Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores

Lora L Martucci (1) , José-Manuel Cancela (1)

1 NeuroPSI - Institut des Neurosciences Paris-Saclay

Ca 2+ signalling is of prime importance in controlling numerous cell functions in the brain. Endolysosomes are acidic organelles currently emerging as important Ca 2+ stores in astrocytes, microglia, endothelial cells, and neurons. In neurons, these acidic Ca 2+ stores are found in axons, soma, dendrites, and axon endings and could provide local sources of Ca 2+ to control synaptic transmission, neuronal plasticity, and autophagy to name a few. This review will address how acidic Ca 2+ stores are recruited in response to cell stimulation. We will focus on the role of the endolysosomal two-pore channels (TPCs) and their physiological agonist nicotinic acid adenine dinucleotide phosphate (NAADP) and how they interact with cyclic ADP-ribose and ryanodine receptors from the endoplasmic reticulum. Finally, this review will describe new pharmacological tools and animal mutant models now available to explore acidic Ca 2+ stores as key elements in brain function and dysfunction.

Domaines: Neurobiologie

Lora L Martucci, José-Manuel Cancela. Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores. Cell Calcium, 2022, 104, pp.102582. ⟨10.1016/j.ceca.2022.102582⟩. ⟨hal-03875116⟩