Whole-brain propagation delays in multiple sclerosis, a combined tractography - magnetoencephalography study

Pierpaolo Sorrentino (1) , Spase Petkoski (1) , Maddalena Sparaco , Emahnuel Troisi Lopez , Elisabetta Signoriello , Fabio Baselice , Simona Bonavita , Maria Agnese Pirozzi , Mario Quarantelli , Giuseppe Sorrentino , Viktor Jirsa (1)

1 INS - Institut de Neurosciences des Systèmes

Two structurally connected brain regions are more likely to interact, with the lengths of the structural bundles, their widths, myelination, and the topology of the structural connectome influencing the timing of the interactions. We introduce an in vivo approach for measuring functional delays across the whole brain in humans (of either sex) using magneto/electroencephalography (MEG/EEG) and integrating them with the structural bundles. The resulting topochronic map of the functional delays/velocities shows that larger bundles have faster velocities. We estimated the topochronic map in multiple sclerosis patients, who have damaged myelin sheaths, and controls, demonstrating greater delays in patients across the network and that structurally lesioned tracts were slowed down more than unaffected ones. We provide a novel framework for estimating functional transmission delays in vivo at the single-subject and single-tract level.

Mots clés: brain criticality; brain dynamics; brain networks; conduction velocities; magnetoencephalography; multiple sclerosis

Domaines: Neurosciences; Neurosciences [q-bio.NC]

Pierpaolo Sorrentino, Spase Petkoski, Maddalena Sparaco, Emahnuel Troisi Lopez, Elisabetta Signoriello, et al.. Whole-brain propagation delays in multiple sclerosis, a combined tractography - magnetoencephalography study. Journal of Neuroscience, 2022, pp.JN-RM-0938-22. ⟨10.1523/jneurosci.0938-22.2022⟩. ⟨hal-03851744⟩