Estimating the risk of incident SARS-CoV-2 infection among healthcare workers in quarantine hospitals: the Egyptian example

Sofía Jijón (1, 2, 3) , Ahmad Al Shafie (4) , Essam Ali Hassan (5) , Laura Temime (1, 2) , Kévin Jean (1, 2, 6) , Mohamed El-Kassas (4)

1 MESuRS - Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires
2 PACRI - Pasteur-Cnam Risques infectieux et émergents
3 iEES Paris - Institut d'écologie et des sciences de l'environnement de Paris
4 Helwan University [Caire]
5 Fayoum University
6 Imperial College London

In response to the COVID-19 epidemic, Egypt established a unique care model based on quarantine hospitals where only externally-referred confirmed COVID-19 patients were admitted, and healthcare workers resided continuously over 1- to 2-week working shifts. Using a mathematical model accounting for the false-negative rates of RT-PCR tests, we computed the incidence rate of SARS-CoV-2 infection among HCWs, while unveiling the proportion of infections remaining undiagnosed despite routine testing. We relied on longitudinal data, including results of routine RT-PCR tests, collected within three Egyptian quarantine hospitals. We estimated an incidence rate (per 100 person-day, PD) of 1.05 (95% CrI 0.58–1.65) at Hospital 1, 1.92 (95% CrI 0.93–3.28) at Hospital 2 and 7.62 (95% CrI 3.47–13.70) at Hospital 3. We found that the risk for an HCW to be infected during a working shift lay within the range of risk levels previously documented in standard healthcare settings for Hospitals 1–2, whereas it was > threefold higher for Hospital 3. This large variation suggests that HCWs from quarantine hospitals may face a high occupational risk of infection, but that, with sufficient infection control measures, this risk can be brought down to levels similar to those observed in standard healthcare settings.

Domaines: Sciences du Vivant [q-bio]

Sofía Jijón, Ahmad Al Shafie, Essam Ali Hassan, Laura Temime, Kévin Jean, et al.. Estimating the risk of incident SARS-CoV-2 infection among healthcare workers in quarantine hospitals: the Egyptian example. Scientific Reports, 2022, 12 (1), ⟨10.1038/s41598-022-23428-x⟩. ⟨hal-03888873v2⟩