In pursuit of the epileptogenic zone in focal epilepsy:a dynamical network biomarker approach

Claudio Runfola (1) , Hiba Sheheitli (1) , Fabrice Bartolomei (1, 2) , Huifang Wang (1) , Viktor Jirsa (1)

1 INS - Institut de Neurosciences des Systèmes
2 APHM - Assistance Publique - Hôpitaux de Marseille

The success of resection surgery for drug-resistant epilepsy patients hinges on the correct identification of the epileptogenic zone (EZ) consisting of the subnetwork of brain regions that underlies seizure genesis in focal epilepsy. The dynamical network biomarker (DNB) method is a dynamical systems-based network analysis approach for identifying subnetworks that are the first to exhibit the transition as a complex system undergoes a bifurcation. The approach was devised and validated in the context of complex disease onset where the dynamics is known to be nonlinear and high-dimensional. We here adapt and implement the DNB approach for the identification of the EZ from the analysis of Stereoelectroencephalography (SEEG) data. The method is first successfully tested on simulated data generated with a large-scale brain network model of epilepsy using The Virtual Brain neuroinformatic platform and then applied to clinical SEEG data from focal epilepsy patients. The results are compared with those obtained by expert clinicians that designate the EZ using the Epileptogenicity Index (EI) method. High average precision values are obtained and posit the presented approach as a promising candidate tool for the pursuit of EZ in focal epilepsy.

Mots clés: Dynamical network biomarker; Epileptogenic zone; Seizure onset; Focal epilepsy; Center manifold theory; Bifurcation

Domaines: Neurosciences; Neurosciences [q-bio.NC]

Claudio Runfola, Hiba Sheheitli, Fabrice Bartolomei, Huifang Wang, Viktor Jirsa. In pursuit of the epileptogenic zone in focal epilepsy:a dynamical network biomarker approach. Communications in Nonlinear Science and Numerical Simulation, 2023, 117, pp.106973. ⟨10.1016/j.cnsns.2022.106973⟩. ⟨hal-03851775⟩