Bisphosphonylallenes as Suitable Scaffolds for Unprecedented 4,5-Diphosphonyldihydropyridazines and 3,4-Diphosphonylpyrroles Displaying Antimelanoma Activity

Kmar Abaid (1, 2) , William Erb (2) , David Virieux (3) , Laurent Picot (4) , Benjamin Musnier (4) , Valérie Thiéry (4) , Thierry Roisnel (2) , Florence Mongin (2) , Soufiane Touil (1)

1 UCAR - Université de Carthage (Tunisie)
2 ISCR - Institut des Sciences Chimiques de Rennes
3 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
4 LIENSs - LIttoral ENvironnement et Sociétés

An efficient and simple approach has been developed for the synthesis of unprecedented 4,5-diphosphonyldihydropyridazines and 3,4-diphosphonylpyrroles, through the condensation of bisphosphonylallenes with hydrazines and primary amines, respectively. The reactions proceed under operationally simple, mild, and catalyst-free conditions, for a wide substrate scope. The synthesized compounds were screened for their antiproliferative activity against melanoma cancer cells, and they showed promising growth inhibition.

Domaines: Chimie

Kmar Abaid, William Erb, David Virieux, Laurent Picot, Benjamin Musnier, et al.. Bisphosphonylallenes as Suitable Scaffolds for Unprecedented 4,5-Diphosphonyldihydropyridazines and 3,4-Diphosphonylpyrroles Displaying Antimelanoma Activity. ACS Omega, 2022, 7 (43), pp.38894-38901. ⟨10.1021/acsomega.2c04619⟩. ⟨hal-03884897⟩