Abstract : In some real world situations, linear models are not sufficient to represent accurately complex relations between input variables and output variables of a studied system. Multilayer Perceptrons are one of the most successful non-linear regression tool but they are unfortunately restricted to inputs and outputs that belong to a normed vector space. In this chapter, we propose a general recoding method that allows to use symbolic data both as inputs and outputs to Multilayer Perceptrons. The recoding is quite simple to implement and yet provides a flexible framework that allows to deal with almost all practical cases. The proposed method is illustrated on a real world data set.