Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism

Fabrice Lejeune (1, 2)

1 CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277
2 Institut Pasteur de Lille

Nonsense-mediated mRNA decay (NMD) is both a mechanism for rapidly eliminating mRNAs carrying a premature termination codon and a pathway that regulates many genes. This implies that NMD must be subject to regulation in order to allow, under certain physiological conditions, the expression of genes that are normally repressed by NMD. Therapeutically, it might be interesting to express certain NMD-repressed genes or to allow the synthesis of functional truncated proteins. Developing such approaches will require a good understanding of NMD regulation. This review describes the different levels of this regulation in human cells.

Mots clés: Nonsense-Mediated mRNA Decay; UPF proteins; regulation; gene expression; therapeutic perspectives

Domaines: Génomique, Transcriptomique et Protéomique [q-bio.GN]

Fabrice Lejeune. Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism. Biomedicines, 2022, 10 (1), pp.141. ⟨10.3390/biomedicines10010141⟩. ⟨hal-03818960⟩