In silico experiments of intimal hyperplasia development: disendothelization in an axisymmetric idealized artery

Jérôme Jansen (1) , Xavier Escriva (1) , Fabien Godeferd (1) , Patrick Feugier (1)

1 LMFA - Laboratoire de Mecanique des Fluides et d'Acoustique

We use in silico experiments to study the role of the hemodynamics and of the type of disendothelization on the physiopathology of intimal hyperplasia. We apply a multiscale bio-chemo-mechanical model of intimal hyperplasia on an idealized axisymmetric artery that suffers two kinds of disendothelizations. The model predicts the spatio-temporal evolution of the lesions development, initially localized at the site of damages, and after few days displaced downstream of the damaged zones, these two stages being observed whatever the kind of damage. Considering macroscopic quantities, the model sensitivity to pathology-protective and pathology-promoting zones is qualitatively consistent with experimental findings. The simulated pathological evolutions demonstrate the central role of two parameters: (a) the initial damage shape on the morphology of the incipient stenosis, and (b) the local wall shear stresses on the overall spatio-temporal dynamics of the lesion.

Mots clés: Intimal hyperplasia Growth and Remodelling Hemodynamics Wall Shear Stress Multiscale modeling Contents; Intimal hyperplasia; Growth and Remodelling; Hemodynamics; Wall Shear Stress; Multiscale modeling Contents

Domaines: Mécanique [physics.med-ph]; Ingénierie biomédicale

Jérôme Jansen, Xavier Escriva, Fabien Godeferd, Patrick Feugier. In silico experiments of intimal hyperplasia development: disendothelization in an axisymmetric idealized artery. Biomechanics and Modeling in Mechanobiology, 2023, ⟨10.1007/s10237-023-01720-7⟩. ⟨hal-04085178v2⟩