Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate

France Denoeud 1 Simon Henriet 2 Sutada Mungpakdee 2 Jean-Marc Aury 3 Corinne da Silva 3 Henner Brinkmann 4 Jana Mikhaleva 2 Lisbeth Charlotte Olsen 2 Claire Jubin 5 Cristian Cañestro 6 Jean-Marie Bouquet 2 Gemma Danks 2 Julie Poulain 5 Coen Campsteijn 2 Marcin Adamski 2 Ismael Cross 7 Fekadu Yadetie 2 Matthieu Muffato 8 Alexandra Louis 8 Stephen Butcher 9 Georgia Tsagkogeorga 10 Anke Konrad 11 Sarabdeep Singh 12 Marit Flo Jensen 2 Evelyne Huynh Cong 2 Helen Eikeseth-Otteraa 2 Benjamin Noel 3, 13 Véronique Anthouard 14 Betina M Porcel 3 Rym Kachouri-Lafond 15 Atsuo Nishino 16 Matteo Ugolini 2 Pascal Chourrout 17 Hiroki Nishida 16 Rein Aasland 18 Snehalata Huzurbazar 12 Eric Westhof 15 Frédéric Delsuc 10 Hans Lehrach 19 Richard Reinhardt 20 Jean Weissenbach 3 Scott W Roy 21 François Artiguenave 3 John H Postlethwait 22 J Robert Manak 9 Eric Thompson 2 Olivier Jaillon 3 Louis Du Pasquier 23 Pierre Boudinot 24 David Liberles 11 Jean-Nicolas Volff 25 Hervé Philippe 4 Boris Lenhard 2 Hugues Roest Crollius 8 Patrick Wincker 14 Daniel Chourrout 2
Abstract : Genomes of animals as different as sponges and humans show conservation of global architecture. Here we show that multiple genomic features including transposon diversity, developmental gene repertoire, physical gene order, and intron-exon organization are shattered in the tunicate Oikopleura, belonging to the sister group of vertebrates and retaining chordate morphology. Ancestral architecture of animal genomes can be deeply modified and may therefore be largely nonadaptive. This rapidly evolving animal lineage thus offers unique perspectives on the level of genome plasticity. It also illuminates issues as fundamental as the mechanisms of intron gain.
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France Denoeud, Simon Henriet, Sutada Mungpakdee, Jean-Marc Aury, Corinne da Silva, et al.. Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate. Science, American Association for the Advancement of Science, 2010, 330 (6009), pp.1381-1385. ⟨10.1126/science.1194167⟩. ⟨halsde-00544648⟩

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