Skip to Main content Skip to Navigation
Journal articles

Bidirectional control of quantal size by synaptic activity in the hippocampus.

Abstract : Analysis of strontium-induced asynchronous release of quanta from stimulated synapses revealed that long-term potentiation and long-term depression in the CA1 region of the mammalian hippocampus are associated with an increase and a decrease, respectively, in quantal size. At a single set of synapses, the increase in quantal size seen with long-term potentiation was completely reversed by depotentiating stimuli. Long-term potentiation and depression are also associated with an increase and decrease, respectively, in the frequency of quantal events, consistent with an all-or-none regulation (up or down) of clusters of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, a change in the release of transmitter, or both.
Document type :
Journal articles
Complete list of metadata
Contributor : Stéphane Oliet Connect in order to contact the contributor
Submitted on : Wednesday, March 29, 2006 - 12:17:52 PM
Last modification on : Monday, May 9, 2022 - 11:58:07 AM


  • HAL Id : inserm-00000076, version 1
  • PUBMED : 8638114



Stéphane H.R. Oliet, Robert C. Malenka, Roger A. Nicoll. Bidirectional control of quantal size by synaptic activity in the hippocampus.. Science, American Association for the Advancement of Science (AAAS), 1996, 271, pp.1294-7. ⟨inserm-00000076⟩



Record views