Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI
Résumé
previous termIn childrennext term with attention deficit hyperactivity disorder (ADHD), functional neuroimaging studies have revealed abnormalities previous terminnext term various previous termbrainnext term regions, including prefrontal-striatal circuit, cerebellum, and brainstem. previous termInnext term the current study, we used a new marker of functional magnetic resonance imaging (fMRI), amplitude of low-frequency (0.01–0.08 Hz) fluctuation (ALFF) to investigate the previous termbaseline brainnext term function of this disorder. Thirteen boys with ADHD (13.0 ± 1.4 years) were examined by resting-state fMRI and compared with age-matched controls. As a result, we found that patients with ADHD had decreased ALFF previous terminnext term the right inferior frontal cortex, left sensorimotor cortex, and bilateral cerebellum and the vermis as well as increased ALFF previous terminnext term the right anterior cingulated cortex, left sensorimotor cortex, and bilateral brainstem. This resting-state fMRI study suggests that the changed spontaneous neuronal previous termactivitynext term of these regions may be implicated previous terminnext term the underlying pathophysiology previous termin childrennext term with ADHD.