemiology (Milan - Italy)
- NCI-NIH - National Cancer Institute [Bethesda] (BG 9609 MSC 9760, 9609 Medical Center Drive, Bethesda, MD 20892-9760 - United States)
- NIH - National Institutes of Health [Bethesda] (9000 Rockville Pike, Bethesda, Maryland 20892 - United States)
19
RIVM - National Institute for Public Health and the Environment [Bilthoven] (Antonie van Leeuwenhoeklaan 9, 3721 MA, Bilthoven / PO Box 1, 3720 BA Bilthoven - Netherlands)
20
Julius Centre for Health Sciences and Primary Care (Netherlands)
- VU University Medical Center [Amsterdam] (De Boelelaan 1118, 1081 HZ Amsterdam - Netherlands)
21
Malmö Diet and Cancer Study (Malmö - Sweden)
- Lund University [Lund] (Paradisgatan 2 Box 117, SE-221 00 Lund - Sweden)
22
Department of Nutritional Research (Umea - Sweden)
- Umeå University (SE-901 87 Umeå, Sweden - Sweden)
23
Institute of Community Medicine (Tromso - Norway)
- UiT - University of Tromsø (The Arctic University of Norway, PO Box 6050, Langnes 9037 Tromsø - Norway)
Abstract : BACKGROUND: Dietary fibre is thought to protect against colorectal cancer but this view has been challenged by recent prospective and intervention studies that showed no protective effect. METHODS: We prospectively examined the association between dietary fibre intake and incidence of colorectal cancer in 519978 individuals aged 25-70 years taking part in the EPIC study, recruited from ten European countries. Participants completed a dietary questionnaire in 1992-98 and were followed up for cancer incidence. Relative risk estimates were obtained from fibre intake, categorised by sex-specific, cohort-wide quintiles, and from linear models relating the hazard ratio to fibre intake expressed as a continuous variable. FINDINGS: Follow-up consisted of 1939011 person-years, and data for 1065 reported cases of colorectal cancer were included in the analysis. Dietary fibre in foods was inversely related to incidence of large bowel cancer (adjusted relative risk 0.75 [95% CI 0.59-0.95] for the highest versus lowest quintile of intake), the protective effect being greatest for the left side of the colon, and least for the rectum. After calibration with more detailed dietary data, the adjusted relative risk for the highest versus lowest quintile of fibre from food intake was 0.58 (0.41-0.85). No food source of fibre was significantly more protective than others, and non-food supplement sources of fibre were not investigated. INTERPRETATION: In populations with low average intake of dietary fibre, an approximate doubling of total fibre intake from foods could reduce the risk of colorectal cancer by 40%.
Document type :
Journal articles
Complete list of metadatas
https://www.hal.inserm.fr/inserm-00110132
Contributor : F. Clavel-Chapelon <>
Submitted on : Thursday, November 9, 2006 - 3:18:04 PM
Last modification on : Tuesday, January 19, 2021 - 11:08:31 AM
Long-term archiving on: : Friday, November 25, 2016 - 1:41:15 PM
Contributor : F. Clavel-Chapelon <>
Submitted on : Thursday, November 9, 2006 - 3:18:04 PM
Last modification on : Tuesday, January 19, 2021 - 11:08:31 AM
Long-term archiving on: : Friday, November 25, 2016 - 1:41:15 PM
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Identifiers
- HAL Id : inserm-00110132, version 1
- PUBMED : 12737858
Collections
IFR69 | IGR | FNCLCC | CNRS | EHESS | UNIV-PARIS1 | UNIV-PARIS5 | USPC | UNIV-PARIS | POLITIQUES-PUBLIQUES
Citation
Sheila Bingham, Nicholas Day, Robert Luben, Pietro Ferrari, Nadia Slimani, et al.. Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study.. The Lancet, Elsevier, 2003, 361 (9368), pp.1496-501. ⟨inserm-00110132⟩
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