Exposure to 1800 MHz LTE electromagnetic fields under proinflammatory conditions decreases the response strength and increases the acoustic threshold of auditory cortical neurons

Samira Souffi (1) , Julie Lameth (2) , Quentin Gaucher (1) , Délia Arnaud-Cormos (3) , Philippe Lévêque (3) , Jean-Marc Edeline (1) , Michel Mallat (2)

1 NeuroPSI - Institut des Neurosciences Paris-Saclay
2 ICM - Institut du Cerveau = Paris Brain Institute
3 XLIM - XLIM

Increased needs for mobile phone communications have raised successive generations (G) of wireless technologies, which could differentially affect biological systems. To test this, we exposed rats to single head-only exposure of a 4G long-term evolution (LTE)-1800 MHz electromagnetic field (EMF) for 2 h. We then assessed the impact on microglial space coverage and electrophysiological neuronal activity in the primary auditory cortex (ACx), under acute neuroinflammation induced by lipopolysaccharide. The mean specific absorption rate in the ACx was 0.5 W/kg. Multiunit recording revealed that LTE-EMF triggered reduction in the response strength to pure tones and to natural vocalizations, together with an increase in acoustic threshold in the low and medium frequencies. Iba1 immunohistochemistry showed no change in the area covered by microglia cell bodies and processes. In healthy rats, the same LTE-exposure induced no change in response strength and acoustic threshold. Our data indicate that acute neuroinflammation sensitizes neuronal responses to LTE-EMF, which leads to an altered processing of acoustic stimuli in the ACx.

Domaines: Neurosciences [q-bio.NC]

Samira Souffi, Julie Lameth, Quentin Gaucher, Délia Arnaud-Cormos, Philippe Lévêque, et al.. Exposure to 1800 MHz LTE electromagnetic fields under proinflammatory conditions decreases the response strength and increases the acoustic threshold of auditory cortical neurons. Scientific Reports, 2022, 12 (1), pp.4063. ⟨10.1038/s41598-022-07923-9⟩. ⟨hal-03601893⟩